Abstract:
:Inflammation is an important vertebrate defense mechanism against ecto-parasites for which ticks have evolved numerous mechanisms of modulation. AM-33 and TSGP4, related lipocalins from the soft ticks Argas monolakensis and Ornithodoros savignyi bind cysteinyl leukotrienes with high affinity as measured by isothermal titration calorimetry. This was confirmed in a smooth muscle bioassay that measured contraction of guinea pig ileum induced by leukotriene C4 where both proteins inhibited contraction effectively. Conservation of this function in two diverse soft tick genera suggests that scavenging of cysteinyl leukotrienes evolved in the ancestral soft tick lineage. In addition soft ticks also evolved mechanisms that target other mediators of inflammation that include scavenging of histamine, serotonin, leukotriene B4, thromboxane A2, ATP and inhibition of the complement cascade. Inhibitors of blood-coagulation and platelet aggregation were also present in the ancestral soft tick lineage. Because histamine and cysteinyl leukotrienes are mainly produced by mast cells and basophils, and these cells are important in the mediation of tick rejection reactions, these findings indicate an ancient antagonistic relationship between ticks and the immune system. As such, modulation of the hemostatic system as well as inflammation was important adaptive responses in the evolution of a blood-feeding lifestyle in soft ticks.
journal_name
Insect Biochem Mol Bioljournal_title
Insect biochemistry and molecular biologyauthors
Mans BJ,Ribeiro JMdoi
10.1016/j.ibmb.2008.06.002subject
Has Abstractpub_date
2008-09-01 00:00:00pages
862-70issue
9eissn
0965-1748issn
1879-0240pii
S0965-1748(08)00120-3journal_volume
38pub_type
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journal_title:Insect biochemistry and molecular biology
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journal_title:Insect biochemistry and molecular biology
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doi:10.1016/j.ibmb.2009.01.002
更新日期:2009-04-01 00:00:00
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journal_title:Insect biochemistry and molecular biology
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Insect biochemistry and molecular biology
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doi:10.1016/0965-1748(95)00024-p
更新日期:1995-07-01 00:00:00
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journal_title:Insect biochemistry and molecular biology
pub_type: 杂志文章
doi:10.1016/j.ibmb.2018.06.001
更新日期:2018-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Insect biochemistry and molecular biology
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pub_type: 杂志文章,评审
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journal_title:Insect biochemistry and molecular biology
pub_type: 杂志文章
doi:10.1016/j.ibmb.2009.06.001
更新日期:2009-08-01 00:00:00
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journal_title:Insect biochemistry and molecular biology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.ibmb.2020.103392
更新日期:2020-07-01 00:00:00