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The molecular mechanisms of cuticular melanization: the ecdysone cascade leading to dopa decarboxylase expression in Manduca sexta.

Abstract：

:Many insect developmental color changes are known to be regulated by both ecdysone and juvenile hormone. Yet the molecular mechanisms underlying this regulation have not been well understood. This review highlights the hormonal mechanisms involved in the regulation of two key enzymes [dopa decarboxylase (DDC) and phenoloxidase] necessary for insect cuticular melanization, and the molecular action of 20-hydroxyecdysone on various transcription factors leading to DDC expression at the end of a larval molt in Manduca sexta. In addition, the ecdysone cascade found in M. sexta is compared with that of other organisms.

journal_name

Insect Biochem Mol Biol

journal_title

Insect biochemistry and molecular biology

authors

Hiruma K,Riddiford LM

doi

10.1016/j.ibmb.2009.01.008

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

245-53

issue

4

eissn

0965-1748

issn

1879-0240

pii

S0965-1748(09)00011-3

journal_volume

39

pub_type

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