Proton MR spectroscopy of the foramen of Monro region in patients with tuberous sclerosis complex.

Abstract:

PURPOSE:To evaluate with 1H-magnetic resonance spectroscopy (MRS) the metabolites rations of the foramen of Monro's region in patients with tuberous sclerosis complex (TSC). METHOD:Twelve patients with TSC and an age and gender-matched control group underwent MR imaging at a 1.5T scanner, and 1H-MRS at the foramen of Monro level with a multivoxel acquisition. Similar volumes of interest were selected in each side of the foramen of Monro and in the basal ganglia (lentiform nuclei). The obtained N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) peak amplitude values and ratios were studied. The statistical analysis was performed and p<0.05 was considered statically significant. RESULTS:There was no significant difference between the NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of the TSC patients compared with the controls (p>0.05). CONCLUSION:The NAA/Cr and Cho/Cr ratios near to the foramen of Monro and basal ganglia of TSC patients are similar to the rations obtained in the control group.

journal_name

Arq Neuropsiquiatr

authors

Carvalho-Neto Ad,Bruck I,Antoniuk SA,Marchiori E,Gasparetto EL

doi

10.1590/s0004-282x2008000300003

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

303-7

issue

2B

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2008000300003

journal_volume

66

pub_type

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