Abstract:
:In a population-based case-control study carried out in Adelaide, South Australia, during the years 1984-1987, the diets of 104 cases of cancer of the pancreas 1 year prior to diagnosis were compared with the diets of 253 community controls. A quantitative food-frequency questionnaire was used to assess usual dietary intakes of 179 food items. Cases were compared with controls in terms of both the amounts of individual food items consumed and the estimated contributions of 48 nutrients to the diet. Food items consumed more by cases than controls included boiled eggs and omelettes as well as a number of items that could be collectively described as sweet and fatty. Food items consumed less by cases than controls included several vegetables and fruits. Conditional logistic regression analysis of nutrient intake adjusted for total energy and for alcohol and tobacco usage yielded an estimate of relative risk of 3.19, with a 95% confidence interval of 1.58-6.47 for the highest quartile of cholesterol intake (relative to the lowest quartile). For the top quartile of refined sugar intake, the estimated relative risk was 2.21 (95% confidence interval 1.07-4.55). Several nutrients derived principally from plant foods were statistically significantly associated with lower risks. Alcohol consumption was significantly lower among cases than controls. Current smokers had a relative risk of 1.76 (95% confidence interval 0.93-3.34) relative to those who had never smoked. There was no association of pancreatic cancer with coffee drinking.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Baghurst PA,McMichael AJ,Slavotinek AH,Baghurst KI,Boyle P,Walker AMdoi
10.1093/oxfordjournals.aje.a116069subject
Has Abstractpub_date
1991-07-15 00:00:00pages
167-79issue
2eissn
0002-9262issn
1476-6256journal_volume
134pub_type
杂志文章abstract::In anticipation of the sequencing of the human genome and description of the human proteome, the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik) was initiated in 2002. AGES-Reykjavik was designed to examine risk factors, including genetic susceptibility and gene/environment interaction, in relati...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwk115
更新日期:2007-05-01 00:00:00
abstract::Although missing outcome data are an important problem in randomized trials and observational studies, methods to address this issue can be difficult to apply. Using simulated data, the authors compared 3 methods to handle missing outcome data: 1) complete case analysis; 2) single imputation; and 3) multiple imputatio...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwr302
更新日期:2012-02-01 00:00:00
abstract::Data from a Norwegian investigation on family planning were used to study the relation between menarcheal age and spontaneous abortion rate. Abortion rates were found to be 1.5-2 times higher among women with a menarcheal age of 12 years or less than among those with a menarcheal age of 14 years or more. The possibili...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112953
更新日期:1980-06-01 00:00:00
abstract::A cohort of 3,916 Swedish copper smelter workers employed for at least 3 months between 1928 and 1967 was followed up through 1981. Arsenic exposure was estimated for different time periods at each workplace within the smelter. Detailed job records were linked to the exposure matrix, thus forming individual cumulative...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116128
更新日期:1991-09-15 00:00:00
abstract::Studies have documented that age at immigration and generational status are important predictors of socioeconomic outcomes among children of immigrants. Whether these characteristics are related to long-term risk of death is unknown. Leveraging variation within sibships, we evaluated the association of age at immigrat...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwz055
更新日期:2019-07-01 00:00:00
abstract::The authors examined the relation between 50 widely used agricultural pesticides and lung cancer incidence in the Agricultural Health Study, a prospective cohort study of 57,284 pesticide applicators and 32,333 spouses of farmer applicators with no prior history of lung cancer. Self-administered questionnaires were co...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwh290
更新日期:2004-11-01 00:00:00
abstract::The methods used for selecting subjects yield three types of case-control studies: 1) incident cases are compared to non-cases chosen to be representative of the exposure distribution among the person-years which produced the cases. In this type of study the exposure-odds ratio equals the incidence density ratio; 2) i...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112614
更新日期:1978-09-01 00:00:00
abstract::Two families of gorillas, comprising 13 animals, were studied in 1980-1982 for hepatitis virus infections. It was found that 27% of them had evidence of hepatitis B infection, and 23% evidence of hepatitis A infection. The four parents had been born in the wild and all of them had been infected with hepatitis B. The t...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113760
更新日期:1984-03-01 00:00:00
abstract::We estimated associations between neighborhood supermarket gain or loss and glycemic control (assessed by glycated hemoglobin (HbA1c) values) in patients from the Kaiser Permanente Northern California Diabetes Registry (n = 434,806 person-years; 2007-2010). Annual clinical measures were linked to metrics from a geogra...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwx017
更新日期:2017-06-15 00:00:00
abstract::Calcium and dairy foods in relation to prostate cancer were examined in the National Institutes of Health (NIH)-AARP (formerly known as the American Association of Retired Persons) Diet and Health Study (1995/1996-2001). Diet was assessed with a food frequency questionnaire at baseline. Multivariate relative risks and...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm268
更新日期:2007-12-01 00:00:00
abstract::Data derived from laboratory investigations suggest that a number of dietary variables may contribute to bladder carcinogenesis. Although bladder cancer is the fourth leading cause of cancer in men in the United States, dietary studies are few. The authors examined the relations between intakes of macro- and micronutr...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/152.12.1145
更新日期:2000-12-15 00:00:00
abstract::Differences in hygienic habits and base-line secretory immunoglobulin (Ig) A which might have contributed to the prevalence of skin infections and/or absence of increased serum IgA values were sought in patients with poststreptococcal acute glomerulonephritis (nephritis) in contrast to patients with acute rheumatic fe...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a113382
更新日期:1982-06-01 00:00:00
abstract::Experiencing discrimination is associated with poor mental health, but how cumulative experiences of perceived interpersonal discrimination across attributes, domains, and time are associated with mental disorders is still unknown. Using data from the Study of Women's Health Across the Nation (1996-2008), we applied l...
journal_title:American journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/aje/kwx326
更新日期:2018-05-01 00:00:00
abstract::What is the influence of various methods of handling missing data (complete case analyses, single imputation within and over trials, and multiple imputations within and over trials) on the subgroup effects of individual patient data meta-analyses? An empirical data set was used to compare these five methods regarding ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm341
更新日期:2008-03-01 00:00:00
abstract::Eating disorders are a leading cause of disease burden among young women. This study investigated associations of social characteristics of parents and grandparents, sibling position, and school performance with incidence of eating disorders. The authors studied Swedish females born in 1952-1989 (n = 13,376), third-ge...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp166
更新日期:2009-09-01 00:00:00
abstract::A large, population-based case-control study of facial clefts was carried out in Norway between 1996 and 2001. The study included 573 cases -- 377 with cleft lip with or without cleft palate and 196 with cleft palate only -- and 763 randomly selected controls. Maternal consumption of coffee and other caffeine-containi...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp040
更新日期:2009-05-15 00:00:00
abstract::Empiric data on recruitment of minorities into clinical or population studies are limited. The authors evaluated population- and community-based recruitment methods in a 1998-2001 case-control study of lung cancer among African Americans and Latinos. For lung cancer cases in the San Francisco Bay Area of California, r...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwg138
更新日期:2003-08-01 00:00:00
abstract::Trends in sexual behavior associated with incident infection with human immunodeficiency virus (HIV) type 1 are described and a case-control study was conducted to examine risk factors for HIV seroconversion in homosexual men who became infected with HIV between 1982 and 1994 from four geographic sites: Amsterdam, the...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a009311
更新日期:1997-10-01 00:00:00
abstract::Influenza-like illness data are collected via an Influenza Sentinel Provider Surveillance Network at the state level. Because participation is voluntary, locations of the sentinel providers may not reflect optimal geographic placement. The purpose of this study was to determine the "best" locations for sentinel provid...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwp270
更新日期:2009-11-15 00:00:00
abstract::Outbreaks of respiratory tract illnesses (RTI) in adult humans during October and November 1975 at McMurdo Station, Antarctica, were investigated by viral isolation and serologic procedures. The recovery of viral agents was enhanced by use of cell cultures in the field. Recoveries of parainfluenzaviruses types 1 and 3...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a112857
更新日期:1979-12-01 00:00:00
abstract::Standardization procedures are commonly used to combine phenotype data that were measured using different instruments, but there is little information on how the choice of standardization method influences pooled estimates and heterogeneity. Heterogeneity is of key importance in meta-analyses of observational studies ...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kww098
更新日期:2016-11-15 00:00:00
abstract::Case-control differences in prediagnostic serum levels of retinol, beta-carotene, vitamin E, and selenium are compared for 10 cancer sites in 10 study populations. For all four nutrients, the majority of results showed lower levels among persons who subsequently became cases than among controls. Low levels of beta-car...
journal_title:American journal of epidemiology
pub_type: 临床试验,杂志文章,多中心研究,评审
doi:10.1093/oxfordjournals.aje.a116264
更新日期:1992-01-15 00:00:00
abstract::The relation of blood pressure, serum cholesterol, plasma fibrinogen, and coagulation factor VIIc with skinfold thickness at four sites (forearm, triceps, suprailiac, and subscapular) was examined in 2,948 white participants in the Northwick Park Heart Study. When considered separately, all four skinfolds were signifi...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114665
更新日期:1987-07-01 00:00:00
abstract::Semen quality has been suggested to be a biological marker of long-term morbidity and mortality; however, few studies have been conducted on this subject. We identified 5,370 men seen for infertility at Frederiksberg Hospital, Denmark, during 1977-2010, and 4,712 of these men were followed in the Danish National Patie...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwx067
更新日期:2017-10-15 00:00:00
abstract::Vitamin C has been the focus of epidemiologic investigation in preterm delivery (<37 weeks' gestation), which is a leading cause of neonatal mortality and birth-related morbidity. There are two sodium-dependent membrane transporters encoded by SLC23A1 and SLC23A2, which have key roles in human vitamin C metabolism and...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwj035
更新日期:2006-02-01 00:00:00
abstract::A matched case-control study was conducted of 53 leukemia deaths and of 212 controls within a previously studied cohort of 24,545 on-shore workers employed between January 1, 1952 and August 15, 1977 at the Portsmouth (New Hampshire) Naval Shipyard. The study sought to ascertain a priori whether there was an associati...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114350
更新日期:1986-06-01 00:00:00
abstract::Periconceptional intake of folic acid prevents some neural tube defects (NTDs). Other nutrients may also contribute to NTD etiologies; a likely candidate is choline. Similar to folic acid, choline is involved in one-carbon metabolism for methylation of homocysteine to methionine. The authors investigated whether mater...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwh187
更新日期:2004-07-15 00:00:00
abstract::Occupational and leisure time physical activity and conventional risk factors were determined in the Belgian Physical Fitness Study, a prospective study of 2,363 healthy male factory workers who were aged 40-55 years at entry in 1976-1978 and who were followed for five years. Physical fitness, defined as the interpola...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a114573
更新日期:1987-04-01 00:00:00
abstract::A case-control study investigated the relation between cigarette smoking and histologic subtypes of adult leukemia in Missouri in 1984-1990. Among males, elevated risks associated with ever smoking were observed for acute nonlymphocytic leukemia (odds ratio (OR) = 1.5; 95% confidence interval (CI) 1.1-2.0) and acute m...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/oxfordjournals.aje.a116177
更新日期:1991-11-01 00:00:00
abstract::Physical functioning measures are considered integrated markers of the aging process. This prospective investigation examined relations between dietary intake of women at midlife in 1996-1997 and prevalence of physical functioning limitations 4 years later, defined by the Medical Outcomes Study Short-Form 36. The samp...
journal_title:American journal of epidemiology
pub_type: 杂志文章
doi:10.1093/aje/kwm397
更新日期:2008-04-15 00:00:00