Is formocresol obsolete? A fresh look at the evidence concerning safety issues.

Abstract:

:Concern has been expressed about the safety of formocresol use in pediatric dentistry Formaldehyde, a primary component in formocresol, is a hazardous substance and is considered a probable human carcinogen by the International Agency for Research on Cancer, Health Canada, the Agency for Toxic Substances and Disease Registry in the U.S. Department of Health and Human Services, and the U.S. Environmental Protection Agency Humans inhale and ingest formaldehyde daily however, and produce formaldehyde during cellular metabolism. The human body is physiologically equipped to handle formaldehyde through multiple conversion pathways. The resultant single carbon atom released during metabolism is deposited in the "1-carbon pool," which, in turn, is used for the biosynthesis of macromolecules including DNA and RNA. Reevaluation of earlier research that examined potential health risks associated with formaldehyde exposure has shown that this research was based on flawed assumptions, which resulted in erroneous conclusions. The purpose of this review was to examine more recent research about formaldehyde metabolism, phormacokinetics, and corcinogenicity. These results indicated that formaldehyde is probably not a potent human carcinogen under low exposure conditions. Extrapolation of these research results to pediatric dentistry suggests an inconsequential risk associated with formaldehyde use in pediatric pulp therapy/

journal_name

Pediatr Dent

journal_title

Pediatric dentistry

authors

Milnes AR

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

237-46

issue

3

eissn

0164-1263

issn

1942-5473

journal_volume

30

pub_type

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