Abstract:
:The combination piperaquine and dihydroartemisinin is emerging as first line treatment of uncomplicated falciparum malaria in Southeast Asia. The aim of this study was to determine the influence of a standard Vietnamese meal on the single-dose pharmacokinetics of piperaquine when administered in combination with dihydroartemisinin, and to gain extended data on the terminal half-life of piperaquine in healthy Vietnamese volunteers. Subjects were randomly assigned to take a single oral dose of piperaquine phosphate (640 mg)+dihydroartemisinin (80 mg) together with a standardized Vietnamese meal (n=16) or to remain fasting for 4h following drug intake (n=16). Frequent blood sampling was conducted during 36 h, followed by weekly samples for 7 weeks. The pharmacokinetic parameters of piperaquine were determined by noncompartmental analysis. The median (80% central range) AUC(0-last) was 11.5 (6.9-17.3)h mg/L in fed and 13.9 (2.8-19.3)h mg/L in fasting subjects, indicating a considerable variability in exposure in both groups. The estimated overall oral clearance was 0.27 (0.12-1.49)L/(h kg), the volume of distribution during the terminal elimination phase was 230 (102-419)L/kg and estimated terminal half-life was 18 (5-93) days. This study did not demonstrate a significant impact of a standardized Vietnamese meal on the oral absorption of piperaquine.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Hai TN,Hietala SF,Van Huong N,Ashton Mdoi
10.1016/j.actatropica.2008.05.013subject
Has Abstractpub_date
2008-08-01 00:00:00pages
145-9issue
2eissn
0001-706Xissn
1873-6254pii
S0001-706X(08)00148-4journal_volume
107pub_type
杂志文章相关文献
ACTA TROPICA文献大全abstract::Chronic malaria severely affects the immune system and causes polyclonal B-cell activation, as evidenced by the presence of hypergammaglobulinemia, elevated levels of autoantibodies, loss of B-cell memory and the frequent occurrence of Burkitt's lymphomas (BL) in children living in malaria endemic areas. Previous stud...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2011.05.005
更新日期:2011-08-01 00:00:00
abstract::In all, 40 native triatomine species and subspecies occur in NA, belonging to six genera from the Triatomini (Triatoma, Paratriatoma, Panstrongylus, Dipetalogaster, Belminus, Eratyrus), and one genus from the Rhodniini (represented by one non-native species Rhodnius prolixus, formerly occurring exclusively in domestic...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2008.11.012
更新日期:2009-05-01 00:00:00
abstract::Assessing the biting behaviour of malaria vectors plays an integral role in understanding the dynamics of malaria transmission in a region. Biting times and preference for biting indoors or outdoors varies among mosquito species and across regions. These behaviours may also change over time in response to vector contr...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2019.105059
更新日期:2019-09-01 00:00:00
abstract::Opisthorchis viverrini infection, opisthorchiasis, is a food-borne trematodiasis that is the main cause of cholangiocarcinoma, a bile duct cancer, in the Lower Mekong sub-region of Lao PDR, Cambodia, Vietnam, and Thailand. Despite extensive research on opisthorchiasis, the eradication of this disease has yet to be ach...
journal_title:Acta tropica
pub_type: 杂志文章,评审
doi:10.1016/j.actatropica.2019.05.011
更新日期:2019-08-01 00:00:00
abstract::30 Trypanosoma cruzi strains isolated from chronic chagasic patients were studied at the genotype level by RAPD with arbitrary primers and SSR-PCR analysis. The genetic distance of strains was measured by the percentage of unshared bands. The results showed that the strains isolated from chronic patients from differen...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(97)00122-8
更新日期:1998-05-01 00:00:00
abstract::A schistosomiasis control project was undertaken from 1994 to 1998 in Guruve District, Zimbabwe, based on the active involvement of local communities in the growing and application of the molluscicidal plant Phytolacca dodecandra as a supplement to other control measures such as chemotherapy and health education. The ...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(02)00256-5
更新日期:2003-03-01 00:00:00
abstract::A study on the potential of houseflies (Musca domestica L.) to spread fungal spores in Gauteng Province, South Africa proved that houseflies are vectors for fungal spores. Therefore, there is a need to determine the toxigenic potentials and to identify the mycotoxins produced by fungal isolates derived from this study...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2016.12.037
更新日期:2017-04-01 00:00:00
abstract::We report the pattern of infection of Glossina pallidipes with Trypanosoma vivax and T. congolense at a site in the Coast region of eastern Tanzania, studied between November 1993 and December 1994. Of the 2315 flies dissected 114 (4.9%) were T. congolense positive, 77 (3.3%) were T. vivax positive and 2 (0.1%) were T...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(98)00013-8
更新日期:1998-06-30 00:00:00
abstract::Dipterans, especially the sarcosaprophagous communities are of substantial importance from medical, veterinary and forensic entomological perspectives. Muscids are generally seen to colonize carcasses at advanced stages of decomposition when the initial dominance of calliphorids and sarcophagids subsides. Ophyra capen...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2018.06.023
更新日期:2018-09-01 00:00:00
abstract::Loop-mediated isothermal amplification (LAMP) is a novel molecular method that accelerates and facilitates DNA amplification and detection under isothermal conditions. It represents a revolution in molecular biology by reducing the high cost, turnaround time and technicality of polymerase chain reaction and other ampl...
journal_title:Acta tropica
pub_type: 杂志文章,评审
doi:10.1016/j.actatropica.2012.02.004
更新日期:2012-06-01 00:00:00
abstract::Free Living Amoebae (FLA) of Acanthamoeba genus are widely distributed in the environment and can be found in the air, soil and water; and have also been isolated from air-conditioning units. In humans, they are causative agents of a sight-threating infection of the cornea, Acanthamoeba keratitis (AK) and a fatal infe...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2013.10.006
更新日期:2014-02-01 00:00:00
abstract::Azithromycin, an azalide analog of erythromycin was assayed for its in vitro activity against multidrug-resistant Plasmodium falciparum K1 strain by measuring the 3H-hypoxanthine incorporation. Azithromycin caused inhibitory effects on the parasite growth with IC50 and IC90 values of 8.4+/-1.2 microM and 26.0+/-0.9 mi...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2006.10.008
更新日期:2006-12-01 00:00:00
abstract::The aetiology of zoonotic infections embraces organisms from every branch of the microbial world. In addition, zoonoses must be considered as a truly global problem, both in terms of their distribution and the measures required for their control. Within the UK, zoonotic disease is considered to be less frequent than i...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(00)00093-0
更新日期:2000-07-21 00:00:00
abstract::Erythema Nodosum Leprosum (ENL) occurs due to the immunological complication of multibacillary leprosy and is characterized by painful nodules and systemic compromising. It is usually recurrent and/or chronic and has both physical and economic impact on the patient, being a very important cause of disability. In addit...
journal_title:Acta tropica
pub_type: 杂志文章,评审
doi:10.1016/j.actatropica.2018.02.026
更新日期:2018-07-01 00:00:00
abstract::Cutaneous leishmaniasis (CL) is an emerging neglected tropical disease in Azad Jammu and Kashmir which is an underdeveloped area. Prevalence and parasite species identification are the key factors to control disease in a particular population, which were the objectives of the present study. Due to a lack of previous d...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2020.105434
更新日期:2020-06-01 00:00:00
abstract::Toxoplasmosis is a common and serious parasitic disease with high prevalence and global distribution in human and other warm-blooded vertebrates. Though the infection of Toxoplasma gondii is usually asymptomatic in healthy people, it can lead to severe pathological effects to the fetus of infected women and immunocomp...
journal_title:Acta tropica
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.actatropica.2016.03.003
更新日期:2016-06-01 00:00:00
abstract::Phenanthridine trypanocides (isometamidium chloride hydrochloride, ISM, and Ethidium bromide, EBr) have been widely used to treat African trypanosomiasis in livestock for more than 40 years. Their main action is to inhibit nucleic acid synthesis in trypanosome parasites, by intercalation between the DNA base pairs. Th...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(02)00188-2
更新日期:2002-12-01 00:00:00
abstract::As part of a study to assess zoonotic milk-borne health risks, seasonal survey data and unpasteurized milk samples were collected between January 1999 and February 2000 from randomly selected informal milk market agents (220 and 236 samples in the dry and wet seasons, respectively) and from households purchasing raw m...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2005.05.012
更新日期:2005-10-01 00:00:00
abstract::Chandipura virus (CHPV) is an arthropod borne rhabdovirus associated with acute encephalitis in children below the age of 15 years in the tropical states of India. Although the entry of the virus into the nervous system is among the crucial events in the pathogenesis of CHPV, the exact mechanism allowing CHPV to invad...
journal_title:Acta tropica
pub_type: 杂志文章,评审
doi:10.1016/j.actatropica.2014.03.028
更新日期:2014-07-01 00:00:00
abstract::Proteins in Schistosoma haematobium infected human urine were concentrated by precipitation with saturated ammonium sulphate 50% (v/v) and various fractions obtained at different stages of precipitation tested for presence of schistosome antigens (ShAgs) by dot-ELISA. The protein fraction (UP2S) obtained following two...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/s0001-706x(96)00040-x
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Mosquitoes are responsible for spreading many diseases and their populations are susceptible to environmental changes. The ecosystems in the Three Gorges Region were probably altered because of changes to the environment during the construction of the Three Gorges Dam (TGD), the world's largest hydroelectric...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2018.03.008
更新日期:2018-06-01 00:00:00
abstract::The vector species Aedes albopictus (Skuse, 1894) was recorded in Turkey for the first time, near the Greek border, in 2011 and a high risk of expansion towards Aegean and Mediterranean coasts of Turkey was estimated. A preliminary study was planned to evaluate the possibility of creating a satellite mass rearing faci...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2016.03.032
更新日期:2016-07-01 00:00:00
abstract::The population dynamics of the larval and adult life stages of the malaria vector Anopheles gambiae Giles were studied in Miwani, western Kenya, in relation to meteorological conditions. Larval density within a habitat, the number of larval habitats and sibling species composition were investigated as determinants of ...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2003.11.007
更新日期:2004-04-01 00:00:00
abstract::We compared age-related seroprevalence of Trypanosoma cruzi infection with history of vector control interventions and social and ecological changes in three historically endemic departments of Cordoba province, Argentina, covering an area of 42,600 km(2) of the Gran Chaco region. Using a cross sectional design, blood...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2009.11.007
更新日期:2010-03-01 00:00:00
abstract::Flight dispersion is recognized as one of the most important mechanisms for triatomine house infestation. Triatoma sherlocki and T. juazeirensis are closely related species that occur within the same ecotope and their possible reproductive boundaries are unknown. T. sherlocki has shorter wings than T. juazeirensis; a ...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2011.12.001
更新日期:2012-04-01 00:00:00
abstract::A case of ectopic lesion of Schistosoma haematobium of the penis with extensive tissue destruction, simulating an early carcinoma of the penis and almost resulting in an autoamputation of the crown of the penis, is presented. The penis was surgically repaired and the patient treated with ambilhar. In schistosoma endem...
journal_title:Acta tropica
pub_type: 杂志文章
doi:
更新日期:1978-09-01 00:00:00
abstract::A randomized controlled trial was carried out in Assab under the auspices of the National Organization for the Control of Malaria and other Vectorborne Diseases of Ethiopia to assess the effectiveness of an indigenous cyprinodontid fish, Aphanius dispar, in controlling mosquito larvae, including the local malaria vect...
journal_title:Acta tropica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0001-706x(92)90032-s
更新日期:1992-12-01 00:00:00
abstract::We focused on the epidemiology of alveolar echinococcosis especially in Japan and discussed control measures to prevent an epidemic. No effective control measures against alveolar echinococcosis have been identified thus far because it is difficult to fully understand the ecology of the parasite and its hosts, i.e. th...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2003.09.001
更新日期:2003-12-01 00:00:00
abstract::Houseflies (Musca domestica) spend part of their life development on animal or human manure. Manure is high in pathogenic microbes; thus, houseflies have been known as a mechanical vector for various important zoonotic diseases. Therefore, the present study showcases captured houseflies from intensive swine production...
journal_title:Acta tropica
pub_type: 杂志文章
doi:10.1016/j.actatropica.2018.04.024
更新日期:2018-09-01 00:00:00
abstract::The surface coat of the protozoan parasite Leishmania affords remarkable protection in the harsh environments encountered within the insect vectors and vertebrate hosts. It also provides specificity for the interaction of these parasites with the cells in the sandfly gut and with the human macrophage. Surprisingly few...
journal_title:Acta tropica
pub_type: 杂志文章,评审
doi:10.1016/0001-706x(93)90029-b
更新日期:1993-05-01 00:00:00