Abstract:
OBJECTIVES:To relate diabetes mellitus (DM) status and duration to late-life cognitive impairment and decline in men and women. DESIGN:Prospective cohort. SETTING:Community. PARTICIPANTS:Five thousand nine hundred seven men in the Physicians' Health Study II and 6,326 women in the Women's Health Study (mean age 74.1 and 71.9, respectively, at baseline cognitive assessment); 553 men and 405 women had DM. MEASUREMENTS:Primary outcomes were general cognition (the Telephone Interview for Cognitive Status (TICS) and a global score averaging five tests) and verbal memory. All participants had second assessments approximately 2 years later; women had third assessments an average of 4 years later. RESULTS:In adjusted linear regression models, participants with DM had significantly lower baseline scores for all outcomes, and longer duration of DM was associated with lower scores (P-trends < .001). Men with DM had significantly greater 2-year cognitive decline than men without DM, and longer duration of DM was associated with worse decline (P-trends < or = .01). In repeated-measures analyses of response profiles, women with DM had significantly greater 4-year cognitive decline in all outcomes than women without DM. In women, as in men, there was generally greater cognitive decline with longer duration of DM (e.g., the adjusted mean difference in decline on the TICS associated with duration of > or = 5 years was -0.74 (95% confidence interval = -1.05 to -0.43) points (P-trend < .001). There were no significant sex-DM interactions. CONCLUSION:Type 2 DM and longer duration of DM are similarly related to cognitive impairment and decline in men and women.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Okereke OI,Kang JH,Cook NR,Gaziano JM,Manson JE,Buring JE,Grodstein Fdoi
10.1111/j.1532-5415.2008.01686.xsubject
Has Abstractpub_date
2008-06-01 00:00:00pages
1028-36issue
6eissn
0002-8614issn
1532-5415pii
JGS1686journal_volume
56pub_type
杂志文章,多中心研究abstract:OBJECTIVES:To assess whether catheter replacement is associated with better clinical outcomes in individuals with long-term urinary catheters. DESIGN:Prospective, noninterventional study. PARTICIPANTS:Individuals (mean age 79.2±11.5) who had had an indwelling urinary catheter for longer than 7 days and a symptomatic ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15517
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To compare clinical status of elderly institutionalized subjects with asymptomatic bacteriuria and normal urinary antibody to those with elevated urinary antibody to the major outer membrane of Escherichia coli. DESIGN:Retrospective review. SETTING:Long term facility for the elderly. PARTICIPANTS:Convenien...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1992.tb02112.x
更新日期:1992-06-01 00:00:00
abstract:OBJECTIVES:To determine whether urinary incontinence (UI) is an independent predictor of death, nursing home admission, decline in activities of daily living (ADLs), or decline in instrumental activities of daily living (IADLs). DESIGN:A population-based prospective cohort study from 1993 to 1995. SETTING:Community-d...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2004.52207.x
更新日期:2004-05-01 00:00:00
abstract::The stage of a cancer at diagnosis is multiply determined, theoretically depending on such disparate factors as tumor biology, patient education, and physician behaviors. Data from all Hispanic and non-Hispanic white residents of New Mexico diagnosed with a malignancy from 1969 through 1982 were analyzed to determine ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1986.tb06335.x
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:To investigate the association between blood pressure and mortality in very old people. DESIGN:Population-based cohort study. SETTING:County of Västerbotten, Sweden. PARTICIPANTS:Half of all subjects aged 85 and all of those aged 90 and 95 and older (N=348) in one urban and five rural municipalities in th...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2008.01948.x
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVES:To determine the effect of four vitamin D supplement doses on falls risk in elderly nursing home residents. DESIGN:Secondary data analysis of a previously conducted randomized clinical trial. SETTING:Seven hundred twenty-five-bed long-term care facility. PARTICIPANTS:One hundred twenty-four nursing home r...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1532-5415.2007.01048.x
更新日期:2007-02-01 00:00:00
abstract::Physical health problems become more common as people age and are associated with a great deal of disability. Although racial and ethnic disparities have been reported in physical health, little is known about whether these disparities remain in the latest part of older adulthood. Accordingly, the current study sought...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2010.03033.x
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was fourfold; to determine the rate of delirium among hospitalized older persons, to contrast the clinical outcomes of patients with and without delirium, to identify clinical predictors of delirium, and to validate the predictive model in an independent sample of patients. DESIGN:T...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1994.tb06551.x
更新日期:1994-08-01 00:00:00
abstract::Cognitive function is often impaired in type I diabetes mellitus, especially when onset is in early childhood. Limited evidence suggests similar impairment in the much larger population of older persons with type II diabetes. We report here the results of 13 measures of mental efficiency in persons between 65 and 77 y...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1990.tb02398.x
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVES:To examine whether the total burden of comorbidity and pattern of co-occurring conditions varies in individuals with heart failure (HF) with preserved left ventricular ejection fraction (LVEF) (HF-P) or HF with reduced LVEF (HF-R). DESIGN:Cross-sectional cohort study. SETTING:Four participating health plan...
journal_title:Journal of the American Geriatrics Society
pub_type: 历史文章,杂志文章,多中心研究
doi:10.1111/jgs.12062
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Mammographic screening for breast cancer is of uncertain clinical benefit for women 75 years of age and older. Some have argued against instituting routine screening in this age group, noting that disability and shorter life expectancy may diminish the desirability and cost-effectiveness of sc...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1998.tb02746.x
更新日期:1998-08-01 00:00:00
abstract::The treatment of cerebrovascular insufficiency and its many symptoms in the ever-increasing numbers of the aged, is of major concern to physicians engaged in such care. Despite past skepticism as to the degree of efficacy of cerebral vasodilators, there is renewed interest in this form of therapy. Our investigation wa...
journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章
doi:10.1111/j.1532-5415.1977.tb00840.x
更新日期:1977-12-01 00:00:00
abstract:OBJECTIVES:To examine the relationship between total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and the incidence of coronary heart disease (CHD) in elderly men. DESIGN:Prospective. SETTING:Population based. PARTICIPANTS:A sample of 2,424, Japanese-American men aged 71 to 93 was used. MEASUREM...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2004.52551.x
更新日期:2004-12-01 00:00:00
abstract::Aortic systolic murmurs and aortic dilatation were studied in a randomized sample of 100 hospital patients over the age of 60. Clinical, phonocardiographic, radiologic and carotid-pulse data provided the basis for graphic characterization of the murmurs. Senile aortic dilatation was common (66 patients). In a high per...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1976.tb03314.x
更新日期:1976-08-01 00:00:00
abstract::Widowed residents of two nursing homes who were oriented to person, time, and place were interviewed to determine the extent to which they had hallucinatory experiences of their deceased spouse. Fifty-two interviews were completed with 46 widows and six widowers. Results are reported for the widows. Twenty-eight (61%)...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1985.tb04619.x
更新日期:1985-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Little is known about elder abuse and neglect in the lesbian, gay, bisexual, and transgender (LGBT) community; however, this population faces a greater risk of abuse and likely experiences abuse differently and needs different resources. We conducted focus groups to investigate LGBT older adults' ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究
doi:10.1111/jgs.16101
更新日期:2019-11-01 00:00:00
abstract::Cerebral blood flow (CBF) was measured by the 133Xe inhalation method in patients with multi-infarct dementia (MID, N = 26), Alzheimer's dementia (AD, N = 19), and among age-matched, neurologically normal, healthy volunteers (N = 26). Cognitive performance was assessed in all subjects using the Cognitive Capacity Scre...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1986.tb04318.x
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVES:To study how well the scoring on each item of the MMSE relates to the sum-score when the purpose is to identify persons with cognitive impairment, and to identify an equally effective subset of MMSE items for predicting cognitive impairment. DESIGN:Retrospective survey of MMSE data for 850 elderly. SETTING...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1992.tb01804.x
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVES:Patients undergoing hip fracture surgery have a 10 times increased risk of stroke compared with the general population. We aimed to evaluate the association between the CHA2 DS2 -VASc (congestive heart failure, hypertension, age ≥75 years, diabetes, previous stroke/TIA [transient ischemic attack]/systemic em...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16452
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To determine if home environmental hazards increase the risk of fall injury events among community-dwelling older persons. DESIGN:Population-based case-control study. SETTING:South Miami Beach, Florida. PARTICIPANTS:270 persons aged 65 years and older who sought treatment at six area hospitals for injuries...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1998.tb03799.x
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVES:Heart failure is a major health care burden among older adults, but information on recent trends has not been available. We compare rates, sociodemographic characteristics, and discharge outcomes of the initial hospitalization for heart failure in the Medicare populations of 1986 and 1993. DESIGN:Informatio...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1997.tb00939.x
更新日期:1997-03-01 00:00:00
abstract::The term "plastic surgeon" is oddly uninformative, although it seems likely that most people know what plastic surgeons do. How well can a sample of individuals encountered on the street describe what geriatricians do? To answer this question, we strolled through downtown Baltimore's Inner Harbor, armed with a video c...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.12115
更新日期:2013-03-01 00:00:00
abstract::The aim of this study was to evaluate the usefulness of Silver's Cerebral Function Test in predicting the management and placement of patients admitted to a psychogeriatric hospital. Overall, 205 consecutively admitted patients and 54 age-matched controls living in the community were examined, thereby greatly extendin...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1977.tb00409.x
更新日期:1977-06-01 00:00:00
abstract:OBJECTIVE:To create a program to identify preventive needs for community-dwelling older persons and incorporate intervention strategies to improve implementation of these services. DESIGN:Program development and case-series. SETTING:Community-based meal sites, academically administered program. PARTICIPANTS:Persons ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1996.tb01416.x
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVES:To compare clinical and economic outcomes of early insulin initiation with those of delayed initiation in older adults with type 2 diabetes mellitus (T2DM). DESIGN:Retrospective cohort study. SETTING:Humana Medicare Advantage health insurance plan. PARTICIPANTS:Older (≥65) Medicare beneficiaries with T2DM...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.13388
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:To determine the effect of patient characteristics and of specific guidelines that were developed for managing warfarin therapy in older adults and included in an in-house computer program on anticoagulation quality. DESIGN:Thirteen-month observational study. SETTING:Acute care, extended care, and rehabili...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2009.02675.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:To determine the trajectory of handgrip strength (HGS) from age 70 to 90 and its association with mood, cognition, functional status, and mortality. DESIGN:Prospective follow-up of an age-homogenous representative community-dwelling cohort (born 1920-21) in the Jerusalem Longitudinal Cohort Study (1990-2015...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.14509
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:To determine the association between complementary and alternative medicine (CAM) use and antihypertensive medication adherence in older black and white adults. DESIGN:Cross-sectional. SETTING:Patients enrolled in a managed care organization. PARTICIPANTS:Two thousand were hundred eighty black and white a...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2009.02639.x
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To describe the essential components of an Agile Implementation (AI) process, which rapidly and effectively implements evidence-based healthcare solutions, and present a case study demonstrating its utility. DESIGN:Case demonstration study. SETTING:Integrated, safety net healthcare delivery system in India...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15283
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Incontinence-specific and generic measures of well-being were regressed on potential predictors to identify incontinent respondents at risk for psychosocial distress and to understand the relationship between urinary incontinence (UI) and other determinants of social and emotional status. DESIGN:Survey data ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2001.49179.x
更新日期:2001-07-01 00:00:00