Abstract:
:Asthma is an inflammatory disease of the airways, for which many therapeutic options are available. Guidelines for the management of asthma suggest a stepwise approach to pharmacotherapy based on assessment of asthma severity and control. However, the assessment of asthma control presently relies on surrogate measures, such as the frequency of symptoms or the frequency of use of short-acting beta2-adrenergic agonists. There is no simple, noninvasive technique for the assessment of severity of actual airway inflammation in asthma. The collection and analysis of nitric oxide (NO) levels in exhaled breath has recently become feasible in humans. Based on increased exhaled NO (eNO) levels in patients with asthma, eNO analysis has been proposed as a novel, noninvasive approach to the assessment and monitoring of airway inflammation, and as a basis for adjustments in asthma therapy. In the present paper, the relationship of elevated eNO levels in asthma with inflammatory, physiological and clinical markers of asthma in adults was reviewed. Use of eNO is a promising tool for diagnosing asthma, for monitoring asthma control and for guiding optimal anti-inflammatory asthma therapy. However, because of many unresolved questions, eNO cannot be recommended at present for routine clinical management of adults with asthma.
journal_name
Can Respir Jjournal_title
Canadian respiratory journalauthors
Pendharkar S,Mehta Sdoi
10.1155/2008/463762subject
Has Abstractpub_date
2008-03-01 00:00:00pages
99-106issue
2eissn
1198-2241issn
1916-7245journal_volume
15pub_type
杂志文章,评审abstract:BACKGROUND:Inhaled corticosteroids are effective in suppressing a chronic cough without asthma associated with sputum eosinophilia. OBJECTIVE:To investigate the inflammatory characteristics in the induced sputum of patients with a chronic cough without asthma or known cause and the effects of budesonide treatment on c...
journal_title:Canadian respiratory journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1155/1999/434901
更新日期:1999-07-01 00:00:00
abstract::Physical activity is an important health behaviour in reducing morbidity and mortality in individuals with chronic obstructive pulmonary disease (COPD). Accurate measurement of the characteristics of physical activity is essential to understanding the impact of COPD on physical activity. In a previous article, we repo...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2019/2185207
更新日期:2019-09-17 00:00:00
abstract:BACKGROUND:Quantitative cell counts in sputum provide an accurate assessment of the type and severity of bronchitis. OBJECTIVE:To examine whether sputum cell counts could identify bronchiectasis in patients with recurrent bronchitis. METHODS:A retrospective survey of a clinical database (January 2004 to January 2005)...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2011/920465
更新日期:2011-07-01 00:00:00
abstract::Sarcoidosis is a rare disease characterized by granulomatous inflammation in affected organs, primarily in lungs. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are easy and practical methods providing valuable information in diagnosis, severity, and prognosis of various diseases. Here, we aimed...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2020/1696450
更新日期:2020-09-24 00:00:00
abstract::Background. Blunt chest wall trauma accounts for over 10% of all trauma patients presenting to emergency departments worldwide. When the injury is not as severe, deciding which blunt chest wall trauma patients require a higher level of clinical input can be difficult. We hypothesized that patient factors, injury patte...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2016/3257846
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Interleukin (IL)-10 is a pleiotropic cytokine released from various cells, including T cells. Although IL-10 is suggested to inhibit allergic responses, its role in asthma remains uncertain. The purpose of the present study was to compare the profile of IL-10 in circulating T cells from stable atopic asthmat...
journal_title:Canadian respiratory journal
pub_type: 临床试验,杂志文章
doi:10.1155/2004/710962
更新日期:2004-01-01 00:00:00
abstract::Chronic granulomatous disease (CGD) is a rare, polygenic primary immunodeficiency. In this case report, we describe a previously healthy 13-year-old boy who presented with multifocal pulmonary aspergillosis and was subsequently diagnosed with an autosomal recessive form of chronic granulomatous disease. CGD has a vari...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2016/4575942
更新日期:2016-01-01 00:00:00
abstract::The understanding of how inhaled allergens affect the asthmatic patient has changed significantly over the years. Allergen inhalation was first recognized as a cause of asthma in 1873, and the clinically important late asthmatic response (LAR) was demonstrated, albeit crudely, in 1952. Immunopathogenesis of the LAR wa...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:
更新日期:1998-07-01 00:00:00
abstract:Objectives:Clarithromycin is recommended as the core agent for treating M. abscessus infections, which usually calls for at least one year of treatment course, facilitating the development of resistance. This study aimed to identify the underlying mechanism of in vivo development of clarithromycin resistance in M. absc...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2020/7623828
更新日期:2020-03-28 00:00:00
abstract:BACKGROUND:Collaborative self-management is a core recommendation of national asthma guidelines; the written action plan is the knowledge tool that supports this objective. Mobile health technologies have the potential to enhance the effectiveness of the action plan as a knowledge translation tool. OBJECTIVE:To design...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2013/906710
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:St. Joseph's Health System has implemented an integrated comprehensive care bundle care (ICC) program with the hopes that it would improve patients' care while reducing overall costs. The aim of this analysis was to evaluate the performance of the ICC program within patients admitted with chronic pulmonary o...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2017/7049483
更新日期:2017-01-01 00:00:00
abstract::Solitary fibrous tumours of the pleura are rare pleural neoplasms that are distinct from mesothelioma. Most of them are benign, although some behave aggressively; morphological and pathological features are important in distinguishing them from mesothelioma and in predicting clinical behaviour. Solitary fibrous tumour...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2010/509607
更新日期:2010-05-01 00:00:00
abstract::Clearance of inhaled technetium-99m diethylenetriaminepentaacetate (99mTc-DTPA) is a potential indicator of disease activity and progression in idiopathic pulmonary fibrosis (IPF). The objective of the present study was to evaluate the prognostic value of 99mTc-DTPA scans in IPF. A total of 22 patients (18 males), age...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2004/185705
更新日期:2004-10-01 00:00:00
abstract::Background. Canadian policy requires refugees with a history of tuberculosis (TB) or abnormal chest radiograph to be screened after arrival for TB. However, Tibetan refugees are indiscriminately screened, regardless of preimmigration assessment. We sought to determine the incidence of latent (LTBI) and active TB, as w...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2016/8249843
更新日期:2016-01-01 00:00:00
abstract::Alpha-1 antitrypsin (A1AT) functions primarily to inhibit neutrophil elastase, and deficiency predisposes individuals to the development of chronic obstructive pulmonary disease (COPD). Severe A1AT deficiency occurs in one in 5000 to one in 5500 of the North American population. While the exact prevalence of A1AT defi...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,实务指引
doi:10.1155/2012/920918
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To compare the relapse rate after a single intramuscular injection of a long acting corticosteroid, betamethasone, with oral prednisone in patients discharged from the emergency department (ED) for acute exacerbations of asthma. PATIENTS AND METHODS:Patients with acute exacerbations of asthma who were suitab...
journal_title:Canadian respiratory journal
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1155/2001/613426
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Asthma education should be offered with priority to populations with the highest asthma-related morbidity. In the present study, the aim was to identify populations with high-morbidity for asthma from the Quebec Health Insurance Board Registry, a large administrative database, to help the Quebec Asthma and C...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2004/607625
更新日期:2004-09-01 00:00:00
abstract::In children with persistent asthma, inhaled glucocorticoids decrease symptoms and exacerbations, decrease the need for rescue bronchodilator medications, improve airway patency and reduce airway hyperresponsiveness. When administered in the lowest doses that prevent symptoms and eliminate the need for supplemental cou...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/1999/957127
更新日期:1999-03-01 00:00:00
abstract::A 25-year-old woman with narcolepsy and cataplexy was treated with well-recognized drugs for these conditions. Because she did not respond, a decision was made to treat her with sodium oxybate. ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,评审
doi:10.1155/2005/341295
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Asthma exacerbations can be provoked by many triggers such as allergens, respiratory irritants and viral infections. The relative importance of these has not been prospectively documented in a case-control study. OBJECTIVE:To assess the relative importance of colds and other nonclimatic historical triggers ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2000/812025
更新日期:2000-01-01 00:00:00
abstract:Objective:This epidemiological investigation aimed at determining the current situation regarding the diagnosis and treatment of chronic obstructive pulmonary disease (COPD), especially missed diagnosis and missed treatment, in a group of individuals residing in an island area of Ningbo. Methods:Adults ≥60 years of ag...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2019/6918340
更新日期:2019-08-01 00:00:00
abstract::A 30-year-old female presented shortly after cadaveric renal transplantation with respiratory distress typical of a bacterial infection. Following initial improvement, she developed progressive respiratory failure, initially felt to be secondary to cytomegalovirus infection. Two bronchoalveolar lavages were nondiagnos...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2000/248915
更新日期:2000-07-01 00:00:00
abstract::A case of azygos lobe is presented. An azygos lobe is an accessory lobe of the lung that may occasionally be confused with a pathological process such as a bulla, lung abscess or neoplasm. Its pathogenesis is discussed, as are the characteristic x-ray features that enable an accurate diagnosis. ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2011/474678
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:The authors have previously reported an increased prevalence of asthma in Estevan, Saskatchewan (21.4%) compared with Swift Current, Saskatchewan (16.2%). OBJECTIVE:To determine the association between asthma and personal and indoor environmental risk factors in these communities. METHODS:A population-base...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2005/942637
更新日期:2005-09-01 00:00:00
abstract::A 40-year-old woman presented with profound weight loss, anemia and multiple pulmonary nodules. Further investigation revealed a hepatic abscess and a pelvic mass associated with an intrauterine device. Cultures of the hepatic abscess and from peripheral blood demonstrated Actinomyces species. The patient underwent an...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2005/461619
更新日期:2005-04-01 00:00:00
abstract:Background:The aim of this study was thus to evaluate the feasibility and safety of taking biopsy specimens by cryoprobe from the parietal pleura during semirigid pleuroscope. Methods:In a single-center, observational, prospective study, patients with exudative pleural effusion (EPE) were evaluated with a semirigid pl...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2018/6746470
更新日期:2018-01-22 00:00:00
abstract::Background. Routine vaccination against Streptococcus pneumoniae is recommended in Canada for infants, the elderly, and individuals with chronic comorbidity. National incidence and burden of all-cause and pneumococcal pneumonia in Canada (excluding Quebec) were assessed. Methods. Incidence, length of stay, and case-fa...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2016/3605834
更新日期:2016-01-01 00:00:00
abstract::In certain parts of the United States and Canada, and northern Ontario in particular, the dimorphic fungus Blastomyces dermatitidis is endemic and can cause infection in exposed individuals. The site of infection is usually pulmonary, causing respiratory and constitutional symptoms, but can also affect other sites in ...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2013/646854
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To assess the length of stay required to initiate long-term invasive ventilation at the authors' institution, which would inform future interventional strategies to streamline the in-hospital stay for these families. METHODS:A retrospective chart review of children initiated on invasive long-term ventilation...
journal_title:Canadian respiratory journal
pub_type: 杂志文章
doi:10.1155/2015/107914
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Noneosinophilic asthma has been regarded as a distinct phenotype characterized by a poor response to inhaled corticosteroids (ICS). OBJECTIVE:To determine whether noneosinophilic, steroid-naive asthmatic subjects show an improvement in asthma control, asthma symptoms and spirometry after four weeks of treat...
journal_title:Canadian respiratory journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2011/108079
更新日期:2011-09-01 00:00:00