Abstract:
:Recent theory has examined the way in which vaccination strategies are expected to influence the evolution of parasite virulence. Most of this work has assumed that vaccination is imposed on a homogeneous host population. However, host populations are typically composed of different types of individuals, with each type responding differently to infection. Moreover, actual interventions often focus treatment on those hosts that are likely to suffer the most ill effects of a particular disease. Here we consider the epidemiological and evolutionary consequences of interventions that focus vaccination on individuals expressing the greatest susceptibility to infection and/or the greatest vulnerability to mortality once infected. Our results indicate that predictions are very sensitive to the nature and degree of heterogeneity in susceptibility and vulnerability. They further suggest that accounting for realistic kinds of heterogeneity when contemplating targeted treatment plans and policies might provide a new tool in the design of more effective virulence management strategies.
journal_name
Mol Ecoljournal_title
Molecular ecologyauthors
Williams PD,Day Tdoi
10.1111/j.1365-294X.2007.03418.xsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
485-99issue
1eissn
0962-1083issn
1365-294Xpii
MEC3418journal_volume
17pub_type
杂志文章abstract::Lady's slipper orchids (Cypripedium spp.) are rare terrestrial plants that grow throughout the temperate Northern Hemisphere. Like all orchids, they require mycorrhizal fungi for germination and seedling nutrition. The nutritional relationships of adult Cypripedium mycorrhizae are unclear; however, Cypripedium distrib...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2005.02424.x
更新日期:2005-02-01 00:00:00
abstract::The Baja California region provides a natural setting for studying the early mechanisms of allopatric speciation in marine systems. Disjunct fish populations from several species that occur in the northern Gulf of California and northern Pacific coast of Baja California, but are absent from its southern shores, were p...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2005.02729.x
更新日期:2005-11-01 00:00:00
abstract::The savannah biome of sub-Saharan Africa harbours the highest diversity of ungulates (hoofed mammals) on Earth. In this review, we compile population genetic data from 19 codistributed ungulate taxa of the savannah biome and find striking concordance in the phylogeographic structuring of species. Data from across taxa...
journal_title:Molecular ecology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-294X.2012.05650.x
更新日期:2012-08-01 00:00:00
abstract::The utility of genetic measures for kinship reconstruction in polysomic species is not well evaluated. We developed a framework to test hypotheses about estimating breeding population size indirectly from collections of outmigrating green sturgeon juveniles. We evaluated a polysomic dataset, in allelic frequency and p...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2010.04533.x
更新日期:2010-03-01 00:00:00
abstract::As populations diverge many processes can shape genomic patterns of differentiation. Regions of high differentiation can arise due to divergent selection acting on selected loci, genetic hitchhiking of nearby loci, or through repeated selection against deleterious alleles (linked background selection); this divergence...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.15480
更新日期:2020-06-01 00:00:00
abstract::We examined the consequences of barriers, stream architecture and putative dispersal capability on levels of genetic differentiation among populations of the freshwater fish Craterocephalus stercusmuscarum. Seven polymorphic allozyme loci and sequences of a 498-bp fragment of the ATPase 6 mitochondrial DNA (mtDNA) gen...
journal_title:Molecular ecology
pub_type: 历史文章,杂志文章
doi:10.1046/j.1365-294x.2000.01054.x
更新日期:2000-11-01 00:00:00
abstract::Microorganisms in the gastrointestinal tract of animals play vital roles in food digestion, homeostasis and immune response regulation. Globally, there are 33,700 fish species, representing almost half of all vertebrate diversity and a wide range of physiologies, ecologies and life histories. To investigate gut microb...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.15699
更新日期:2020-12-01 00:00:00
abstract::Understanding the evolutionary consequences of human-mediated introductions of domesticated strains into the wild and their subsequent admixture with natural populations is of major concern in conservation biology. However, the genomic impacts of stocking from distinct sources (locally derived vs. divergent) on the ge...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.14816
更新日期:2018-09-01 00:00:00
abstract::In lichen symbiosis, fungal and algal partners form close associations, often codispersed by vegetative propagules. Due to the particular interdependence, processes such as colonization, dispersal or genetic drift are expected to result in congruent patterns of genetic structure in the symbionts. To study the populati...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.12051
更新日期:2012-12-01 00:00:00
abstract::Improving resistance durability involves to be able to predict the adaptation speed of pathogen populations. Identifying the genetic bases of pathogen adaptation to plant resistances is a useful step to better understand and anticipate this phenomenon. Globodera pallida is a major pest of potato crop for which a resis...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.14240
更新日期:2017-09-01 00:00:00
abstract::Although resolving phylogenetic relationships and establishing species limits are primary goals of systematics, these tasks remain challenging at both conceptual and analytical levels. Here, we integrated genomic and phenotypic data and employed a comprehensive suite of coalescent-based analyses to develop and evaluat...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.14504
更新日期:2018-03-01 00:00:00
abstract::Comparative phylogeographic studies of animals with low mobility and/or high habitat specificity remain rare, yet such organisms may hold fine-grained palaeoecological signal. Comparisons of multiple, codistributed species can elucidate major historical events. As part of a multitaxon programme, mitochondrial cytochro...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2006.03107.x
更新日期:2006-12-01 00:00:00
abstract::There is ample evidence that organisms adapt to their native environment when gene flow is restricted. However, evolution of plastic responses across discrete environments is less well examined. We studied divergence in means and plasticity across wild and hatchery populations of sea-run brown trout (Salmo trutta) in ...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2012.05590.x
更新日期:2012-06-01 00:00:00
abstract::Rhizosphere microbes affect plant performance, including plant resistance against insect herbivores; yet, a direct comparison of the relative influence of rhizosphere microbes versus plant genetics on herbivory levels and on metabolites related to defence is lacking. In the crucifer Boechera stricta, we tested the eff...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.14989
更新日期:2019-04-01 00:00:00
abstract::Dispersal is a fundamental attribute of species in nature and shapes population dynamics, evolutionary trajectories and genetic variation across spatial and temporal scales. It is increasingly clear that landscape features have large impacts on dispersal patterns. Thus, understanding how individuals and species move t...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2010.04872.x
更新日期:2010-12-01 00:00:00
abstract::Ectomycorrhizal (EcM) fungal communities may be shaped by both deterministic and stochastic processes, potentially influencing ecosystem development and function. We evaluated community assembly processes for EcM fungi of Pseudotsuga menziesii among 12 sites up to 400 km apart in southwest British Columbia (Canada) by...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.13435
更新日期:2015-12-01 00:00:00
abstract::The evolution of incompatibilities between eggs and sperm is thought to play important roles in establishing and maintaining reproductive isolation among species of broadcast-spawning marine invertebrates. However, the effectiveness of gametic isolation in initiating the speciation process and/or in limiting the intro...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2009.04094.x
更新日期:2009-03-01 00:00:00
abstract::Colour vision varies within the family Atelidae (Primates, Platyrrhini), which consists of four genera with the following cladistic relationship: {Alouatta[Ateles (Lagothrix and Brachyteles)]}. Spider monkeys (Ateles) and woolly monkeys (Lagothrix) are characteristic of platyrrhine monkeys in possessing a colour visio...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2005.02822.x
更新日期:2006-02-01 00:00:00
abstract::Recent advances in the application of the polymerase chain reaction make it possible to score individuals at a large number of loci. The RAPD (random amplified polymorphic DNA) method is one such technique that has attracted widespread interest. The analysis of population structure with RAPD data is hampered by the la...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294x.1994.tb00109.x
更新日期:1994-04-01 00:00:00
abstract::Social bees are important insect pollinators of wildflowers and agricultural crops, making their reported declines a global concern. A major factor implicated in these declines is the widespread use of neonicotinoid pesticides. Indeed, recent research has demonstrated that exposure to low doses of these neurotoxic pes...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.15047
更新日期:2019-04-01 00:00:00
abstract::We define a genetic similarity rule that predicts how genetic variation in a dominant plant affects the structure of an arthropod community. This rule applies to hybridizing cottonwood species where plant genetic variation determines plant-animal interactions and structures a dependent community of leaf-modifying arth...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2005.02749.x
更新日期:2006-04-01 00:00:00
abstract::Climatic conditions and landscape features often strongly affect species' local distribution patterns, dispersal, reproduction and survival and may therefore have considerable impacts on species' fine-scale spatial genetic structure (SGS). In this study, we demonstrate the efficacy of combining fine-scale SGS analyses...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2011.05372.x
更新日期:2012-01-01 00:00:00
abstract::In two sister species of leaf beetles with overlapping host associations, Chrysochus auratus and C. cobaltinus, we established diet breadth and food preference of local populations for evaluation together with genetic differentiation between populations. While C. auratus turned out to be monophagous on the same plant ...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1046/j.1365-294x.1999.00693.x
更新日期:1999-08-01 00:00:00
abstract::Phytophthora ramorum (Oomycetes) is an emerging plant pathogen in forests in southwestern Oregon (Curry County). Moreover, since 2003 it has been repeatedly isolated from plants in Oregon nurseries. In this study, we analysed the genetic diversity of the P. ramorum population in Oregon from 2001 to 2004 by using micro...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2007.03343.x
更新日期:2007-07-01 00:00:00
abstract::The concept of kinship permeates many domains of fundamental and applied biology ranging from social evolution to conservation science to quantitative and human genetics. Until recently, pedigrees were the gold standard to infer kinship, but the advent of next-generation sequencing and the availability of dense geneti...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.14833
更新日期:2018-10-01 00:00:00
abstract::Linear and heterogeneous habitat makes headwater stream networks an ideal ecosystem in which to test the influence of environmental factors on spatial genetic patterns of obligatory aquatic species. We investigated fine-scale population structure and influence of stream habitat on individual-level genetic differentiat...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2011.05210.x
更新日期:2011-09-01 00:00:00
abstract::Exceptional ecological niche diversity, clear waters and unique divergent selection pressures have often been invoked to explain high morphological and genetic diversity of taxa within ancient lakes. However, it is possible that in some ancient lake taxa high diversity has arisen because these historically stable envi...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2006.03171.x
更新日期:2007-02-01 00:00:00
abstract::Insect guts are often colonized by multispecies microbial communities that play integral roles in nutrition, digestion and defence. Community composition can differ across host species with increasing dietary and genetic divergence, yet gut microbiota can also vary between conspecific hosts and across an individual's ...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/mec.12607
更新日期:2014-03-01 00:00:00
abstract::The success of non-native species may depend on the genetic resources maintained through the invasion process. The Coqui (Eleutherodactylus coqui), a frog endemic to Puerto Rico, was introduced to Hawaii in the late 1980s via the horticulture trade, and has become an aggressive invader. To explore whether genetic dive...
journal_title:Molecular ecology
pub_type: 杂志文章
doi:10.1111/j.1365-294X.2009.04308.x
更新日期:2009-09-01 00:00:00
abstract::Small and isolated populations face threats from genetic drift and inbreeding. To rescue populations from these threats, conservation biologists can augment gene flow into small populations to increase variation and reduce inbreeding depression. Spectacular success stories include greater prairie chickens in Illinois ...
journal_title:Molecular ecology
pub_type: 评论,杂志文章
doi:10.1111/mec.13220
更新日期:2015-06-01 00:00:00