Antiviral-resistant hepatitis B virus: can we prevent this monster from growing?

abstract：:The treatment of hepatitis C is expensive, difficult and arduous from the patient's perspective. It is similarly difficult for the clinician to decide who and when to treat. If hepatitis C is viewed from the liver's perspective we need only treat those patients who will develop the complications of chronic liver disea...

journal_title：Journal of viral hepatitis

authors： Dillon JF

更新日期：2004-09-01 00:00:00

abstract：:The risk of developing hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is reduced by antiviral therapy. Here, we evaluated the chronological trends in HCC development risk starting in 2007, when entecavir reimbursement was first initiated in South Korea. Treatment-naïve patients with chronic hepatitis B...

journal_title：Journal of viral hepatitis

authors： Kim SU,Chon YE,Seo YS,Lee HW,Lee HA,Kim MN,Min IK,Park JY,Kim DY,Ahn SH,Tak WY,Kim BK,Park SY

更新日期：2020-12-01 00:00:00

abstract：:This open label study was initiated to assess the safety and efficacy of lymphoblastoid interferon-alpha (IFN-alpha) and thymosin alpha 1 (T alpha 1) in the treatment of 11 patients with chronic hepatitis B, who had failed to respond to standard IFN-alpha 2b therapy, and in four interferon naive patients. These fiftee...

journal_title：Journal of viral hepatitis

authors： Rasi G,Mutchnick MG,Di Virgilio D,Sinibaldi-Vallebona P,Pierimarchi P,Colella F,Favalli C,Garaci E

更新日期：1996-07-01 00:00:00

abstract：:Hepatitis Be antigen (HBeAg)-negative chronic hepatitis B (CHB) is associated with hepatitis B virus (HBV) variants harbouring changes in the precore region. Most commonly, a G to A point mutation at nucleotide 1896 (m1896) creates a novel translation stop codon that prevents HBeAg production. In the Mediterranean reg...

journal_title：Journal of viral hepatitis

authors： Laras A,Koskinas J,Avgidis K,Hadziyannis SJ

更新日期：1998-07-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection is associated with many extrahepatic malignancies, but its association with and impact on ovarian cancer has not been examined. We therefore examined the prevalence of HBV infection among women with primary ovarian carcinoma in an endemic area, and whether this impacts the presentatio...

journal_title：Journal of viral hepatitis

authors： Wong L,Cheung TH,Yim SF,Lao TT

更新日期：2020-05-01 00:00:00

abstract：:GB virus type C (GBV-C) is a member of the hepacivirus genus within the Flaviviradae. Persistent GBV-C infection is common in humans, yet it remains unclear if GBV-C causes any disease. Although GBV-C infection has been associated with acute non-A to non-E post-transfusion hepatitis, it does not appear to cause chroni...

journal_title：Journal of viral hepatitis

authors： Xiang J,Daniels KJ,Soll DR,Schmidt WN,Labrecque DR,Stapleton JT

更新日期：1999-07-01 00:00:00

abstract：:Egypt is the country with the largest hepatitis C virus (HCV) epidemic in the world. In 2008, a Demographic Health Survey (DHS) was carried out in Egypt, providing for the first time a unique opportunity for HCV antibody testing on a nationwide representative sample of individuals. Consenting individuals answered a qu...

journal_title：Journal of viral hepatitis

authors： Guerra J,Garenne M,Mohamed MK,Fontanet A

更新日期：2012-08-01 00:00:00

abstract：:Viral load reduction facilitates recovery of antiviral T-cell responses. Dynamic alterations in intrahepatic viraemia clearance and immune cell reactivity during the early phase of nucleoside analogue (NA) therapy and the impact of these changes on HBeAg seroconversion are unknown. Fifteen HBeAg-positive chronic hepat...

journal_title：Journal of viral hepatitis

authors： Zheng Q,Zhu YY,Chen J,Liu YR,You J,Dong J,Zeng DW,Gao LY,Chen LH,Jiang JJ

更新日期：2014-12-01 00:00:00

abstract：:Quantitative serology for hepatitis B surface antigen (HBsAg) is a new candidate marker for prediction of clinical outcome. The aim of this study was to investigate the clinical significance of quantifying HBsAg in patients with hepatitis B virus (HBV) infection. A total of 424 patients who tested positive for HBsAg a...

journal_title：Journal of viral hepatitis

authors： Togo S,Arai M,Tawada A,Chiba T,Kanda T,Fujiwara K,Imazeki F,Yokosuka O

更新日期：2011-10-01 00:00:00

abstract：:In resource-rich countries, the incidence of and mortality from AIDS has fallen dramatically since the introduction of combination antiretroviral therapy. In contrast, developed countries have observed increases in the public health burden associated with the hepatitis C virus (HCV). We compared past and current trend...

journal_title：Journal of viral hepatitis

authors： Palmateer NE,Hutchinson SJ,McLeod A,Codere G,Goldberg DJ

更新日期：2007-12-01 00:00:00

abstract：:The aim of this study was to evaluate the Chiron branched DNA (bDNA) assay for detection of serum hepatitis B virus (HBV) DNA in patients with chronic hepatitis B lacking hepatitis B e antigen (HBeAg) and undergoing interferon (IFN) therapy. Results obtained with the bDNA assay were compared with those obtained using ...

journal_title：Journal of viral hepatitis

authors： Habersetzer F,Zoulim F,Jusot JF,Zhang X,Trabaud MA,Chevallier P,Chevallier M,Ahmed SN,Sepetjan M,Comanor L,Minor J,Trépo C

更新日期：1998-11-01 00:00:00

abstract：:Patients with biopsy-proven chronic hepatitis C, who failed to respond to a previous course of either recombinant (rIFN-alpha) or lymphoblastoid (Ly IFN-alpha) interferon-alpha, were randomized to receive either leucocyte (Le) IFN-alpha (patients) or a second course of the same IFN-alpha (controls), to compare the eff...

journal_title：Journal of viral hepatitis

authors： Gaeta GB,Di Virgilio D,Russo G,Stornaiuolo G,Nicolella U,Colella F,Grimaldi M,Pasquale G,Giusti G

更新日期：1997-05-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV)-infected patients with liver failure have a poor prognosis, and no satisfactory biomarkers are available for diagnosis before the end-stage. We explored serum peptide profiling for diagnosis and prediction of progression to liver failure in HBV-infected patients. Serum samples (164) fro...

journal_title：Journal of viral hepatitis

authors： Han T,Liu H,Yu ZL,Li J,Wang L,Xiao SX,Li Y,Yu ML

更新日期：2010-03-01 00:00:00

abstract：:To determine the relationship between p53 altered expression and p53 mutations in hepatocellular carcinoma (HCC), we analysed p53 protein immunohistochemically and assessed the presence of mutations in exons 4-8 of the p53 gene using SSCP assay in 117 HCCs corresponding to 78 patients. We also determined the relations...

journal_title：Journal of viral hepatitis

authors： Anzola M,Saiz A,Cuevas N,Lopez-Martinez M,Martinez de Pancorbo MA,Burgos JJ

更新日期：2004-11-01 00:00:00

abstract：:Bacteremia has rarely been reported in patients receiving treatment for hepatitis C virus (HCV) infection. We describe the features and investigation of four cases of Staphylococcus aureus bacteremia occurring between 3 November 2004 and 10 January 2005 in patients on therapy for chronic HCV infection. The unusual occ...

journal_title：Journal of viral hepatitis

authors： Webster D,Ahmed R,Tandon P,Chui L,McDonald RR,Obarianyk A,Antonishyn N,Doucette K

更新日期：2007-08-01 00:00:00

abstract：:Seroconversion from hepatitis B surface antigen (HBsAg) to antibodies against HBsAg (anti-HBs) usually indicates resolution of hepatitis B virus (HBV) infection. Here, two HBV-infected patients with seroconversion to anti-HBs were found to be persistently positive for HBeAg and HBV DNA. Immunohistology of liver biopsi...

journal_title：Journal of viral hepatitis

authors： Zhang ZH,Li L,Zhao XP,Glebe D,Bremer CM,Zhang ZM,Tian YJ,Wang BJ,Yang Y,Gerlich W,Roggendorf M,Li X,Lu M,Yang DL

更新日期：2011-06-01 00:00:00

abstract：:Cholangiocarcinoma is the second most common liver cancer in the world. The aetiology of the disease is diverse incorporating a variety of conditions leading to biliary stasis, biliary and liver inflammation, but a large number of cases still occur in the absence of established risk factors. Its incidence and mortalit...

journal_title：Journal of viral hepatitis

authors： Ralphs S,Khan SA

更新日期：2013-05-01 00:00:00

abstract：:To assess the prevalence of hepatitis delta virus (H delta V) in northern India, 204 adult patients with acute and chronic liver disease who were positive for hepatitis B virus (HBV) markers were screened for anti-H delta V antibody by enzyme-linked immunosorbent assay (ELISA). Anti-H delta V antibodies were positive ...

journal_title：Journal of viral hepatitis

authors： Singh V,Goenka MK,Bhasin DK,Kochhar R,Singh K

更新日期：1995-01-01 00:00:00

abstract：:Candidate blood donors in Ghana are frequent carriers of hepatitis B virus (HBV). A comparative study of 117 donor samples including 46 with alanine aminotransferase (ALT) > or = 60 IU/L and 71 with < or =40 IU/L level was undertaken. S and the basic core promoter-precore regions (BCP/PC) sequencing was used to identi...

journal_title：Journal of viral hepatitis

authors： Candotti D,Opare-Sem O,Rezvan H,Sarkodie F,Allain JP

更新日期：2006-11-01 00:00:00

abstract：:Approximately 30% of patients with chronic HCV infection have persistently normal ALT levels. Although formerly referred to as 'healthy' or 'asymptomatic' HCV carriers, and thus historically excluded from antiviral treatment, it has now become clear that the majority of these patients have some degree of histological ...

journal_title：Journal of viral hepatitis

authors： Puoti C,Guarisco R,Spilabotti L,Bellis L,Mitidieri Costanza O,Dell' Unto O,Elmo MG

更新日期：2012-04-01 00:00:00

abstract：:In vitro cell culture experiments and animal models have demonstrated that hepatitis delta virus (HDV) can theoretically propagate being enveloped by human pathogenic viruses other than hepatitis B virus (HBV), namely hepatitis C virus (HCV) and dengue virus. However, the clinical relevance of these findings and wheth...

journal_title：Journal of viral hepatitis

authors： Pflüger LS,Schulze Zur Wiesch J,Polywka S,Lütgehetmann M

更新日期：2021-01-01 00:00:00

abstract：:The incidence of, and risk factors for, acute hepatitis A (AHA) were assessed by using data collected from the Italian surveillance system of acute viral hepatitis (SEIEVA). To this end, a case-control study within a population-based surveillance for acute viral hepatitis was performed. AHA incidence has been estimate...

journal_title：Journal of viral hepatitis

authors： Tosti ME,Spada E,Romanò L,Zanetti A,Mele A,SEIEVA collaborating group.

更新日期：2008-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is associated with insulin resistance (IR), although mechanisms leading to IR in these patients are not completely understood. The aim of this study was to evaluate the association of interleukin 28B (IL28B) and interleukin 28 receptor alpha (IL28RA) polymorphisms with IR among human ...

journal_title：Journal of viral hepatitis

authors： Jiménez-Sousa MA,Berenguer J,Fernández-Rodríguez A,Micheloud D,Guzmán-Fulgencio M,Miralles P,Pineda-Tenor D,García-Álvarez M,López JC,Aldámiz-Echevarria T,Carrero A,Resino S

更新日期：2014-03-01 00:00:00

abstract：:Hepatitis C (HCV) infection can cause cirrhosis, liver cancer and death in the absence of treatment. Many people living in the UK but born overseas are believed to be infected with HCV although many are unlikely to know they are infected. The aim of this study is to assess the potential for a case-finding approach to ...

journal_title：Journal of viral hepatitis

authors： Miners AH,Martin NK,Ghosh A,Hickman M,Vickerman P

更新日期：2014-01-01 00:00:00

abstract：:Peginterferon alpha-2a (40 kDa) plus ribavirin is effective at achieving sustained viral response compared with no treatment in patients with chronic hepatitis C (CHC) and persistently normal aminotransferase levels (PNALT). The cost-effectiveness of treating CHC in the setting of PNALT has not been assessed. Disease ...

journal_title：Journal of viral hepatitis

authors： Hornberger J,Farci P,Prati D,Zeuzem S,Green J,Patel KK

更新日期：2006-06-01 00:00:00

abstract：:Hepatitis C virus (HCV) is commonly transmitted by intravenous drug use (IDU) but drug users are under represented in many treatment cohorts, this is because of the assumption of lowered treatment success. We assessed HCV treatment outcomes in active intravenous drug users and patients on opiate substitution therapy. ...

journal_title：Journal of viral hepatitis

authors： Jafferbhoy H,Miller MH,Dunbar JK,Tait J,McLeod S,Dillon JF

更新日期：2012-02-01 00:00:00

abstract：:In rare cases, individuals with a history of long-term injecting drug use remain seronegative and aviraemic, despite prolonged and likely repeated exposure to Hepatitis C virus (HCV) through high-risk behaviour. We describe anti-HCV Envelope (E) antibody responses in a prospective cohort of carefully defined highly ex...

journal_title：Journal of viral hepatitis

authors： Mina M,Underwood A,Eltahla A,Wu BR,Walker MR,Bull RA,Lloyd AR

更新日期：2020-10-01 00:00:00

abstract：:Hepatitis E virus (HEV) is a major cause of acute hepatitis in many developing countries. Based on data from nonendemic regions, an animal reservoir of HEV has been proposed; however, data from HEV-endemic regions are limited. We tested sera from 200 pigs, 98 chickens, 86 goats, 58 sheep and 30 buffaloes for anti-HEV ...

journal_title：Journal of viral hepatitis

authors： Shukla P,Chauhan UK,Naik S,Anderson D,Aggarwal R

更新日期：2007-05-01 00:00:00

abstract：:Through molecular virological testing it is now clear that HCV reinfection of the allograft is virtually universal in liver transplant recipients. Although histopathological recurrence of hepatitis C occurs in the majority of patients, it is absent in a substantial minority. To date, no prognostic factors, other than ...

journal_title：Journal of viral hepatitis

authors： Vierling JM,Villamil FG,Rojter SE,Camacho KB,Goldman DE

更新日期：1997-01-01 00:00:00

abstract：:Mixed cryoglobulinaemia, when not secondary to other well-defined immunological disorders, is commonly associated with hepatitis C virus (HCV) infection. However, a minority of cases lack evidence of HCV infection and are, therefore, defined as 'true essential' mixed cryoglobulinaemias. We thoroughly investigated thre...

journal_title：Journal of viral hepatitis

authors： Casato M,Lilli D,Donato G,Granata M,Conti V,Del Giudice G,Rivanera D,Scagnolari C,Antonelli G,Fiorilli M

更新日期：2003-11-01 00:00:00