Assessing the cost-effectiveness of finding cases of hepatitis C infection in UK migrant populations and the value of further research.

abstract：:The effect of direct-acting antiviral (DAA) therapy on extracellular matrix (ECM) turnover, a prominent feature of chronic hepatitis C (CHC), is unknown. ECM protein degradation and formation generate fragments reflecting the tissue turnover balance when quantified in the blood. PRO-C3 and PRO-C4 reflect type III and ...

journal_title：Journal of viral hepatitis

authors： Laursen TL,Villesen IF,Leeming DJ,Karsdal MA,Sølund C,Tarp B,Kristensen LH,Holmboe CH,Leutscher P,Laursen AL,Gudmann NS,Grønbaek H

更新日期：2021-02-01 00:00:00

abstract：:In rare cases, individuals with a history of long-term injecting drug use remain seronegative and aviraemic, despite prolonged and likely repeated exposure to Hepatitis C virus (HCV) through high-risk behaviour. We describe anti-HCV Envelope (E) antibody responses in a prospective cohort of carefully defined highly ex...

journal_title：Journal of viral hepatitis

authors： Mina M,Underwood A,Eltahla A,Wu BR,Walker MR,Bull RA,Lloyd AR

更新日期：2020-10-01 00:00:00

abstract：:Our study was conducted to further investigate the single-dose approach of hepatitis A vaccination, while providing supportive data on the flexibility of booster administration. Participants received at least one dose of Avaxim 80U Pediatric at 11-23 months of age, and they will be followed for 10 years. We report her...

journal_title：Journal of viral hepatitis

authors： Espul C,Benedetti L,Linares M,Cuello H,Rasuli A

更新日期：2015-04-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is currently the most important cause of chronic viral hepatitis in the world and one of the most frequent indications for liver transplantation. HCV uses different strategies to evade the innate and adaptive immune response, and this evasion plays a key role in determining viral pers...

journal_title：Journal of viral hepatitis

authors： Fernández-Ponce C,Dominguez-Villar M,Muñoz-Miranda JP,Arbulo-Echevarria MM,Litrán R,Aguado E,García-Cozar F

更新日期：2017-05-01 00:00:00

abstract：:GB virus type C (GBV-C) is a member of the hepacivirus genus within the Flaviviradae. Persistent GBV-C infection is common in humans, yet it remains unclear if GBV-C causes any disease. Although GBV-C infection has been associated with acute non-A to non-E post-transfusion hepatitis, it does not appear to cause chroni...

journal_title：Journal of viral hepatitis

authors： Xiang J,Daniels KJ,Soll DR,Schmidt WN,Labrecque DR,Stapleton JT

更新日期：1999-07-01 00:00:00

abstract：SUMMARY:Both absolute viral load and log decline in viral load from baseline were found clinically useful in predicting sustained virological response and lack of sustained virological response (non-sustained virological response, NSVR) to treatment. We assessed the clinical utility of hepatitis C virus (HCV) RNA quant...

journal_title：Journal of viral hepatitis

authors： Terrault NA,Pawlotsky JM,McHutchison J,Anderson F,Krajden M,Gordon S,Zitron I,Perrillo R,Gish R,Holodniy M,Friesenhahn M

更新日期：2005-09-01 00:00:00

abstract：SUMMARY:Treatment of hepatitis C virus (HCV) infection with interferon (IFN)-alpha, as monotherapy or in combination with ribavirin, is associated with significant side-effects including weight loss. The aim of our study was to describe the evolution of body weight during combination antiviral treatment and to examine ...

journal_title：Journal of viral hepatitis

authors： Seyam MS,Freshwater DA,O'Donnell K,Mutimer DJ

更新日期：2005-09-01 00:00:00

abstract：:This study assessed the association of HIV RNA with indirect markers of liver injury including FIB-4 index, liver enzymes and platelet counts in a high-risk Hispanic population. The data were derived from a prospective study that included 138 HIV/hepatitis C (HCV)-coinfected and 68 HIV-infected participants without he...

journal_title：Journal of viral hepatitis

authors： Forrester JE,Rhee MS,McGovern BH,Sterling RK,Knox TA,Terrin N

更新日期：2012-02-01 00:00:00

abstract：:The incidence of, and risk factors for, acute hepatitis A (AHA) were assessed by using data collected from the Italian surveillance system of acute viral hepatitis (SEIEVA). To this end, a case-control study within a population-based surveillance for acute viral hepatitis was performed. AHA incidence has been estimate...

journal_title：Journal of viral hepatitis

authors： Tosti ME,Spada E,Romanò L,Zanetti A,Mele A,SEIEVA collaborating group.

更新日期：2008-10-01 00:00:00

abstract：:In resource-rich countries, the incidence of and mortality from AIDS has fallen dramatically since the introduction of combination antiretroviral therapy. In contrast, developed countries have observed increases in the public health burden associated with the hepatitis C virus (HCV). We compared past and current trend...

journal_title：Journal of viral hepatitis

authors： Palmateer NE,Hutchinson SJ,McLeod A,Codere G,Goldberg DJ

更新日期：2007-12-01 00:00:00

abstract：:The limitations of liver biopsy have led to the development of indirect noninvasive models for liver fibrosis assessment. We aimed to evaluate and compare the performance of 30 noninvasive models to predict fibrosis stage in treatment-naïve and treated chronic hepatitis B (CHB) patients. A total of 576 Chinese treatme...

journal_title：Journal of viral hepatitis

authors： Dong XQ,Wu Z,Zhao H,Wang GQ,China HepB-Related Fibrosis Assessment Research Group.

更新日期：2019-02-01 00:00:00

abstract：:The risk of developing hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is reduced by antiviral therapy. Here, we evaluated the chronological trends in HCC development risk starting in 2007, when entecavir reimbursement was first initiated in South Korea. Treatment-naïve patients with chronic hepatitis B...

journal_title：Journal of viral hepatitis

authors： Kim SU,Chon YE,Seo YS,Lee HW,Lee HA,Kim MN,Min IK,Park JY,Kim DY,Ahn SH,Tak WY,Kim BK,Park SY

更新日期：2020-12-01 00:00:00

abstract：:The efficacy of monotherapy with interferon (IFN) (conventional or pegylated IFN) in dialysis patients with chronic hepatitis C remains unclear, although a number of clinical trials have been published addressing this issue. The aim of the study was to evaluate the efficacy and safety of monotherapy by conventional or...

journal_title：Journal of viral hepatitis

authors： Fabrizi F,Dixit V,Messa P,Martin P

更新日期：2008-02-01 00:00:00

abstract：SUMMARY:Noninvasive markers that accurately follow changes in fibrosis may provide alternatives to liver biopsy for assessment of histological endpoints of antiviral therapy in chronic hepatitis C (CHC). This study compared two commercially available serum marker panels (HCV FibroSURE and FIBROSpect II) during interfer...

journal_title：Journal of viral hepatitis

authors： Patel K,Benhamou Y,Yoshida EM,Kaita KD,Zeuzem S,Torbenson M,Pulkstenis E,Subramanian GM,McHutchison JG

更新日期：2009-03-01 00:00:00

abstract：:Patients with biopsy-proven chronic hepatitis C, who failed to respond to a previous course of either recombinant (rIFN-alpha) or lymphoblastoid (Ly IFN-alpha) interferon-alpha, were randomized to receive either leucocyte (Le) IFN-alpha (patients) or a second course of the same IFN-alpha (controls), to compare the eff...

journal_title：Journal of viral hepatitis

authors： Gaeta GB,Di Virgilio D,Russo G,Stornaiuolo G,Nicolella U,Colella F,Grimaldi M,Pasquale G,Giusti G

更新日期：1997-05-01 00:00:00

abstract：:The focus of this study was to evaluate the safety and efficacy of sequential peginterferon α-2a (Pegasys) therapy for chronic hepatitis B with acute exacerbation [ALT > 10 × upper limit of normal (ULN), bilirubin <2.0 mg/dL]. Four groups of patients categorized by HBeAg status and treatment regimens were studied sinc...

journal_title：Journal of viral hepatitis

authors： Chen CC,Wang PC,Chang HW,Chen CF

更新日期：2012-03-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection and its sequelae remain a major health problem for Taiwan. The national hepatitis B (HB) vaccination programme was first launched in 1984 to combat the spread of this infection. This study examined the status of HBV infection amongst students at a Taiwanese university in 2005, 18 year...

journal_title：Journal of viral hepatitis

authors： Su FH,Chen JD,Cheng SH,Sung KY,Jeng JJ,Chu FY

更新日期：2008-01-01 00:00:00

abstract：:Summary.  Directly acting antiviral (DAA) agents are currently revolutionizing the treatment of chronic hepatitis C infection. The first generation of these agents have significant limitations including cost issues that are of particular concern in the developing world and a lack of efficacy in genotype 3 patients. Bo...

journal_title：Journal of viral hepatitis

authors： Ahmed F

更新日期：2013-05-01 00:00:00

abstract：:Serological and biochemical studies indicate that acute HBV infection is resolved in the context of an efficient cell-mediated immune (CMI) response, whereas, chronic infection is characterized by weak to undetectable CMI responses and relatively efficient humoral immunity. Because humoral immunity and CMI are regulat...

journal_title：Journal of viral hepatitis

authors： Milich DR

更新日期：1997-01-01 00:00:00

abstract：:A randomized trial was conducted to assess the efficacy of interferon-alpha (IFN) daily in combination with ribavirin in 301 naïve patients with chronic hepatitis C (CHC). Patients were randomized to receive ribavirin 1.2 g daily (QD) for 48 weeks with either IFN 5 MU (thrice weekly) TIW for 8 weeks followed by IFN 3 ...

journal_title：Journal of viral hepatitis

authors： Tassopoulos NC,Ketikoglou I,Tsantoulas D,Raptopoulou M,Hatzis G,Vafiadis I,Sidiropoulos L,Kanatakis S,Anagnostopoulos G,Sypsa V,Hatzakis A,Hellenic Viral Hepatitis Research Network.

更新日期：2003-09-01 00:00:00

abstract：:Although long-term antiviral treatment with nucleos(t)ide analogs (NAs) can lead to histological improvement in patients with chronic hepatitis B (CHB), a substantial proportion of patients still fail to achieve regression of fibrosis. Here, we investigated whether peginterferon alpha (Peg-IFNα） add-on therapy had ben...

journal_title：Journal of viral hepatitis

authors： Li G,Zhang Q,Yu Y,Qiu C,Zhang H,Zhang M,Song Z,Yang Y,Hong J,Lu J,Li N,Tang Q,Xu L,Wang X,Zhang W,Chen Z

更新日期：2019-07-01 00:00:00

abstract：:The ECHO model was developed to expand access to medical care for populations with HCV infection in underserved areas. We aimed to compare HCV treatment outcomes in community-based clinics with the Austral University Hospital (AUH) and to assess improvement in physician knowledge and skills. In October 2015, we establ...

journal_title：Journal of viral hepatitis

authors： Mendizabal M,Ridruejo E,Ceballos S,Sixto M,Billordo A,Gadea C,Mengarelli S,Alonso C,Palazzo A,De María L,Bruno A,Perez D,Piñero F,Deltrozzo V,Mendoza C,Figueroa S,Manero E,Villa M,Barreyro F,Moreno V,Vilar J,Mur

更新日期：2019-11-01 00:00:00

abstract：:The Fas / Fas-ligand (FasL) system is an important death signal pathway in the liver. An enhanced local inflammatory response prompted by FasL expression, which contributes to neutrophil recruitment and interleukin-1 beta (IL-1beta) release, seems to be crucial to chronic liver damage, persistence of viral infections,...

journal_title：Journal of viral hepatitis

authors： Bortolami M,Kotsafti A,Cardin R,Farinati F

更新日期：2008-07-01 00:00:00

abstract：:Treatment of chronic hepatitis B has been greatly improved by the use of lamivudine, but mutations occur in the polymerase region of hepatitis B virus (HBV) and lamivudine-resistant mutants frequently develop. The emergence of lamivudine-resistant strains of HBV is a problem for treating chronic hepatitis B using lami...

journal_title：Journal of viral hepatitis

authors： Natsuizaka M,Hige S,Ono Y,Ogawa K,Nakanishi M,Chuma M,Yoshida S,Asaka M

更新日期：2005-03-01 00:00:00

abstract：:Favourable efficacy and safety profiles for simeprevir in combination with pegylated interferon alpha (PEG-IFNα) and ribavirin (triple therapy) have been shown in clinical trials. This study was carried out to evaluate the effectiveness of simeprevir-based triple therapy for patients with prior telaprevir treatment fa...

journal_title：Journal of viral hepatitis

authors： Ogawa E,Furusyo N,Dohmen K,Kajiwara E,Kawano A,Nomura H,Takahashi K,Satoh T,Azuma K,Nakamuta M,Koyanagi T,Kotoh K,Shimoda S,Hayashi J,Kyushu University Liver Disease Study (KULDS) Group.

更新日期：2015-12-01 00:00:00

abstract：:Mixed cryoglobulinaemia, when not secondary to other well-defined immunological disorders, is commonly associated with hepatitis C virus (HCV) infection. However, a minority of cases lack evidence of HCV infection and are, therefore, defined as 'true essential' mixed cryoglobulinaemias. We thoroughly investigated thre...

journal_title：Journal of viral hepatitis

authors： Casato M,Lilli D,Donato G,Granata M,Conti V,Del Giudice G,Rivanera D,Scagnolari C,Antonelli G,Fiorilli M

更新日期：2003-11-01 00:00:00

abstract：:To evaluate the prevalence and indicators of hepatitis C virus (HCV) infection in Houston and determine the effectiveness of targeted HCV screening in sexually transmitted disease (STD) clinics. We performed a cross-sectional survey in low-risk and high-risk groups in Houston. This included a blinded survey of HCV con...

journal_title：Journal of viral hepatitis

authors： D'Souza G,Arafat R,Hwang L,Cunningham C,Shah S,Reynolds K

更新日期：2003-03-01 00:00:00

abstract：:Circulating microRNAs (miRNA) have been intensely investigated as biomarkers in disease and therapy. Several studies have identified miR-122 as an important regulator of HCV replication. The effect of new therapies that directly target the HCV replication life cycle on circulating microRNA levels has not been elucidat...

journal_title：Journal of viral hepatitis

authors： Waring JF,Dumas EO,Abel S,Coakley E,Cohen DE,Davis JW,Podsadecki T,Dutta S

更新日期：2016-02-01 00:00:00

abstract：:The aims of the present study were to assess initial virological response (IVR) to adefovir (ADV) treatment for chronic hepatitis B, to identify patients with suboptimal response and to determine the incidence of ADV-resistant mutants. All patients treated with ADV for at least 12 months were evaluated for virological...

journal_title：Journal of viral hepatitis

authors： Gallego A,Sheldon J,García-Samaniego J,Margall N,Romero M,Hornillos P,Soriano V,Enrĺquez J

更新日期：2008-05-01 00:00:00

abstract：:Chronic non-A, non-B hepatitis (NANBH) is a common and often progressive liver disease. Based on current serological tests, hepatitis C virus (HCV) infection is responsible for most cases. Interferon-alpha (IFN) treatment at a dose of 3 x 10(6) units given three times per week for 24 weeks has been shown to be effecti...

journal_title：Journal of viral hepatitis

authors： Davis GL,Lindsay K,Albrecht J,Bodenheimer HC Jr,Balart LA,Perrillo RP,Dienstag JL,Tamburro C,Schiff ER,Carey W

更新日期：1994-01-01 00:00:00