FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin.

abstract：:During pregnancy the plasma concentration of two different inhibitors of plasminogen activators (PAIs) increases. The only one found in the plasma of nonpregnant women (PAI1) is immunologically related to a PAI of endothelial cells; its plasma activity, as deduced from the inhibition of single-chain tissue-type plasmi...

journal_title：Blood

authors： Kruithof EK,Tran-Thang C,Gudinchet A,Hauert J,Nicoloso G,Genton C,Welti H,Bachmann F

更新日期：1987-02-01 00:00:00

abstract：:We prospectively evaluated 169 patients with a number of screening studies performed between 71 to 121 days after allogeneic marrow transplantation to detect the development of chronic graft-versus-host disease (GVHD). Group 1 patients (n = 78) were asymptomatic and had normal physical examinations at the time of scre...

journal_title：Blood

authors： Loughran TP Jr,Sullivan K,Morton T,Beckham C,Schubert M,Witherspoon R,Sale G,Sanders J,Fisher L,Shulman H

更新日期：1990-07-01 00:00:00

abstract：:The most frequently recurring translocations in mucosa-associated lymphoid tissue (MALT) B-cell non-Hodgkin lymphoma, t(11;18)(q21;q21) and t(14;18)(q32; q21), lead to formation of an API2-MALT1 fusion or IgH-mediated MALT1 overexpression. Various approaches have implicated these proteins in nuclear factor kappaB (NF-...

journal_title：Blood

authors： Ho L,Davis RE,Conne B,Chappuis R,Berczy M,Mhawech P,Staudt LM,Schwaller J

更新日期：2005-04-01 00:00:00

abstract：:Agammaglobulinemia is the most profound primary antibody deficiency that can occur due to an early termination of B-cell development. We here investigated 3 novel patients, including the first known adult, from unrelated families with agammaglobulinemia, recurrent infections, and hypertrophic cardiomyopathy (HCM). Two...

journal_title：Blood

authors： Saettini F,Poli C,Vengoechea J,Bonanomi S,Orellana JC,Fazio G,Rodriguez FH,Noguera LP,Booth CA,Jarur-Chamy V,Shams M,Iascone M,Vukic M,Gasperini S,Quadri M,Barroeta Seijas AB,Rivers E,Mauri M,Badolato R,Cazzaniga G

更新日期：2020-09-09 00:00:00

abstract：:Twenty-eight patients with multiple myeloma responding to prior melphalan-prednisone combinations, but without additional chemotherapy, were followed until relapse. Patients receiving no further treatment had a median survival time similar to that of those receiving indefinite courses of melphalan-prednisone or carmus...

journal_title：Blood

authors： Alexanian R,Gehan E,Haut A,Saiki J,Weick J

更新日期：1978-06-01 00:00:00

abstract：:Adoptive T-cell therapy in cancer or chronic viral infections is often impeded by the development of functional impairment of the transferred cells. To overcome this therapeutic limitation we combined adoptive transfer of naive, virus-specific CD8+ T cells with immunostimulative CpG oligodeoxynucleotides (ODNs) in mic...

journal_title：Blood

authors： Kraft AR,Krux F,Schimmer S,Ohlen C,Greenberg PD,Dittmer U

更新日期：2007-04-01 00:00:00

abstract：:The most common forms of hereditary persistence of fetal hemoglobin (HPFH) involve large deletions that remove the adult delta and beta genes but leave the paired fetal genes (G gamma and A gamma) intact. The size of these deletions has previously eluded exact definition. Using pulsed-field gel electrophoresis and the...

journal_title：Blood

authors： Collins FS,Cole JL,Lockwood WK,Iannuzzi MC

更新日期：1987-12-01 00:00:00

abstract：:Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific immunoglobulin G (IgG...

journal_title：Blood

authors： Jandus P,Boligan KF,Smith DF,de Graauw E,Grimbacher B,Jandus C,Abdelhafez MM,Despont A,Bovin N,Simon D,Rieben R,Simon HU,Cummings RD,von Gunten S

更新日期：2019-11-28 00:00:00

abstract：:The mi locus of mice encodes a member of the basic-helix-loop-helix-leucine zipper (bHLH-Zip) protein family of transcription factors (hereafter called MITF). Cultured mast cells of mi/mi genotype (mi/mi CMCs) did not normally respond to stem cell factor (SCF), a ligand for the c-kit receptor tyrosine kinase. The poor...

journal_title：Blood

authors： Tsujimura T,Morii E,Nozaki M,Hashimoto K,Moriyama Y,Takebayashi K,Kondo T,Kanakura Y,Kitamura Y

更新日期：1996-08-15 00:00:00

abstract：:Erythropoietin (EPO) is the hormone necessary for development of erythrocytes from immature erythroid cells. EPO activates Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family in the EPO-dependent murine erythroid HCD57 cells. Therefore, we tested if JNK activity supported prolif...

journal_title：Blood

authors： Jacobs-Helber SM,Sawyer ST

更新日期：2004-08-01 00:00:00

abstract：:The combined blockade of the IL-6R/STAT3 and the MAPK signaling pathways has been shown to inhibit bone marrow microenvironment (BMM)-mediated survival of multiple myeloma (MM) cells. Here, we identify the molecular chaperones heat shock proteins (Hsp) 90alpha and beta as target genes of both pathways. The siRNA-media...

journal_title：Blood

authors： Chatterjee M,Jain S,Stühmer T,Andrulis M,Ungethüm U,Kuban RJ,Lorentz H,Bommert K,Topp M,Krämer D,Müller-Hermelink HK,Einsele H,Greiner A,Bargou RC

更新日期：2007-01-15 00:00:00

abstract：:Leukemia inhibitory factor (LIF)/differentiation-inhibiting activity (DIA)/human interleukin for DA cells (HILDA) is a cytokine with biologic activities involving a variety of different types of target cells. Here we have tested LIF/DIA for possible effects on the growth and differentiation of normal human hematopoiet...

journal_title：Blood

authors： Leary AG,Wong GG,Clark SC,Smith AG,Ogawa M

更新日期：1990-05-15 00:00:00

abstract：:The platelet release reaction plays a critical role in thrombosis and contributes to the events that follow hemostasis. Previous studies have shown that platelet secretion is mediated by Soluble NSF Attachment Protein Receptor (SNARE) proteins from granule and plasma membranes. The SNAREs form transmembrane complexes ...

journal_title：Blood

authors： Ye S,Karim ZA,Al Hawas R,Pessin JE,Filipovich AH,Whiteheart SW

更新日期：2012-09-20 00:00:00

abstract：:In B cells, expression of CIITA and resulting major histocompatibility complex II (MHCII) is mediated exclusively by promoter III (CIITA-PIII) activation. Recent studies have established that CIITA-PIII also participates in the expression of CIITA in activated human T cells, dendritic cells, and monocytes. In this stu...

journal_title：Blood

authors： van der Stoep N,Quinten E,Marcondes Rezende M,van den Elsen PJ

更新日期：2004-11-01 00:00:00

abstract：:Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes. To better define the underlying molecular mechanisms driving the erythroid phen...

journal_title：Blood

authors： Fagnan A,Bagger FO,Piqué-Borràs MR,Ignacimouttou C,Caulier A,Lopez CK,Robert E,Uzan B,Gelsi-Boyer V,Aid Z,Thirant C,Moll U,Tauchmann S,Kurtovic-Kozaric A,Maciejewski J,Dierks C,Spinelli O,Salmoiraghi S,Pabst T,Shimo

更新日期：2020-08-06 00:00:00

abstract：:Despite the established utility of serum transferrin receptor (sTfR), serum ferritin, and the sTfR/log ferritin ratio (TfR-F Index) in the diagnosis of iron deficiency (ID) anemia, the numeric values of these parameters, which are indicative of subclinical ID, remain to be clearly defined. In this study, 65 apparently...

journal_title：Blood

authors： Suominen P,Punnonen K,Rajamäki A,Irjala K

更新日期：1998-10-15 00:00:00

abstract：:Vorinostat (suberoylanilide hydroxamic acid, SAHA) is a histone deacetylase inhibitor active clinically in cutaneous T-cell lymphoma and preclinically in leukemia. A phase 1 study was conducted to evaluate the safety and activity of oral vorinostat 100 to 300 mg twice or thrice daily for 14 days followed by 1-week res...

journal_title：Blood

authors： Garcia-Manero G,Yang H,Bueso-Ramos C,Ferrajoli A,Cortes J,Wierda WG,Faderl S,Koller C,Morris G,Rosner G,Loboda A,Fantin VR,Randolph SS,Hardwick JS,Reilly JF,Chen C,Ricker JL,Secrist JP,Richon VM,Frankel SR,Kantarj

更新日期：2008-02-01 00:00:00

abstract：:Chimeric antigen receptor (CAR) T cells have radically improved the treatment of B cell-derived malignancies by targeting CD19. The success has not yet expanded to treat acute myeloid leukemia (AML). We developed a Sequentially Tumor-Selected Antibody and Antigen Retrieval (STAR) system to rapidly isolate multiple nan...

journal_title：Blood

authors： He X,Feng Z,Ma J,Ling S,Cao Y,Gurung B,Wu Y,Katona BW,O'Dwyer KP,Siegel DL,June CH,Hua X

更新日期：2020-03-05 00:00:00

abstract：:Graft-versus-host disease (GVHD) is the main complication of allogeneic stem cell transplantation. However, diagnosis of GVHD and evaluation of response to immunosuppressive treatment is sometimes difficult. Since apoptosis is the histopathologic hallmark in GVHD, we investigated whether active GVHD-induced target org...

journal_title：Blood

authors： Luft T,Conzelmann M,Benner A,Rieger M,Hess M,Strohhaecker U,Görner M,Hegenbart U,Ho AD,Dreger P

更新日期：2007-12-15 00:00:00

abstract：:The congenital sideroblastic anemias (CSAs) are relatively uncommon diseases characterized by defects in mitochondrial heme synthesis, iron-sulfur (Fe-S) cluster biogenesis, or protein synthesis. Here we demonstrate that mutations in HSPA9, a mitochondrial HSP70 homolog located in the chromosome 5q deletion syndrome 5...

journal_title：Blood

authors： Schmitz-Abe K,Ciesielski SJ,Schmidt PJ,Campagna DR,Rahimov F,Schilke BA,Cuijpers M,Rieneck K,Lausen B,Linenberger ML,Sendamarai AK,Guo C,Hofmann I,Newburger PE,Matthews D,Shimamura A,Snijders PJ,Towne MC,Niemeyer CM,

更新日期：2015-12-17 00:00:00

abstract：:Although the expression of Pitx2, a bicoid family homeodomain transcription factor, is highly regulated during hematopoiesis, its function during this process was not documented; we thus studied hematopoiesis in Pitx2-null mice. We found that Pitx2(-/-) embryos display hypoplastic livers with reduced numbers of hemato...

journal_title：Blood

authors： Kieusseian A,Chagraoui J,Kerdudo C,Mangeot PE,Gage PJ,Navarro N,Izac B,Uzan G,Forget BG,Dubart-Kupperschmitt A

更新日期：2006-01-15 00:00:00

abstract：:Salivary gland mucosa-associated lymphoid tissue (MALT) type lymphomas are typically indolent B-cell neoplasms that are often associated with Sjogren's syndrome. To better define the cell of origin and evaluate whether antigen receptor stimulation may be playing a role in tumor growth, the Ig heavy and light chain var...

journal_title：Blood

authors： Bahler DW,Miklos JA,Swerdlow SH

更新日期：1997-05-01 00:00:00

abstract：:Chronic myelocytic leukemia (CML) is a common neoplasm of hematopoietic pluripotent stem cells. Although the evolution from chronic phase to blast crisis (BC) in CML patients is an inevitable clinical feature, little is understood about the mechanisms responsible for the transformation. We have previously performed al...

journal_title：Blood

authors： Mori N,Morosetti R,Spira S,Lee S,Ben-Yehuda D,Schiller G,Landolfi R,Mizoguchi H,Koeffler HP

更新日期：1998-11-01 00:00:00

abstract：:The human interleukin-3 receptor (IL-3R) is expressed on myeloid, lymphoid, and vascular endothelial cells, where it transduces IL-3-dependent signals leading to cell activation. Although IL-3R activation may play a role in hematopoiesis and immunity, its aberrant expression or excessive stimulation may contribute to ...

journal_title：Blood

authors： Sun Q,Woodcock JM,Rapoport A,Stomski FC,Korpelainen EI,Bagley CJ,Goodall GJ,Smith WB,Gamble JR,Vadas MA,Lopez AF

更新日期：1996-01-01 00:00:00

abstract：:The PIT1/SLC20A1 protein, a well-described sodium/phosphate cotransporter and retrovirus receptor, has been identified recently as a modular of proliferation and apoptosis in vitro. The targeted deletion of the PIT1 gene in mice revealed a lethal phenotype due to severe anemia attributed to defects in liver developmen...

journal_title：Blood

authors： Forand A,Beck L,Leroy C,Rousseau A,Boitez V,Cohen I,Courtois G,Hermine O,Friedlander G

更新日期：2013-01-24 00:00:00

abstract：:We investigated whether the stem cell that reconstitutes total erythropoiesis of a WBB6F1-W/Wv mouse differentiates into lymphoid lineage. The electrophoretic pattern of hemoglobin was used as a marker of the reconstitution; 3-phosphoglycerate kinase (PGK), an X chromosome-linked enzyme was used as a tool for estimati...

journal_title：Blood

authors： Nakano T,Waki N,Asai H,Kitamura Y

更新日期：1989-04-01 00:00:00

abstract：:Cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) are synthetic ODNs with unmethylated DNA sequences that mimic viral and bacterial DNA and protect against infectious agents and tumor challenge. We show that CpG ODNs markedly accelerated graft-versus-host disease (GVHD) lethality by Toll-like receptor...

journal_title：Blood

authors： Taylor PA,Ehrhardt MJ,Lees CJ,Panoskaltsis-Mortari A,Krieg AM,Sharpe AH,Murphy WJ,Serody JS,Hemmi H,Akira S,Levy RB,Blazar BR

更新日期：2008-10-15 00:00:00

abstract：:The detection of a monoclonal immunoglobulin in serum or urine usually raises concerns about the size of the underlying B-cell-derived clone and possible systemic effects caused by its expansion. However, a small clone can synthesize a very toxic protein, producing devastating systemic damage and protean clinical pres...

journal_title：Blood

authors： Merlini G,Stone MJ

更新日期：2006-10-15 00:00:00

abstract：:Cytogenetics is considered one of the most valuable prognostic determinants in acute myeloid leukemia (AML). However, many studies on which this assertion is based were limited by relatively small sample sizes or varying treatment approach, leading to conflicting data regarding the prognostic implications of specific ...

journal_title：Blood

authors： Grimwade D,Walker H,Oliver F,Wheatley K,Harrison C,Harrison G,Rees J,Hann I,Stevens R,Burnett A,Goldstone A

更新日期：1998-10-01 00:00:00

abstract：:Primary cutaneous lymphomas have been successfully treated with interferons (IFNs), counterbalancing the T-helper 2 (Th2)-skewing state. We undertook a phase 1, open-label, dose-escalating trial of repeated intratumoral administration of TG1042 in patients with advanced primary cutaneous T-cell lymphomas (CTCLs) and m...

journal_title：Blood

authors： Dummer R,Hassel JC,Fellenberg F,Eichmüller S,Maier T,Slos P,Acres B,Bleuzen P,Bataille V,Squiban P,Burg G,Urosevic M

更新日期：2004-09-15 00:00:00