Abstract:
:This study examined the potential for metabolism of select polycyclic aromatic hydrocarbons (PAH) by human enteric microorganisms. Experiments were performed under anaerobic conditions with various combinations of enteric microbial suspensions, PAH concentrations, nutrient mixtures, and time courses. No PAH metabolites were detected upon GC-TOF-MS analysis of samples digested by tetramethylammonium hydroxide thermochemolysis. No mineralization of (14)C-labeled phenanthrene was observed. These results suggest the lack of partial or complete metabolism of PAHs by enteric microorganisms and therefore the absence of major bioactivation pathways that would expose intestinal lining to potentially carcinogenic PAH metabolites.
journal_name
Bull Environ Contam Toxicoljournal_title
Bulletin of environmental contamination and toxicologyauthors
Hurdzan CM,Basta NT,Hatcher PG,Tuovinen OHdoi
10.1007/s00128-007-9247-ysubject
Has Abstractpub_date
2007-11-01 00:00:00pages
533-6issue
5eissn
0007-4861issn
1432-0800journal_volume
79pub_type
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