Abstract:
:The long-term impact of prenatal methylmercury (MeHg) exposure on the stress response during active learning was investigated. Pregnant rats were gavage fed MeHg (8 mg/kg) on gestational day 15. Ninety-day-old rats born to both MeHg- and saline-treated dams were subjected to an active avoidance test. The active avoidance-experienced rats (AAERs) with prenatal exposure to MeHg showed significant impairment in learning ability and exhibited higher levels of corticosterone than the untreated AAERs. The present findings suggest that the abnormal increase in plasma corticosterone levels could contribute to the poor performance of MeHg-treated AAERs in this learning task.
journal_name
Bull Environ Contam Toxicoljournal_title
Bulletin of environmental contamination and toxicologyauthors
Carratù MR,Coluccia A,Modafferi AM,Borracci P,Scaccianoce S,Sakamoto M,Cuomo Vdoi
10.1007/s00128-008-9557-8subject
Has Abstractpub_date
2008-12-01 00:00:00pages
539-42issue
6eissn
0007-4861issn
1432-0800journal_volume
81pub_type
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journal_title:Bulletin of environmental contamination and toxicology
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