Prenatal methylmercury exposure: effects on stress response during active learning.

Abstract:

:The long-term impact of prenatal methylmercury (MeHg) exposure on the stress response during active learning was investigated. Pregnant rats were gavage fed MeHg (8 mg/kg) on gestational day 15. Ninety-day-old rats born to both MeHg- and saline-treated dams were subjected to an active avoidance test. The active avoidance-experienced rats (AAERs) with prenatal exposure to MeHg showed significant impairment in learning ability and exhibited higher levels of corticosterone than the untreated AAERs. The present findings suggest that the abnormal increase in plasma corticosterone levels could contribute to the poor performance of MeHg-treated AAERs in this learning task.

authors

Carratù MR,Coluccia A,Modafferi AM,Borracci P,Scaccianoce S,Sakamoto M,Cuomo V

doi

10.1007/s00128-008-9557-8

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

539-42

issue

6

eissn

0007-4861

issn

1432-0800

journal_volume

81

pub_type

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