Abstract：
:Ninety term neonates with hyperbilirubinemia were studied with brainstem auditory evoked response to clarify the ototoxic effect of hyperbilirubinemia, and detect any differences in ototoxic effect between different levels of total serum bilirubin. The response threshold in these neonates was significantly elevated (P < 0.001). All wave latencies and I-V interval increased significantly (P < 0.05-0.0001), and correlated weakly with total serum bilirubin (r = 0.24-0.28, all P < 0.05). Twenty-five neonates (28%) had abnormal responses, including 14 (16%) with elevated thresholds or increased wave I latency, suggesting peripheral auditory impairment, and 16 (18%) with increased I-V interval, suggesting central auditory impairment. Wave V latency and I-V interval were longer in neonates with total serum bilirubin of <20 mg/dL than in those with bilirubin 11-15 mg/dL (P < 0.05). However, there were no significant differences in response variables between neonates with total serum bilirubin 11-15 mg/dL and those with bilirubin 16-20 mg/dL, and between neonates with bilirubin 16-20 mg/dL and those with bilirubin >20 mg/dL. Thus, although the acute ototoxic effect of hyperbilirubinemia tends to be more significant at a higher rather than lower level of total serum bilirubin, auditory impairment does not increase closely with the increase in bilirubin.
journal_name
Pediatr Neuroljournal_title
Pediatric neurologyauthors
Jiang ZD,Chen C,Liu TT,Wilkinson ARdoi
10.1016/j.pediatrneurol.2007.03.006subject
Has Abstractpub_date
2007-07-01 00:00:00pages
35-41issue
1eissn
0887-8994issn
1873-5150pii
S0887-8994(07)00127-0journal_volume
37pub_type
杂志文章abstract：:Nerve growth factor (NGF) in cerebrospinal fluid was measured by ELISA in ten children with postinfectious diseases and in five children with diseases suggested to be of autoimmune etiology. Three groups of patients were studied: (1) those with moderately elevated concentrations (50.67 +/- 17.02 pg/mL, mean and SEM), ...
journal_title：Pediatric neurology
pub_type： 杂志文章
doi：10.1016/s0887-8994(97)00204-x
更新日期：1998-03-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章
doi：10.1016/s0887-8994(98)00016-2
更新日期：1998-07-01 00:00:00
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journal_title：Pediatric neurology
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pub_type： 杂志文章,随机对照试验
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journal_title：Pediatric neurology
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journal_title：Pediatric neurology
pub_type： 杂志文章
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journal_title：Pediatric neurology
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更新日期：2016-02-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章
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journal_title：Pediatric neurology
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更新日期：2017-04-01 00:00:00
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journal_title：Pediatric neurology
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更新日期：2012-02-01 00:00:00
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更新日期：2005-10-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
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journal_title：Pediatric neurology
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更新日期：2009-02-01 00:00:00
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更新日期：2011-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：1998-05-01 00:00:00
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更新日期：2013-03-01 00:00:00
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journal_title：Pediatric neurology
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更新日期：2002-05-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章
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更新日期：1995-11-01 00:00:00
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journal_title：Pediatric neurology
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更新日期：2006-08-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章
doi：10.1016/j.pediatrneurol.2008.03.008
更新日期：2008-07-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
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journal_title：Pediatric neurology
pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
abstract：:Brain plasticity refers to its ability to recover after damage. Visual field plasticity is not well recognized. We report a 12-year-old female who first presented with recurrent seizures and was subsequently found to have a large, right occipital cortical dysplasia on magnetic resonance imaging. Her visual field by Go...
journal_title：Pediatric neurology
pub_type： 杂志文章
doi：10.1016/s0887-8994(00)00171-5
更新日期：2000-09-01 00:00:00
abstract：:Epilepsy is a serious chronic brain disorder of childhood. We performed a cross-sectional prevalence study, determined the prevalence of childhood epilepsy, and identified the significance of certain risk factors for epilepsy among 1625 primary-school students aged 6-14 years, living in the center of Kars province. A ...
journal_title：Pediatric neurology
pub_type： 杂志文章
doi：10.1016/j.pediatrneurol.2012.04.007
更新日期：2012-07-01 00:00:00
