Overstimulation of nerve growth factors in postinfectious and autoimmune diseases.

Abstract:

:Nerve growth factor (NGF) in cerebrospinal fluid was measured by ELISA in ten children with postinfectious diseases and in five children with diseases suggested to be of autoimmune etiology. Three groups of patients were studied: (1) those with moderately elevated concentrations (50.67 +/- 17.02 pg/mL, mean and SEM), (2) those with high concentrations (mean 424.25 +/- 125.41 pg/mL, mean and SEM), and (3) those with enormously high concentrations (mean 2,745 +/- 1,819.46 pg/mL, mean and SEM). We suggest that CSF-NGF could be used as an immunologic marker of an ongoing CNS process. Uncontrolled signaling of NGF receptors may lead to long-term inflammatory and autoimmune responses, which in turn can lead to disease.

journal_name

Pediatr Neurol

journal_title

Pediatric neurology

authors

Riikonen RS,Söderström S,Korhonen LT,Lindholm DB

doi

10.1016/s0887-8994(97)00204-x

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

231-5

issue

3

eissn

0887-8994

issn

1873-5150

pii

S088789949700204X

journal_volume

18

pub_type

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