Role of renin-angiotensin system in development of heart failure induced by myocardial infarction in rats.

Abstract:

:We investigated the morphologic and functional changes of infarcted rat hearts under a paradigm of angiotensinconverting enzyme inhibition. Myocardial infarction was induced by left coronary artery ligation and a control group (SHAM) underwent sham-operation. Infarcted rats received normal drinking water with (CAP group) or without (INF group) captopril. Functional assessment was performed by electro (ECG) and echocardiogram (ECHO) just before and 21 days after surgery. The ECG of INF and CAP showed similar values and resembled healed infarct after surgery. The most outstanding differences between INF and CAP were the prevention of the increase of P-wave and attenuation both in rightward deviation of the QRS axis and Q-wave amplitude in CAP compared with INF. The ECHO showed that captopril treatment improved the diastolic filling more than systolic performance. Cardiac dilatation and left congestive heart failure were observed only in INF. Both infarcted groups showed a scar tissue in the left ventricular wall, but the INF showed a higher scar area than CAP (49.7+/-5.24 vs. 22.33+/-6.19 respectively). These data suggest that the renin-angiotensin system induces morphologic and functional changes in post-infarcted rat hearts and which can be assessed by non-invasive exams.

journal_name

An Acad Bras Cienc

authors

Trindade DC,Trindade RC,Marassi MP,Martins OP,Costa-e-Sousa RH,Mattos EC,Marinho A Jr,Reis LC,Olivares EL

doi

10.1590/s0001-37652007000200008

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

251-9

issue

2

eissn

0001-3765

issn

1678-2690

pii

S0001-37652007000200008

journal_volume

79

pub_type

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