Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.

abstract：:An ACG codon, which replaces the AUG codon used to initiate the synthesis of bacteriophage T7 gene 0.3 protein, was shown to function as a low-efficiency initiation codon in a wheat germ cell-free protein-synthesizing system. ...

journal_title：Molecular and cellular biology

authors： Anderson CW,Buzash-Pollert E

更新日期：1985-12-01 00:00:00

abstract：:The rapid nuclear translocation of signaling proteins upon stimulation is important for the regulation of de novo gene expression. We have studied the stimulated nuclear shuttling of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases (MAPKs) and found that they translocate into the nucleus in a Ra...

journal_title：Molecular and cellular biology

authors： Zehorai E,Seger R

更新日期：2014-01-01 00:00:00

abstract：:Throughout life, intestinal Lgr5+ stem cells give rise to proliferating transient amplifying cells in crypts, which subsequently differentiate into one of the five main cell types and migrate along the crypt-villus axis. These dynamic processes are coordinated by a relatively small number of evolutionarily conserved s...

journal_title：Molecular and cellular biology

authors： van Es JH,Haegebarth A,Kujala P,Itzkovitz S,Koo BK,Boj SF,Korving J,van den Born M,van Oudenaarden A,Robine S,Clevers H

更新日期：2012-05-01 00:00:00

abstract：:Repeat-induced point mutation (RIP) is a process that efficiently detects DNA duplications prior to meiosis in Neurospora crassa and peppers them with G:C to A:T mutations. Cytosine methylation is typically associated with sequences affected by RIP, and methylated cytosines are not limited to CpG dinucleotides. We gen...

journal_title：Molecular and cellular biology

authors： Singer MJ,Marcotte BA,Selker EU

更新日期：1995-10-01 00:00:00

abstract：:Transcriptional coactivators play a crucial role in gene expression by communicating between regulatory factors and the basal transcription machinery. The coactivator multiprotein bridging factor 1 (MBF1) was originally identified as a bridging molecule that connects the Drosophila nuclear receptor FTZ-F1 and TATA-bin...

journal_title：Molecular and cellular biology

authors： Takemaru K,Harashima S,Ueda H,Hirose S

更新日期：1998-09-01 00:00:00

abstract：:S1 mapping of the termination region in the ribosomal DNA from a thermophilic fungus, Thermomyces lanuginosus, revealed three distinct termini corresponding to the mature 25S rRNA, a precursor that is 19 nucleotides longer and corresponds to the 37S precursor in yeast cells, and a putative termination site at +96 that...

journal_title：Molecular and cellular biology

authors： Walker K,Wong WM,Nazar RN

更新日期：1990-01-01 00:00:00

abstract：:We have constructed a recombinant pBR322 plasmid composed of a subgenomic transforming fragment of bovine papillomavirus DNA and the hepatitis B surface antigen gene from cloned hepatitis B virus DNA and used it for transfection of NIH 3T3 mouse fibroblasts. The transformed cells retain the plasmids in extrachromosoma...

journal_title：Molecular and cellular biology

authors： Wang Y,Stratowa C,Schaefer-Ridder M,Doehmer J,Hofschneider PH

更新日期：1983-06-01 00:00:00

abstract：:The molecular chaperone HSP90 regulates stability and function of multiple protein kinases. The HSP90-binding drug geldanamycin interferes with this activity and promotes proteasome-dependent degradation of most HSP90 client proteins. Geldanamycin also binds to GRP94, the HSP90 paralog located in the endoplasmic retic...

journal_title：Molecular and cellular biology

authors： Marcu MG,Doyle M,Bertolotti A,Ron D,Hendershot L,Neckers L

更新日期：2002-12-01 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, initially discovered as part of the NPM-ALK fusion protein, resulting from the t(2;5) translocation that is frequently associated with anaplastic large-cell lymphomas. The native ALK protein is normally expressed in the developing and, at a weaker level, ...

journal_title：Molecular and cellular biology

authors： Mourali J,Bénard A,Lourenço FC,Monnet C,Greenland C,Moog-Lutz C,Racaud-Sultan C,Gonzalez-Dunia D,Vigny M,Mehlen P,Delsol G,Allouche M

更新日期：2006-08-01 00:00:00

abstract：:Temporal analysis of DNA replication and histone mRNA accumulation in a hamster fibroblast cell cycle mutant (K12) showed that histone mRNA accumulates periodically during the cell cycle and reaches its highest level in the S phase. The direct correlation between the initiation of DNA synthesis and the accumulation of...

journal_title：Molecular and cellular biology

authors： Artishevsky A,Delegeane AM,Lee AS

更新日期：1984-11-01 00:00:00

abstract：:Okadaic acid-sensitive serine/threonine phosphatases have been shown to regulate interleukin-2 transcription and T-cell activation. Okadaic acid inhibits protein phosphatase 4 (PP4), a novel PP2A-related serine/threonine phosphatase, at a 50% inhibitory concentration (IC(50)) comparable to that for PP2A. This raises t...

journal_title：Molecular and cellular biology

authors： Shui JW,Hu MC,Tan TH

更新日期：2007-01-01 00:00:00

abstract：:Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and transported to the organelle by shuttling receptors. Matrix proteins containing a type 1 signal are carried to the peroxisome by PEX5, whereas those harboring a type 2 signal are transported by a PEX5-PEX7 complex. The pathway followed by PEX5 duri...

journal_title：Molecular and cellular biology

authors： Rodrigues TA,Alencastre IS,Francisco T,Brites P,Fransen M,Grou CP,Azevedo JE

更新日期：2014-08-01 00:00:00

abstract：:The Saccharomyces cerevisiae SWI4 gene encodes an essential transcription factor which controls gene expression at the G1/S transition of the cell cycle. SWI4 transcription itself is cell cycle regulated, and this periodicity is crucial for the normal cell cycle regulation of HO and at least two of the G1 cyclins. Sin...

journal_title：Molecular and cellular biology

authors： Foster R,Mikesell GE,Breeden L

更新日期：1993-06-01 00:00:00

abstract：:Eukaryotic flagella are complex organelles composed of more than 200 polypeptides. Little is known about the regulatory mechanisms governing synthesis of the flagellar protein subunits and their assembly into this complex organelle. The unicellular green alga Chlamydomonas reinhardtii is the premier experimental model...

journal_title：Molecular and cellular biology

authors： Periz G,Keller LR

更新日期：1997-07-01 00:00:00

abstract：:Nuclear expression and consequent biological action of the eukaryotic NF-kappa B transcription factor complex are tightly regulated through its cytoplasmic retention by an ankyrin-rich inhibitory protein termed I kappa B alpha. I kappa B alpha specifically binds to and masks the nuclear localization signal of the RelA...

journal_title：Molecular and cellular biology

authors： Sun S,Elwood J,Greene WC

更新日期：1996-03-01 00:00:00

abstract：:Calpains regulate a wide spectrum of biological functions, including migration, adhesion, apoptosis, secretion, and autophagy, through the modulating cleavage of specific substrates. Ubiquitous microcalpain (μ-calpain) and millicalpain (m-calpain) are heterodimers composed of catalytic subunits encoded, respectively, ...

journal_title：Molecular and cellular biology

authors： Cataldo F,Peche LY,Klaric E,Brancolini C,Myers MP,Demarchi F,Schneider C

更新日期：2013-06-01 00:00:00

abstract：:Selective and accurate transcription of purified genes by RNA polymerase II requires multiple factors. The factor designated TFIID was purified extensively from HeLa cell nuclear extracts by using a simple and novel complementation assay. Thus, TFIID was preferentially inactivated by mild heat treatment of a nuclear e...

journal_title：Molecular and cellular biology

authors： Nakajima N,Horikoshi M,Roeder RG

更新日期：1988-10-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) constitutes the most inherited kidney disease. Mutations in the PKD1 and PKD2 genes, encoding the polycystin 1 and polycystin 2 Ca2+ ion channels, respectively, result in tubular epithelial cell-derived renal cysts. Recent clinical studies demonstrate oxidative stre...

journal_title：Molecular and cellular biology

authors： Ishimoto Y,Inagi R,Yoshihara D,Kugita M,Nagao S,Shimizu A,Takeda N,Wake M,Honda K,Zhou J,Nangaku M

更新日期：2017-11-28 00:00:00

abstract：:Ikaros (Ik) is a critical regulator of hematopoietic gene expression. Here, we established that the Ik interactions with GATA transcription factors and cyclin-dependent kinase 9 (Cdk9), a component of the positive transcription elongation factor b (P-TEFb), are required for transcriptional activation of Ik target gene...

journal_title：Molecular and cellular biology

authors： Bottardi S,Mavoungou L,Bourgoin V,Mashtalir N,Affar el B,Milot E

更新日期：2013-08-01 00:00:00

abstract：:We analyzed the replication of two unlinked actin genes, ardB and ardC , which are abundantly transcribed in the naturally synchronous plasmodium of the slime mold Physarum polycephalum. Detection and size measurements of single-stranded nascent replication intermediates (RIs) demonstrate that these two genes are conc...

journal_title：Molecular and cellular biology

authors： Bénard M,Lagnel C,Pallotta D,Pierron G

更新日期：1996-03-01 00:00:00

abstract：:The carboxyl-terminal domain (CTD) of RNA polymerase II (Pol II) can be phosphorylated at serine 2 (Ser-2) and serine 5 (Ser-5) of the CTD heptad repeat YSPTSPS, and this phosphorylation is important in coupling transcription to RNA processing, including 5' capping, splicing, and polyadenylation. The mammalian endogen...

journal_title：Molecular and cellular biology

authors： Cheng C,Sharp PA

更新日期：2003-03-01 00:00:00

abstract：:Gene targeting is a very powerful tool for studying mammalian development and physiology and for creating models of human diseases. In many instances, however, it is desirable to study different modifications of a target gene, but this is limited by the generally low frequency of homologous recombination in mammalian ...

journal_title：Molecular and cellular biology

authors： Cohen-Tannoudji M,Robine S,Choulika A,Pinto D,El Marjou F,Babinet C,Louvard D,Jaisser F

更新日期：1998-03-01 00:00:00

abstract：:Nrdp1 is a RING finger-containing E3 ubiquitin ligase that physically interacts with and regulates steady-state cellular levels of the ErbB3 and ErbB4 receptor tyrosine kinases and has been implicated in the degradation of the inhibitor-of-apoptosis protein BRUCE. Here we demonstrate that the Nrdp1 protein undergoes e...

journal_title：Molecular and cellular biology

authors： Wu X,Yen L,Irwin L,Sweeney C,Carraway KL 3rd

更新日期：2004-09-01 00:00:00

abstract：:The tumor suppressor protein ARF inhibits MDM2 to activate and stabilize p53. Recent studies provided evidence for p53-independent tumor suppression functions of ARF. For example, it has been shown that ARF induces proteolysis of certain E2F species, including E2F1. In addition, ARF relocalizes E2F1 from the nucleopla...

journal_title：Molecular and cellular biology

authors： Datta A,Nag A,Raychaudhuri P

更新日期：2002-12-01 00:00:00

abstract：:The RHO1 gene encodes a homolog of the mammalian RhoA small GTP-binding protein in the yeast Saccharomyces cerevisiae. Rho1p is localized at the growth site and is required for bud formation. The RHO1(G22S, D125N) mutation is a temperature-sensitive and dominant negative mutation of RHO1, and a multicopy suppressor of...

journal_title：Molecular and cellular biology

authors： Hirano H,Tanaka K,Ozaki K,Imamura H,Kohno H,Hihara T,Kameyama T,Hotta K,Arisawa M,Watanabe T,Qadota H,Ohya Y,Takai Y

更新日期：1996-08-01 00:00:00

abstract：:Two signals activate meiosis in yeast: starvation and expression of the a1 and alpha 2 products of the mating-type locus. Prior studies suggest that these signals stimulate expression of an activator of meiosis, the IME1 (inducer of meiosis) product. We have cloned a gene, IME2, with properties similar to those of IME...

journal_title：Molecular and cellular biology

authors： Smith HE,Mitchell AP

更新日期：1989-05-01 00:00:00

abstract：:The response to amino acid starvation involves the global decrease of protein synthesis and an increase in the translation of some mRNAs that contain an internal ribosome entry site (IRES). It was previously shown that translation of the mRNA for the arginine/lysine amino acid transporter Cat-1 increases during amino ...

journal_title：Molecular and cellular biology

authors： Majumder M,Yaman I,Gaccioli F,Zeenko VV,Wang C,Caprara MG,Venema RC,Komar AA,Snider MD,Hatzoglou M

更新日期：2009-05-01 00:00:00

abstract：:We utilized the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) in vivo to understand how the interaction of the glucocorticoid receptor (GR) with a nucleosome-assembled promoter allows access of factors required for the transition from a repressed promoter to a derepressed, transcriptionally competent pro...

journal_title：Molecular and cellular biology

authors： Sheldon LA,Smith CL,Bodwell JE,Munck AU,Hager GL

更新日期：1999-12-01 00:00:00

abstract：:Both chemotaxis and phagocytosis depend upon actin-driven cell protrusions and cell membrane remodeling. While chemoattractant receptors rely upon canonical G-protein signaling to activate downstream effectors, whether such signaling pathways affect phagocytosis is contentious. Here, we report that Gαi nucleotide exch...

journal_title：Molecular and cellular biology

authors： Huang NN,Becker S,Boularan C,Kamenyeva O,Vural A,Hwang IY,Shi CS,Kehrl JH

更新日期：2014-11-15 00:00:00

abstract：:Epidermal growth factor (EGF) receptor (EGFR) has been implicated in tumor development and invasion. Dimerization and autophosphorylation of EGFR are the critical events for EGFR activation. However, the regulation of EGF-dependent and EGF-independent dimerization and phosphorylation of EGFR has not been fully underst...

journal_title：Molecular and cellular biology

authors： Arimoto K,Burkart C,Yan M,Ran D,Weng S,Zhang DE

更新日期：2014-10-01 00:00:00