A transcriptional cascade governs entry into meiosis in Saccharomyces cerevisiae.

Abstract:

:Two signals activate meiosis in yeast: starvation and expression of the a1 and alpha 2 products of the mating-type locus. Prior studies suggest that these signals stimulate expression of an activator of meiosis, the IME1 (inducer of meiosis) product. We have cloned a gene, IME2, with properties similar to those of IME1: both genes are required for meiosis, and both RNAs are induced in meiotic cells. Elevated dosage of IME1 or IME2 stimulates the meiotic recombination pathway without starvation; thus, the IME products may be part of the switch that activates meiosis. IME1 was found to be required for IME2 expression, and a multicopy IME2 plasmid permitted meiosis in an ime1 deletion mutant. Accordingly, we propose that the IME1 product stimulates meiosis mainly through activation of IME2 expression.

journal_name

Mol Cell Biol

authors

Smith HE,Mitchell AP

doi

10.1128/mcb.9.5.2142

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

2142-52

issue

5

eissn

0270-7306

issn

1098-5549

journal_volume

9

pub_type

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