Abstract：
:Nucleoside hydrolase (NH) is a key enzyme in the purine salvage pathway. The purine specificity of the IAG-NH from Trypanosoma vivax is at least in part due to cation-pi-stacking interactions. Guanidinium ions can be involved in cation-pi-stacking interactions, therefore a series of guanidino-alkyl-ribitol derivatives were synthesized in order to examine the binding affinity of these compounds towards the target enzyme. The compounds show moderate to good inhibiting activity towards the IAG-NH from T. vivax.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Goeminne A,McNaughton M,Bal G,Surpateanu G,Van Der Veken P,De Prol S,Versées W,Steyaert J,Haemers A,Augustyns Kdoi
10.1016/j.ejmech.2007.03.027subject
Has Abstractpub_date
2008-02-01 00:00:00pages
315-26issue
2eissn
0223-5234issn
1768-3254pii
S0223-5234(07)00160-2journal_volume
43pub_type
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