Reliability of sentinel lymph-node extirpation as a diagnostic method for malignant melanoma of the head and neck region.

Abstract:

:A series of 106 patients with malignant melanoma of the head and neck and clinically negative local lymph-node status were included in a multimodal therapy programme and underwent sentinel lymph-node extirpation in 1999-2003. Out of 246 preoperatively marked lymph nodes, only 172 (70%) were identified intraoperatively and removed. In 89% of all patients at least one sentinel lymph node was removed. Histological examination revealed metastases in the sentinel lymph nodes of 17 patients. In the mean follow-up period of 47 months (range 4-76 months), regional lymph-node metastases were found in another eight patients. The non-marked lymph nodes that were often removed at the same time, in an elective cervical lymph-node dissection, did not reveal any metastasis in any of the cases where the sentinel lymph nodes were negative. The sensitivity of sentinel lymph-node extirpation was influenced by the length of the follow-up period and the detection rate, and was 68% (17/17+8), a result superior to that of any other diagnostic tool. Sentinel lymph-node extirpation is a valuable method in addition to elective lymph-node dissection.

authors

Teltzrow T,Osinga J,Schwipper V

doi

10.1016/j.ijom.2007.02.007

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

481-7

issue

6

eissn

0901-5027

issn

1399-0020

pii

S0901-5027(07)00101-4

journal_volume

36

pub_type

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