当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY期刊下所有文献 > Bone substitute material composition and morphology differentially modulate calcium and phosphate release through osteoclast-like cells.

Bone substitute material composition and morphology differentially modulate calcium and phosphate release through osteoclast-like cells.

Abstract：

:The aim of this study was to determine the material composition and cell-mediated remodelling of different calcium phosphate-based bone substitutes. Osteoclasts were cultivated on bone substitutes (Cerabone, Maxresorb, and NanoBone) for up to 5 days. Bafilomycin A1 addition served as the control. To determine cellular activity, the supernatant content of calcium and phosphate was measured by inductively coupled plasma optical emission spectrometry. Cells were visualized on the materials by scanning electron microscopy. Material composition and surface characteristics were assessed by energy-dispersive X-ray spectroscopy. Osteoclast-induced calcium and phosphate release was material-specific. Maxresorb exhibited the highest ion release to the medium (P = 0.034; calcium 40.25mg/l day 5, phosphate 102.08 mg/l day 5) and NanoBone the lowest (P = 0.021; calcium 8.43 mg/l day 5, phosphate 15.15 mg/l day 5); Cerabone was intermediate (P = 0.034; calcium 16.34 mg/l day 5, phosphate 30.6 mg/l day 5). All investigated materials showed unique resorption behaviours. The presented methodology provides a new perspective on the investigation of bone substitute biodegradation, maintaining the material-specific micro- and macrostructure.

journal_name

Int J Oral Maxillofac Surg

journal_title

International journal of oral and maxillofacial surgery

authors

Konermann A,Staubwasser M,Dirk C,Keilig L,Bourauel C,Götz W,Jäger A,Reichert C

doi

10.1016/j.ijom.2013.10.017

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

514-21

issue

4

eissn

0901-5027

issn

1399-0020

pii

S0901-5027(13)01156-9

journal_volume

43

pub_type

杂志文章

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