Lymphocytes at tumor margins in patients with head and neck cancer. Relationship with tumor size, human lymphocyte antigen molecules, and metastasis.

Abstract:

:A series of 76 patients with head and neck squamous cell carcinoma (HNSCC) was analyzed for the significance of a peritumoral lymphocytic infiltrate (PLI). The composition of PLI was immunohistochemically investigated in frozen material and correlated with other putative prognostically significant variables. PLI was shown to be correlated with the invasion pattern but not with any of the other investigated variables such as tumor size, thickness, and metastasis. However, individual components of PLI were statistically significant: human lymphocyte antigen (HLA)-class II-positive cells correlated with occurrence of metastasis, and CD22-positive cells correlated with tumor size. We conclude that studies on the significance of PLI in HNSCC patients should concentrate on analysis of its individual components.

authors

Slootweg PJ,de Pagter M,de Weger RA,de Wilde PC

doi

10.1016/s0901-5027(05)80110-9

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

286-9

issue

5

eissn

0901-5027

issn

1399-0020

journal_volume

23

pub_type

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