Abstract:
:We describe a patient with type 2N von Willebrand's disease scheduled for elective coronary artery bypass graft for severe three-vessel coronary artery disease with involvement of the left main stem. He was given a pre-operative bolus of 3000 IU factor VIII/Willebrand factor concentrate (approximately 40 IU.kg(-1)), followed by a continuous infusion of 3 IU.h(-1) (228 IU.h(-1)) before undergoing coronary surgery with full heparinisation and cardiopulmonary bypass. There were no intra-operative bleeding complications and only one unit of packed red blood cells was required postoperatively. Thromboprophylaxis with low-molecular weight heparin and aspirin was given and the infusion of factor VIII/von Willebrand factor concentrate continued for 2 days. As a result of haematological monitoring, heparin therapy was changed from prophylactic to therapeutic on day 5-6 and stopped on day 7.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Gerling V,Lahpor JR,Buhre Wdoi
10.1111/j.1365-2044.2007.05001.xsubject
Has Abstractpub_date
2007-04-01 00:00:00pages
405-8issue
4eissn
0003-2409issn
1365-2044pii
ANA5001journal_volume
62pub_type
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