Cognitive flexibility in phenotypes of pediatric bipolar disorder.

Abstract:

OBJECTIVE:Clinicians and researchers debate whether children with chronic, nonepisodic irritability should receive the diagnosis of bipolar disorder (BD). To address this debate, we evaluated cognitive flexibility, or the ability to adapt to changing contingencies, in three groups of children: narrow-phenotype BD (NP-BD; full-duration manic episodes of elevated/expansive mood; N = 50; 13.1 +/- 2.9 years), severe mood dysregulation (SMD; chronic, nonepisodic irritability; N = 44; 12.2 +/- 2.1 years), and healthy controls (N = 43; 13.6 +/- 2.4 years). Cognitive flexibility is relevant to symptoms of BD involving dysfunctional reward systems (e.g., excessive goal-directed activity and pleasure-seeking in mania; anhedonia in depression). METHOD:We studied simple and compound reversal stages of the intra-/extradimensional shift task and change task that involves inhibiting a prepotent response and substituting a novel response. RESULTS:On the simple reversal, NP-BD youths were significantly more impaired than both the SMD group and controls. On the compound reversal, NP-BD and SMD youths performed worse than controls. On the change task, NP-BD youths were slower to adapt than SMD subjects. CONCLUSIONS:Phenotypic differences in cognitive flexibility may reflect different brain/behavior mechanisms in these two patient populations.

authors

Dickstein DP,Nelson EE,McCLURE EB,Grimley ME,Knopf L,Brotman MA,Rich BA,Pine DS,Leibenluft E

doi

10.1097/chi.0b013e31802d0b3d

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

341-355

issue

3

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)61678-6

journal_volume

46

pub_type

杂志文章
  • Parent-teacher concordance for DSM-IV attention-deficit/hyperactivity disorder in a clinic-referred sample.

    abstract:OBJECTIVE:To examine concordance between parent and teacher reports of DSM-IV attention-deficit/hyperactivity disorder (ADHD) and its symptoms. METHOD:Parents and teachers of 74 clinically referred children were interviewed using the ADHD module of the Diagnostic Interview Schedule for Children. Parent-teacher agreeme...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200003000-00012

    authors: Mitsis EM,McKay KE,Schulz KP,Newcorn JH,Halperin JM

    更新日期:2000-03-01 00:00:00

  • General medical problems among the offspring of depressed parents: a 10-year follow-up.

    abstract:OBJECTIVE:To examine the association between both parental and offspring depression and the general medical problems of a sample of offspring at high and low risk for depression. METHOD:Offspring (n = 222) from families with either depressed or nondepressed parents were followed up for a period of 10 years. Data colle...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199806000-00010

    authors: Kramer RA,Warner V,Olfson M,Ebanks CM,Chaput F,Weissman MM

    更新日期:1998-06-01 00:00:00

  • Genetic contributions to the development of ADHD subtypes from childhood to adolescence.

    abstract:OBJECTIVES:Little is known about how genes influence the development of symptoms included in the DSM-IV subtypes of attention-deficit/hyperactivity disorder (ADHD) from childhood to adolescence. The aim of this study was to examine genetic influences contributing to the development of hyperactive-impulsive symptoms and...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.chi.0000222787.57100.d8

    authors: Larsson H,Lichtenstein P,Larsson JO

    更新日期:2006-08-01 00:00:00

  • Revisiting the factor structure of the strengths and difficulties questionnaire: United States, 2001.

    abstract:OBJECTIVE:The Strengths and Difficulties Questionnaire is a 25-item instrument developed to assess emotional and behavioral problems. The current study attempted to replicate previous European structural analyses and to describe the latent dimensions that underlie responses to the parent-reported version of the Strengt...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.chi.0000132808.36708.a9

    authors: Dickey WC,Blumberg SJ

    更新日期:2004-09-01 00:00:00

  • The Internal, External, and Diagnostic Validity of Sluggish Cognitive Tempo: A Meta-Analysis and Critical Review.

    abstract:OBJECTIVE:To conduct the first meta-analysis evaluating the internal and external validity of the sluggish cognitive tempo (SCT) construct as related to or distinct from attention-deficit/hyperactivity disorder (ADHD) and as associated with functional impairment and neuropsychological functioning. METHOD:Electronic da...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.jaac.2015.12.006

    authors: Becker SP,Leopold DR,Burns GL,Jarrett MA,Langberg JM,Marshall SA,McBurnett K,Waschbusch DA,Willcutt EG

    更新日期:2016-03-01 00:00:00

  • Clozapine for the treatment of adolescents with schizophrenia.

    abstract::Despite recent reports that clozapine is useful for the treatment of chronic schizophrenics resistant to neuroleptics, no studies have been reported in adolescents with schizophrenia. Despite the risk of potentially fatal agranulocytosis, clozapine's use in adolescents may become important because of its lack of extra...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199201000-00024

    authors: Birmaher B,Baker R,Kapur S,Quintana H,Ganguli R

    更新日期:1992-01-01 00:00:00

  • Methylphenidate and thioridazine in the treatment of intellectually subaverage children: effects on cognitive-motor performance.

    abstract::Twenty-seven children (or smaller subgroups depending upon task difficulty and subject ability) with subaverage IQs took part in a double-blind, placebo-controlled, cross-over study of methylphenidate (0.4 mg/kg/day) and thioridazine (1.75 mg/kg/day). The children were tested for IQ performance, breadth of attention, ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Aman MG,Marks RE,Turbott SH,Wilsher CP,Merry SN

    更新日期:1991-09-01 00:00:00

  • Children's discrimination of expressions of emotions: relationship with indices of social anxiety and shyness.

    abstract:OBJECTIVE:To conduct an exploratory investigation of possible relationships between individual levels of social anxiety and the ability to classify emotional expressions in a group of schoolchildren observing pictures of children of similar age. METHOD:One hundred forty-nine second- and third-grade schoolchildren unde...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004583-200403000-00019

    authors: Battaglia M,Ogliari A,Zanoni A,Villa F,Citterio A,Binaghi F,Fossati A,Maffei C

    更新日期:2004-03-01 00:00:00

  • Depressive disorders in maltreated children.

    abstract::This study examined the prevalence of depressive disorders in a sample of 56 7- to 12-year-old maltreated children. Overall, 18% of the sample met the diagnostic criteria for major depression, and 25% met the criteria for dysthymia, with the majority of the children who met the criteria for major depression also meeti...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199103000-00014

    authors: Kaufman J

    更新日期:1991-03-01 00:00:00

  • Case study: behavioral symptoms of pediatric HIV-1 encephalopathy successfully treated with clonidine.

    abstract::There are few reports of the behavioral manifestations in the pediatric population infected with human immunodeficiency virus type 1 (HIV-1). We report a case of a 4-year-old child with acquired immunodeficiency syndrome, whose initial manifestation of central nervous system involvement consisted of sudden onset of im...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199503000-00014

    authors: Ceseña M,Lee DO,Cebollero AM,Steingard RJ

    更新日期:1995-03-01 00:00:00

  • LGBT Youth, Mental Health, and Spiritual Care: Psychiatric Collaboration With Health Care Chaplains.

    abstract::Lesbian, gay, bisexual, and transgender (LGBT) youth have unique medical and mental health needs. Exposure to stigma such as family non-acceptance is associated with adverse mental health outcomes that are important sources of morbidity and mortality in this population. These include depression, anxiety, substance abu...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 社论

    doi:10.1016/j.jaac.2019.02.009

    authors: Adelson SL,Walker-Cornetta E,Kalish N

    更新日期:2019-07-01 00:00:00

  • Further evidence of a bidirectional overlap between juvenile mania and conduct disorder in children.

    abstract:OBJECTIVE:To investigate systematically the overlap between mania and conduct disorder (CD) in a sample of consecutively referred youths. It was hypothesized that neither CD nor manic symptoms were secondary to the other disorder and that children with the 2 disorders would have correlates of both. METHOD:Subjects wer...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199904000-00021

    authors: Biederman J,Faraone SV,Chu MP,Wozniak J

    更新日期:1999-04-01 00:00:00

  • Tricyclic antidepressants and cardiac autonomic control in children and adolescents.

    abstract:OBJECTIVE:To elucidate the effects of tricyclic antidepressants on sympathetic and vagal modulation of heart rate variability. METHOD:Seventy-five children and adolescents (mean age 10.5 years, SD 2.0) from therapeutic and regular schools underwent challenges of paced breathing and orthostatic postural change, while h...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199801000-00017

    authors: Mezzacappa E,Steingard R,Kindlon D,Saul JP,Earls F

    更新日期:1998-01-01 00:00:00

  • Longitudinal patterns of cortisol regulation differ in maltreated and nonmaltreated children.

    abstract:OBJECTIVE:Child maltreatment is associated with dysregulation of stress-mediating systems and an increased risk of mental and physical health problems. Specifically, disruptions in hypothalamic-pituitary-adrenal (HPA) axis regulation have been reported in maltreated children. The current study investigates whether incr...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2014.08.006

    authors: Doom JR,Cicchetti D,Rogosch FA

    更新日期:2014-11-01 00:00:00

  • Impact of reimbursement systems on child psychiatrists: a comparison of Canada and the United States.

    abstract:OBJECTIVE:This study measured satisfaction of US and Canadian child psychiatrists with quality of care in their field and behaviors of their payers. METHOD:US and Canadian child psychiatrists were surveyed concerning time spent on billing paperwork, waiting times for psychiatrist reimbursement and patient treatment, a...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199510000-00018

    authors: Newell AR,Saltzman GM

    更新日期:1995-10-01 00:00:00

  • Latent class analysis of Child Behavior Checklist attention problems.

    abstract:OBJECTIVE:To test whether attention problems in children are continuously distributed or categorically discrete, the authors performed latent class analyses (LCA) of items from the Attention Problems scale of the Child Behavior Checklist (CBCL) using data from the clinical and nonclinical samples used in the derivation...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199908000-00014

    authors: Hudziak JJ,Wadsworth ME,Heath AC,Achenbach TM

    更新日期:1999-08-01 00:00:00

  • Predicting child PTSD: the relationship between acute stress disorder and PTSD in injured children.

    abstract:OBJECTIVE:To examine the prevalence of acute stress disorder (ASD) and posttraumatic stress disorder (PTSD) in injured children and to evaluate the utility of ASD as a predictor of PTSD. METHOD:Children hospitalized for injuries sustained in a traffic crash were enrolled in a prospective study. ASD was assessed in 243...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200404000-00006

    authors: Kassam-Adams N,Winston FK

    更新日期:2004-04-01 00:00:00

  • First-time suicide attempters, repeat attempters, and previous attempters on an adolescent inpatient psychiatry unit.

    abstract:OBJECTIVE:To compare clinical characteristics of hospitalized adolescents who (1) have recently made their first suicide attempt, (2) have recently made a second or subsequent attempt, (3) have made previous but no recent attempts, or (4) have never made an attempt. METHOD:Semistructured psychiatric diagnostic intervi...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199605000-00018

    authors: Goldston DB,Daniel S,Reboussin DM,Kelley A,Ievers C,Brunstetter R

    更新日期:1996-05-01 00:00:00

  • The DISC Predictive Scales (DPS): efficiently screening for diagnoses.

    abstract:OBJECTIVE:To derive and test a series of brief diagnosis-specific scales to identify subjects who are at high probability of meeting diagnostic criteria and those who may safely be spared more extensive diagnostic inquiry. METHOD:Secondary data analysis of a large epidemiological data set (n = 1,286) produced a series...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200104000-00013

    authors: Lucas CP,Zhang H,Fisher PW,Shaffer D,Regier DA,Narrow WE,Bourdon K,Dulcan MK,Canino G,Rubio-Stipec M,Lahey BB,Friman P

    更新日期:2001-04-01 00:00:00

  • Autistic Traits and Suicidal Thoughts, Plans, and Self-Harm in Late Adolescence: Population-Based Cohort Study.

    abstract:OBJECTIVE:To examine the hypothesis that autism spectrum disorders (ASD) diagnosis and traits in childhood are associated with suicidal thoughts, plans and self-harm at 16 years, and that any observed associations are explained by depression at 12 years. METHOD:We examined associations between ASD diagnosis and 4 dich...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/j.jaac.2018.01.023

    authors: Culpin I,Mars B,Pearson RM,Golding J,Heron J,Bubak I,Carpenter P,Magnusson C,Gunnell D,Rai D

    更新日期:2018-05-01 00:00:00

  • Hopelessness in inpatient youths: a closer look at behavior, emotional expression, and social support.

    abstract:OBJECTIVE:To examine the individual and family characteristics of children and adolescents with high levels of hopelessness. METHOD:One hundred inpatient youngsters participated in the study. Several measures, including the Hopelessness Scale for Children, Problem Behavior Scale of the Scales of Independent Behavior, ...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1016/S0890-8567(09)66575-8

    authors: Kashani JH,Suarez L,Allan WD,Reid JC

    更新日期:1997-11-01 00:00:00

  • Child Stress Disorders Checklist: a measure of ASD and PTSD in children.

    abstract:OBJECTIVE:To assess the psychometric properties of the Child Stress Disorders Checklist (CSDC), a 36-item observer-report instrument that measures acute stress and posttraumatic symptoms in children. METHOD:The CSDC was administered to parents of 43 children with acute burns and 41 children who had experienced a traff...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/01.CHI.0000046887.27264.F3

    authors: Saxe G,Chawla N,Stoddard F,Kassam-Adams N,Courtney D,Cunningham K,Lopez C,Hall E,Sheridan R,King D,King L

    更新日期:2003-08-01 00:00:00

  • Anxiety, affect, and activity in teenagers: monitoring daily life with electronic diaries.

    abstract:OBJECTIVE:The everyday experiences of a community sample of adolescents differing in anxiety level were compared by means of electronic diaries. METHOD:One hundred fifty-five ninth-grade adolescents completed electronic diaries every 30 minutes for two 4-day intervals, reporting their moods, activities, social setting...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200206000-00005

    authors: Henker B,Whalen CK,Jamner LD,Delfino RJ

    更新日期:2002-06-01 00:00:00

  • Childhood behavioral profiles leading to adolescent conduct disorder: risk trajectories for boys and girls.

    abstract:OBJECTIVE:To examine the link between childhood behavioral dimensions and adolescent conduct disorder (CD) among a large sample of boys and girls monitored longitudinally. METHOD:Teachers rated the behaviors of 1,569 children every year between kindergarten and grade 6. On the basis of these seven yearly ratings, grou...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-200209000-00009

    authors: Coté S,Tremblay RE,Nagin DS,Zoccolillo M,Vitaro F

    更新日期:2002-09-01 00:00:00

  • A randomized placebo-controlled trial of a school-based depression prevention program.

    abstract:OBJECTIVE:To conduct a placebo-controlled study of the effectiveness of a universal school-based depression prevention program. METHOD:Three hundred ninety-two students age 13 to 15 from two schools were randomized to intervention (RAP-Kiwi) and placebo programs run by teachers. RAP-Kiwi was an 11-session manual-based...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004583-200405000-00007

    authors: Merry S,McDowell H,Wild CJ,Bir J,Cunliffe R

    更新日期:2004-05-01 00:00:00

  • Familial dyslexia: use of genetic linkage data to define subtypes.

    abstract::Specific reading disability is an example of a complex behavioral disorder which is clinically heterogeneous. It is probably also heterogeneous at the levels of etiology and process (pathogenesis), but there may not be a 1:1:1 mapping of etiology to process to clinical outcome. Thus, classification of cases by clinica...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199003000-00008

    authors: Smith SD,Pennington BF,Kimberling WJ,Ing PS

    更新日期:1990-03-01 00:00:00

  • Monoamine oxidase inhibitor toxicity.

    abstract::Monoamine oxidase inhibitor (MAOI) drugs are used in the treatment of depressive and anxiety disorders in adults. MAOIs are also used in high doses for the treatment of lymphomas and of central nervous system (CNS) tumors in children. Toxic effects resulted when procarbazine, a drug of this class, was used in treating...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-198911000-00024

    authors: Pfefferbaum B,Pack R,van Eys J

    更新日期:1989-11-01 00:00:00

  • Structure of obsessive-compulsive symptoms in pediatric OCD.

    abstract:OBJECTIVE:It is unclear whether the structure of obsessive-compulsive disorder (OCD) symptoms seen in adults is preserved in pediatric samples. METHOD:A total of 238 children and adolescents referred to a specialty pediatric OCD clinic were administered the Children's Yale-Brown Obsessive Compulsive Scale Symptom Chec...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/CHI.0b013e31816b73c0

    authors: Mataix-Cols D,Nakatani E,Micali N,Heyman I

    更新日期:2008-07-01 00:00:00

  • Cellular immunity in depressed, conduct disorder, and normal adolescents: role of adverse life events.

    abstract:OBJECTIVE:To determine whether adolescents with major depressive disorder have disturbances in their cellular immunity and to study whether the immunological changes detected are specific to depression or are general responses to stress. METHOD:Twenty subjects with major depressive disorder, 17 nondepressed subjects w...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章

    doi:10.1097/00004583-199406000-00008

    authors: Birmaher B,Rabin BS,Garcia MR,Jain U,Whiteside TL,Williamson DE,al-Shabbout M,Nelson BC,Dahl RE,Ryan ND

    更新日期:1994-06-01 00:00:00

  • Depressive symptoms and clinical status during the Treatment of Adolescent Suicide Attempters (TASA) Study.

    abstract:OBJECTIVE:To examine the course of depression during the treatment of adolescents with depression who had recently attempted suicide. METHOD:Adolescents (N = 124), ages 12 to 18 years, with a 90-day history of suicide attempt, a current diagnosis of depressive disorder (96.0% had major depressive disorder), and a Chil...

    journal_title:Journal of the American Academy of Child and Adolescent Psychiatry

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/CHI.0b013e3181b5db66

    authors: Vitiello B,Brent DA,Greenhill LL,Emslie G,Wells K,Walkup JT,Stanley B,Bukstein O,Kennard BD,Compton S,Coffey B,Cwik MF,Posner K,Wagner A,March JS,Riddle M,Goldstein T,Curry J,Capasso L,Mayes T,Shen S,Gugga SS,

    更新日期:2009-10-01 00:00:00