Familial dyslexia: use of genetic linkage data to define subtypes.

Abstract:

:Specific reading disability is an example of a complex behavioral disorder which is clinically heterogeneous. It is probably also heterogeneous at the levels of etiology and process (pathogenesis), but there may not be a 1:1:1 mapping of etiology to process to clinical outcome. Thus, classification of cases by clinical features may not lead to discovery of the underlying processes or etiologies, and it may be profitable to define subgroups by etiology. There is evidence for genetic etiology in some cases, but there is genetic heterogeneity as well. Possible genetic models for specific reading disability include polygenic, oligogenic, and single gene inheritance, and there are several types of genetic analysis that can be used to determine which of these modes of inheritance may be present. Identification of individual genes is possible in single gene and oligogenic disorders. Clinical studies and molecular analysis can then be used to determine gene function.

authors

Smith SD,Pennington BF,Kimberling WJ,Ing PS

doi

10.1097/00004583-199003000-00008

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

204-13

issue

2

eissn

0890-8567

issn

1527-5418

pii

S0890-8567(09)65509-X

journal_volume

29

pub_type

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