NHSBSP type 1 interval cancers: a scientifically valid grouping?

Abstract:

AIM:To assess whether there are differences in the pathological features or survival between the new National Health Service Breast Screening Programme (NHSBSP) interval cancer classification system category of type 1 interval cancers, and the previously used, separate categories of occult, unclassified, and true interval cancers. MATERIALS AND METHODS:The prognostic pathological features (grade, lymph node stage, size, vascular invasion, oestrogen receptor status, and histological type) and survival of 428 type 1 interval invasive breast cancers were analysed by subgroup (occult, unclassified and true interval). RESULTS:Occult cancers compared with other type 1 interval cancers were of significantly lower grade [38 of 52 (73%) versus 151 of 340 (44%) grade 1 or 2, p=0.0005], more likely to be smaller size [37 of 51 (73%) versus 158 of 341 (46%) <20mm, p=0.0003] and more frequently of lobular type at histology [14 of 42 (32%) versus 50 of 286 (17%), p=0.03]. There was no significant difference in pathological features of unclassified tumours compared with other type 1 tumours. There was no significant survival difference between different type 1 subgroups (p=0.12). CONCLUSION:The NHSBSP type 1 interval cancers are a heterogeneous grouping with markedly differing pathological features. However, no significant survival difference is seen between the different type 1 subgroups.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Porter GJ,Evans AJ,Burrell HC,Lee AH,Chakrabarti J

doi

10.1016/j.crad.2006.10.002

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

262-7

issue

3

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(06)00360-6

journal_volume

62

pub_type

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