Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.

abstract：:Thyroid neoplasms show a wide variety of lesions varying from slowly growing differentiated adenocarcinomas to rapidly proliferating undifferentiated carcinomas. There has been some histopathological evidence that the undifferentiated thyroid carcinomas are derived from differentiated carcinomas. Moreover, it is suspe...

journal_title：Cancer research

authors： Ito T,Seyama T,Mizuno T,Tsuyama N,Hayashi T,Hayashi Y,Dohi K,Nakamura N,Akiyama M

更新日期：1992-03-01 00:00:00

abstract：:From February 7-11, 2011, the multidisciplinary Lorentz Workshop Circulating Tumor Cell (CTC) Isolation and Diagnostics: Toward Routine Clinical Use was held in Leiden (The Netherlands) to discuss progress and define challenges and potential solutions for development of clinically useful circulating tumor cell (CTC) d...

journal_title：Cancer research

authors： van de Stolpe A,Pantel K,Sleijfer S,Terstappen LW,den Toonder JM

更新日期：2011-09-15 00:00:00

abstract：:Experimental studies using murine tumor models have demonstrated that potent systemic immunity can be generated using tumor vaccines engineered by gene transfer to secrete certain cytokines. The underlying physiological principle behind these strategies involves the sustained release of high doses of cytokine at the s...

journal_title：Cancer research

authors： Golumbek PT,Azhari R,Jaffee EM,Levitsky HI,Lazenby A,Leong K,Pardoll DM

更新日期：1993-12-15 00:00:00

abstract：:p21(Cip1) is a cyclin-dependent kinase inhibitor whose abundance increases in cells exposed to radiation or other DNA-damaging agents. Such increases activate a G1 checkpoint, which allows time for DNA repair before S phase entry. By inhibiting cell cycle progression, p21(Cip1) potentially suppresses tumorigenesis, an...

journal_title：Cancer research

authors： Jackson RJ,Engelman RW,Coppola D,Cantor AB,Wharton W,Pledger WJ

更新日期：2003-06-15 00:00:00

abstract：:Increasing evidence points to an active stromal involvement in cancer initiation and progression. Cytokines derived from tumor cells are believed to modulate stromal cells to produce growth and angiogenic factors, which in turn provide the tumor with the necessary microenvironment for expansion and invasion. Transform...

journal_title：Cancer research

authors： Verona EV,Elkahloun AG,Yang J,Bandyopadhyay A,Yeh IT,Sun LZ

更新日期：2007-06-15 00:00:00

abstract：:Epithelial ovarian cancer comprises three major histological subtypes (serous, mucinous, and endometrioid), and it is becoming clear that the developmental pathways for these subtypes are fundamentally different. In particular, endometrioid ovarian cancers probably arise by the malignant transformation of ectopic endo...

journal_title：Cancer research

authors： Obata K,Morland SJ,Watson RH,Hitchcock A,Chenevix-Trench G,Thomas EJ,Campbell IG

更新日期：1998-05-15 00:00:00

abstract：:Two mutations of the ATM gene were recently suggested to confer breast cancer risks similar to mutations of BRCA1 or BRCA2. Here, we set out to confirm these findings in 961 families with non-BRCA1/BRCA2 breast cancer from diverse geographical regions. We did not detect the ATM 7271T-->G mutation in any family. The AT...

journal_title：Cancer research

authors： Szabo CI,Schutte M,Broeks A,Houwing-Duistermaat JJ,Thorstenson YR,Durocher F,Oldenburg RA,Wasielewski M,Odefrey F,Thompson D,Floore AN,Kraan J,Klijn JG,van den Ouweland AM,Wagner TM,Devilee P,Simard J,van 't Veer LJ,G

更新日期：2004-02-01 00:00:00

abstract：:Translocation of the bcl-2 gene to the immunoglobulin heavy chain gene is the most common alteration in follicular lymphoma. The result is the deregulated expression of bcl-2 and increased resistance to cell death. Regulation of the immunoglobulin heavy chain gene is controlled in part by four DNase I-hypersensitive r...

journal_title：Cancer research

authors： Heckman CA,Cao T,Somsouk L,Duan H,Mehew JW,Zhang CY,Boxer LM

更新日期：2003-10-15 00:00:00

abstract：:Two distinct marker chromosomes, presenting with intercalated C- and distamycin A-Dapi-positive regions, were observed in a metastatic and a primary melanoma. To establish the origin of these heterochromatic sequences, we performed in situ hybridization analysis using specific probes for human repetitive DNA. The mark...

journal_title：Cancer research

authors： Doneda L,Ginelli E,Agresti A,Larizza L

更新日期：1989-01-15 00:00:00

abstract：:A major problem remaining in the evaluation of boronated compounds for neutron capture therapy (NCT) is the need to know the intra- or extracellular microdistribution of boron. This is a consequence of the short range of the 10B(n,alpha)7Li reaction products (approximately 10 microns), such that biological efficacy is...

journal_title：Cancer research

authors： Fairchild RG,Kahl SB,Laster BH,Kalef-Ezra J,Popenoe EA

更新日期：1990-08-15 00:00:00

abstract：:An animal lectin purified from loach (Misgurnus anguillicaudatus) eggs induced release of cytotoxin from fresh bone marrow cells from mice, although the other lectins tested, wheat germ agglutinin, concanavalin A, and phytohemagglutinin did not. The cytotoxin released from bone marrow cells was a heat-labile protein w...

journal_title：Cancer research

authors： Okutomi T,Nakajima Y,Sakakibara F,Kawauchi H,Yamazaki M

更新日期：1987-01-01 00:00:00

abstract：:The RNA-binding protein PNO1 is critical for ribosome biogenesis, but its potential role in cancer remains unknown. In this study, online data mining, cDNA, and tissue microarrays indicated that PNO1 expression was higher in colorectal cancer tissue than in noncancerous tissue, and its overexpression was associated wi...

journal_title：Cancer research

authors： Shen A,Chen Y,Liu L,Huang Y,Chen H,Qi F,Lin J,Shen Z,Wu X,Wu M,Li Q,Qiu L,Yu N,Sferra TJ,Peng J

更新日期：2019-05-01 00:00:00

abstract：:Because chronic intestinal inflammation is a risk factor for colorectal cancer, we hypothesized that genetic variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with colon cancer susceptibility. Here, we report the association of 24 MBL2 single-nucleotide polymorphisms (SNP) and...

journal_title：Cancer research

authors： Zanetti KA,Haznadar M,Welsh JA,Robles AI,Ryan BM,McClary AC,Bowman ED,Goodman JE,Bernig T,Chanock SJ,Harris CC

更新日期：2012-03-15 00:00:00

abstract：:DNA of invasive ductal carcinomas from five women was analyzed for structural alterations in the purine nucleotides using gas chromatography-mass spectrometry with selected ion monitoring. The results were compared to those for a normal DNA control. The carcinoma DNA showed dramatically higher concentrations of the ba...

journal_title：Cancer research

authors： Malins DC,Haimanot R

更新日期：1991-10-01 00:00:00

abstract：:The relation of in vitro properties to tumorigenicity was studied using eight sublines of the human breast cancer cell line MCF-7. Four of the eight were tumorigenic in estrogen-treated nude mice. The sublines differed for each of the in vitro properties measured, and no property correlated perfectly with tumorigenici...

journal_title：Cancer research

authors： Butler WB,Berlinski PJ,Hillman RM,Kelsey WH,Toenniges MM

更新日期：1986-12-01 00:00:00

abstract：:The potential for enhancing antibody potency by increasing avidity was investigated using monoclonal IgG homodimers. Chemically linked dimers were made from a human-murine chimeric monoclonal IgG (ChiBR96) which strongly binds to a variety of breast, lung, ovary, and colon carcinomas. This monoclonal antibody is capab...

journal_title：Cancer research

authors： Wolff EA,Schreiber GJ,Cosand WL,Raff HV

更新日期：1993-06-01 00:00:00

abstract：:Inhibition of constitutive active signaling pathways, which are a characteristic phenomenon for many tumors, can be an effective therapeutic strategy. In contrast, oncogenic transcription factors, often activated by mutational events, are in general less amenable to small-molecule inhibition despite their obvious impo...

journal_title：Cancer research

authors： Amstutz R,Wachtel M,Troxler H,Kleinert P,Ebauer M,Haneke T,Oehler-Jänne C,Fabbro D,Niggli FK,Schäfer BW

更新日期：2008-05-15 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an important member of the TNF superfamily with great potential in cancer therapy. Luteolin is a dietary flavonoid commonly found in some medicinal plants. Here we found that pretreatment with a noncytotoxic concentration of luteolin significantl...

journal_title：Cancer research

authors： Shi RX,Ong CN,Shen HM

更新日期：2005-09-01 00:00:00

abstract：:Rat R2k rhabdomyosarcoma cells were transfected with the human H-ras oncogene, which resulted in increased resistance to cell kill in vitro by a single dose of 137Cs gamma-rays. A subline carrying one oncogene showed an increase in the quasi-threshold dose (Dq) from 0.88 to 1.48 Gy. Another subline containing six onco...

journal_title：Cancer research

authors： Hermens AF,Bentvelzen PA

更新日期：1992-06-01 00:00:00

abstract：:Ubiquitination and ubiquitin-like posttranslational modifications (PTM) regulate activity and stability of oncoproteins and tumor suppressors. This implicates PTMs as antineoplastic targets. One way to alter PTMs is to inhibit activity of deubiquitinases (DUB) that remove ubiquitin or ubiquitin-like proteins from subs...

journal_title：Cancer research

authors： Mustachio LM,Lu Y,Kawakami M,Roszik J,Freemantle SJ,Liu X,Dmitrovsky E

更新日期：2018-02-01 00:00:00

abstract：:Specific binding sites for prolactin (PRL) were present in membrane preparations from 7,12-dimethylbenz(a)-anthracene-induced rat mammary tumors. The specific binding of PRL was time and temperature dependent. A significant negative correlation was noted between administered doses of estrogen and the subsequent bindin...

journal_title：Cancer research

authors： Kledzik GS,Bradley CJ,Marshall S,Campbell GA,Meites J

更新日期：1976-09-01 00:00:00

abstract：:cis-Diammine(1,1-cyclobutanedicarboxylato)platinum (CBDCA) is a nonnephrotoxic but myelosuppressive analogue of cisplatin (DDP) with greatly reduced protein binding and greatly increased renal excretion. Thus, CBDCA might produce undue toxicity in patients with decreased renal function. Twenty-two patients [14 females...

journal_title：Cancer research

authors： Egorin MJ,Van Echo DA,Tipping SJ,Olman EA,Whitacre MY,Thompson BW,Aisner J

更新日期：1984-11-01 00:00:00

abstract：:Kras is a decisive oncogene in pancreatic ductal adenocarcinoma (PDAC). PIN1 is a key effector involved in the Kras/ERK axis, synergistically mediating various cellular events. However, the underlying mechanism by which PIN1 promotes the development of PDAC remains unclear. Here we sought to elucidate the effect of PI...

journal_title：Cancer research

authors： Liang C,Shi S,Liu M,Qin Y,Meng Q,Hua J,Ji S,Zhang Y,Yang J,Xu J,Ni Q,Li M,Yu X

更新日期：2019-01-01 00:00:00

abstract：:Immunohistochemical staining for the p53 protein was performed in 107 snap frozen primary endometrial adenocarcinomas and 15 benign uterine tissues using monoclonal antibody PAb1801. No staining was seen in benign samples, whereas intense nuclear staining of cancer cells consistent with overexpression of the p53 prote...

journal_title：Cancer research

authors： Kohler MF,Berchuck A,Davidoff AM,Humphrey PA,Dodge RK,Iglehart JD,Soper JT,Clarke-Pearson DL,Bast RC Jr,Marks JR

更新日期：1992-03-15 00:00:00

abstract：:We studied the clinical and karyotypic features of 50 patients with acute lymphoblastic leukemia, including 33 American and 17 Japanese patients, at two institutions. Clonal chromosome abnormalities were found in 39 of the 50 patients (78%) at diagnosis. Eleven patients had diploidy (N patients). Among the 39 aneuploi...

journal_title：Cancer research

authors： Kaneko Y,Rowley JD,Variakojis D,Chilcote RR,Check I,Sakurai M

更新日期：1982-07-01 00:00:00

abstract：:Virtually all patients with chronic myelogenous leukemia (CML) express an aberrant protein (p210 Bcr-Abl) that contains NH2-terminal sequences from Bcr fused to COOH-terminal sequences from Abl. In a yeast two-hybrid screen, we have identified TSG101 as a binding partner for Bcr. Because TSG101 is a subunit of the mam...

journal_title：Cancer research

authors： Olabisi OO,Mahon GM,Kostenko EV,Liu Z,Ozer HL,Whitehead IP

更新日期：2006-06-15 00:00:00

abstract：:We have studied the lipid composition and the acyl group composition, transport, and metabolism of doxorubicin-sensitive and -resistant rat glioblastoma cells in monolayer cultures (C6 clone). No difference in lipid composition was evidenced; the acyl group composition was, in contrast, highly modified in resistant ce...

journal_title：Cancer research

authors： Vrignaud P,Montaudon D,Londos-Gagliardi D,Robert J

更新日期：1986-07-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men. Advanced prostate cancer spreading beyond the gland is incurable. Identifying factors that regulate the spread of tumor into the regional nodes and distant sites would guide the development of novel diagnostic, prognostic, and therapeutic targets. The aim of our study ...

journal_title：Cancer research

authors： Xia G,Kumar SR,Masood R,Zhu S,Reddy R,Krasnoperov V,Quinn DI,Henshall SM,Sutherland RL,Pinski JK,Daneshmand S,Buscarini M,Stein JP,Zhong C,Broek D,Roy-Burman P,Gill PS

更新日期：2005-06-01 00:00:00

abstract：:The oxidation of the bladder carcinogen 2-naphthylamine (2-NA) by prostaglandin H synthase (PHS) in vitro was examined. Oxygen uptake studies of 2-NA oxidation in the presence of glutathione, as well as extensive product analysis data, are consistent with a one-electron mechanism of 2-NA oxidation by PHS. The formatio...

journal_title：Cancer research

authors： Boyd JA,Eling TE

更新日期：1987-08-01 00:00:00

abstract：:A major objective of the emerging field of exercise-oncology research is to determine the efficacy of, and biological mechanisms by which, aerobic exercise affects cancer incidence, progression, and/or metastasis. There is a strong inverse association between self-reported exercise and the primary incidence of several...

journal_title：Cancer research

authors： Ashcraft KA,Peace RM,Betof AS,Dewhirst MW,Jones LW

更新日期：2016-07-15 00:00:00