Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial.

abstract：:Fibrin forms the cohesive network of hemostatic plugs and thrombi, and it also provides the temporary matrix for initial support of healing and revascularization. Because cell proliferation is needed for revascularization after vessel injury, we have characterized structural requirements of fibrin needed to support ce...

journal_title：Blood

authors： Sporn LA,Bunce LA,Francis CW

更新日期：1995-09-01 00:00:00

abstract：:Recombinant human interleukin-6 (IL-6) has previously been shown to increase platelet counts in normal and sublethally irradiated mice, dogs, and primates. To assess its tolerance and efficacy in clinical use, we performed a randomized phase Ib study in patients with ovarian carcinoma. IL-6 was administered during an ...

journal_title：Blood

authors： D'Hondt V,Humblet Y,Guillaume T,Baatout S,Chatelain C,Berlière M,Longueville J,Feyens AM,de Greve J,Van Oosterom A

更新日期：1995-05-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) is considered a negative regulator of inflammation, as inhibition of STAT3 signaling enhances antitumor immunity. However, STAT3 activation is a key oncogenic pathway in natural killer (NK)-lineage large granular lymphomas, and we recently reported enhanced pr...

journal_title：Blood

authors： Zhu S,Phatarpekar PV,Denman CJ,Senyukov VV,Somanchi SS,Nguyen-Jackson HT,Mace EM,Freeman AF,Watowich SS,Orange JS,Holland SM,Lee DA

更新日期：2014-07-17 00:00:00

abstract：:The clinical use of intravenous immunoglobulin (IVIg) based on its immunomodulatory and anti-inflammatory potential remains an ongoing challenge. Fcgamma receptor-mediated effects of IVIg, although well elucidated in certain pathologies, cannot entirely account for its proven benefit in several autoimmune disorders me...

journal_title：Blood

authors： Ephrem A,Chamat S,Miquel C,Fisson S,Mouthon L,Caligiuri G,Delignat S,Elluru S,Bayry J,Lacroix-Desmazes S,Cohen JL,Salomon BL,Kazatchkine MD,Kaveri SV,Misra N

更新日期：2008-01-15 00:00:00

abstract：:Hematopoiesis is tightly controlled by transcription regulatory networks, but how and when specific transcription factors control lineage commitment are still largely unknown. Within the hematopoietic stem cell (Lin(-)Sca-1(+)c-Kit(+)) compartment these lineage-specific transcription factors are expressed at low level...

journal_title：Blood

authors： Wölfler A,Danen-van Oorschot AA,Haanstra JR,Valkhof M,Bodner C,Vroegindeweij E,van Strien P,Novak A,Cupedo T,Touw IP

更新日期：2010-11-18 00:00:00

abstract：:Although the rheologic behavior of sickle erythrocytes (SS cells) is highly dependent on oxygen tension (pO2) and temperature, very little data exist regarding the effects of deoxygenation and reoxygenation on the rheology of "individual" SS cells at body temperature. We have devised and assessed a new experiment syst...

journal_title：Blood

authors： Itoh T,Chien S,Usami S

更新日期：1992-04-15 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) is the most important cytokine involved in the promotion of myelofibrosis. Mechanisms leading to its local activation in the bone marrow environment remain unclear. As a recent study has highlighted the role of thrombospondin-1 (TSP-1) in platelet-derived TGF-β1 activation, we in...

journal_title：Blood

authors： Evrard S,Bluteau O,Tulliez M,Rameau P,Gonin P,Zetterberg E,Palmblad J,Bonnefoy A,Villeval JL,Vainchenker W,Giraudier S,Wagner-Ballon O

更新日期：2011-01-06 00:00:00

abstract：:The critical role of Janus kinase-2 (JAK2) in regulation of myelopoiesis was established 2 decades ago, but identification of mutations in the pseudokinase domain of JAK2 in myeloproliferative neoplasms (MPNs) and in other hematologic malignancies highlighted the role of JAK2 in human disease. These findings have revo...

journal_title：Blood

authors： Silvennoinen O,Hubbard SR

更新日期：2015-05-28 00:00:00

abstract：:The belief is widely held, on the basis of indirect evidence, that a substantial, even brief elevation of red cell Ca content must result in a marked shortening of circulatory survival. To test this notion directly, we exposed rabbit red cells in vitro to the ionophore A23187 and Ca so as to produce sustained uniform ...

journal_title：Blood

authors： Bookchin RM,Roth EF Jr,Lew VL

更新日期：1985-07-01 00:00:00

abstract：:In this issue of Blood, Kassebaum et al estimate that the global anemia prevalence in 2010 was 32.9%, resulting in 68.4 million years lived with disability (YLD). The results emphasize the important contribution made by anemia to the overall global burden of disease and should help focus attention and resources toward...

journal_title：Blood

authors： Pasricha SR

更新日期：2014-01-30 00:00:00

abstract：:The association of thrombosis and gestational morbidity with antiphospholipid antibodies is termed antiphospholipid syndrome (APS). Annexin 2 (A2) is a profibrinolytic endothelial cell surface receptor that binds plasminogen, its tissue activator (tPA), and beta(2)-glycoprotein I (beta2GPI), the main antigen for antip...

journal_title：Blood

authors： Cesarman-Maus G,Ríos-Luna NP,Deora AB,Huang B,Villa R,Cravioto Mdel C,Alarcón-Segovia D,Sánchez-Guerrero J,Hajjar KA

更新日期：2006-06-01 00:00:00

abstract：:Using Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) as a model, our aim has been to develop a molecular cytogenetic method of high resolution analysis for monitoring the frequency of cells with nonrandom chromosome rearrangements in the bone marrow of patients receiving treatment for hemato...

journal_title：Blood

authors： Seong DC,Kantarjian HM,Ro JY,Talpaz M,Xu J,Robinson JR,Deisseroth AB,Champlin RE,Siciliano MJ

更新日期：1995-09-15 00:00:00

abstract：:This study was undertaken to gain further insight into the severely impaired natural killer (NK) activity we and others have previously observed in patients with chronic lymphocytic leukemia (CLL). Normal individuals' NK cells are large granular lymphocytes (LGL) that (A) bind to and lyse NK-sensitive cells, including...

journal_title：Blood

authors： Kay NE,Zarling JM

更新日期：1984-02-01 00:00:00

abstract：:Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma is a distinct peripheral T-cell lymphoma, which closely resembles angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) and/or IBL, but is characterized by focal or sheet-like proliferation of immunoblasts and pale cells of T-cell nature. In this report,...

journal_title：Blood

authors： Tobinai K,Minato K,Ohtsu T,Mukai K,Kagami Y,Miwa M,Watanabe S,Shimoyama M

更新日期：1988-09-01 00:00:00

abstract：:Mutations in the Bcr-Abl kinase domain may cause, or contribute to, resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia patients. Recommendations aimed to rationalize the use of BCR-ABL mutation testing in chronic myeloid leukemia have been compiled by a panel of experts appointed by the Europe...

journal_title：Blood

authors： Soverini S,Hochhaus A,Nicolini FE,Gruber F,Lange T,Saglio G,Pane F,Müller MC,Ernst T,Rosti G,Porkka K,Baccarani M,Cross NC,Martinelli G

更新日期：2011-08-04 00:00:00

abstract：:In this issue of Blood, Baychelier et al identify a ligand for a major natural killer (NK) cell receptor that mediates natural cytotoxicity toward tumor cells, thus ending a search that lasted well over a decade. ...

journal_title：Blood

authors： Rajagopalan S,Long EO

更新日期：2013-10-24 00:00:00

abstract：:The expansion of follicular lymphomas (FLs) resembles, both morphologically and functionally, normal germinal center B-cell growth. The tumor cells proliferate in networks of follicular dendritic cells and are believed to be capable of somatic hypermutation and isotype switching. To investigate the relation between so...

journal_title：Blood

authors： Aarts WM,Bende RJ,Steenbergen EJ,Kluin PM,Ooms EC,Pals ST,van Noesel CJ

更新日期：2000-05-01 00:00:00

abstract：:Endothelial cells in vivo form the interface between the vascular and interstitial compartments and are strategically located to mediate vascular permeability and hemostasis. One mechanism endothelial cells use to maintain a nonthrombogenic surface is to polarize basement membrane constituents to the basolateral cell ...

journal_title：Blood

authors： Kowalczyk AP,Tulloh RH,McKeown-Longo PJ

更新日期：1990-06-15 00:00:00

abstract：:This study investigated the immunogenicity of Wilms tumor gene product 1 (WT1)-peptide vaccination in WT1-expressing acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients without curative treatment option. Vaccination consisted of granulocyte-macrophage colony-stimulating factor subcutaneously days ...

journal_title：Blood

authors： Keilholz U,Letsch A,Busse A,Asemissen AM,Bauer S,Blau IW,Hofmann WK,Uharek L,Thiel E,Scheibenbogen C

更新日期：2009-06-25 00:00:00

abstract：:Follicular dendritic cells (FDCs) in the lymphoid follicle (LF) are essential to the sequential processes of B-cell proliferation, selection, and differentiation. Although the importance of some cytokines in these processes has been pointed out, there is little information about the follicular localization of their re...

journal_title：Blood

authors： Yamada K,Yamakawa M,Imai Y,Tsukamoto M

更新日期：1997-12-15 00:00:00

abstract：:The SRC family kinases (SFKs) and the receptor tyrosine kinase c-Kit are activated in human acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells. Treatment with the SFK and c-KIT inhibitor dasatinib selectively inhibits human AML stem/p...

journal_title：Blood

authors： Dos Santos C,McDonald T,Ho YW,Liu H,Lin A,Forman SJ,Kuo YH,Bhatia R

更新日期：2013-09-12 00:00:00

abstract：:Complex molecular mechanisms control B-cell fate to become a memory or a plasma cell. Interleukin-24 (IL-24) is a class II family cytokine of poorly understood immune function that regulates the cell cycle. We previously observed that IL-24 is strongly expressed in leukemic memory-type B cells. Here we show that IL-24...

journal_title：Blood

authors： Maarof G,Bouchet-Delbos L,Gary-Gouy H,Durand-Gasselin I,Krzysiek R,Dalloul A

更新日期：2010-03-04 00:00:00

abstract：:The antiapoptotic proteins, Bcl-2 and Bcl-X(L), are expressed in most cases of acute myeloid leukemia (AML) and may contribute to drug resistance in AML. We tested the hypothesis that down-regulation of Bcl-2 alone by antisense oligodeoxynucleotides (Bcl-2-AS) induces apoptosis, even in the presence of other antiapopt...

journal_title：Blood

authors： Konopleva M,Tari AM,Estrov Z,Harris D,Xie Z,Zhao S,López-Berestein G,Andreeff M

更新日期：2000-06-15 00:00:00

abstract：:LMP-1, an Epstein-Barr viral (EBV) latency protein, is considered a viral oncogene because of its ability to transform rodent fibroblasts in vivo and render them tumorigenic in nude mice. In human B cells, EBV LMP-1 induces DNA synthesis and abrogates apoptosis. LMP-1 is expressed in EBV-transformed lymphoblastoid cel...

journal_title：Blood

authors： Kingma DW,Weiss WB,Jaffe ES,Kumar S,Frekko K,Raffeld M

更新日期：1996-07-01 00:00:00

abstract：:Hemoglobin E (HbE) β-thalassemia is the most common severe thalassemia syndrome across Asia, and millions of people are carriers. Clinical heterogeneity in HbE β-thalassemia is incompletely explained by genotype, and the interaction of phenotypic variation with hepcidin is unknown. The effect of thalassemia carriage o...

journal_title：Blood

authors： Jones E,Pasricha SR,Allen A,Evans P,Fisher CA,Wray K,Premawardhena A,Bandara D,Perera A,Webster C,Sturges P,Olivieri NF,St Pierre T,Armitage AE,Porter JB,Weatherall DJ,Drakesmith H

更新日期：2015-01-29 00:00:00

abstract：:Fibronectin is a major component of the extracellular matrix of adherent layers of human long-term marrow cultures where it may stabilize the extracellular matrix network and provide adhesion sites for primitive hemopoietic cells. This study was devised to analyze the role of adherent cell populations in fibronectin s...

journal_title：Blood

authors： Lerat H,Lissitzky JC,Singer JW,Keating A,Herve P,Charbord P

更新日期：1993-09-01 00:00:00

abstract：:Patients with disseminated follicular non-Hodgkin's lymphoma (NHL) are only occasionally cured with standard chemotherapy regimens. Although most of these tumors are initially responsive to chemotherapy, in 40% to 70% of patients the lymphoma will eventually transform to an NHL of higher grade malignancy and a poorer ...

journal_title：Blood

authors： Schouten HC,Bierman PJ,Vaughan WP,Kessinger A,Vose JM,Weisenburger DD,Armitage JO

更新日期：1989-11-15 00:00:00

abstract：:The regulation of plasmin generation on cell surfaces is of critical importance in the control of vascular homeostasis. Cell-derived microparticles participate in the dissemination of biological activities. However, their capacity to promote plasmin generation has not been documented. In this study, we show that endot...

journal_title：Blood

authors： Lacroix R,Sabatier F,Mialhe A,Basire A,Pannell R,Borghi H,Robert S,Lamy E,Plawinski L,Camoin-Jau L,Gurewich V,Angles-Cano E,Dignat-George F

更新日期：2007-10-01 00:00:00

abstract：:Over the past 2 decades considerable evidence has accumulated on the association between hepatitis C virus (HCV) and hepatitis B virus (HBV) and several hematologic malignancies, most notably B-cell non-Hodgkin lymphoma (NHL). In this review we summarize this evidence, address possible mechanisms whereby hepatitis vir...

journal_title：Blood

authors： Marcucci F,Mele A

更新日期：2011-02-10 00:00:00

abstract：:To determine whether a prior history of hepatosplenic candidiasis resulted in increased Candida-associated morbidity and mortality after marrow transplant, 15 consecutive patients with biopsy-proven hepatosplenic candidiasis were observed prospectively. All patients received amphotericin B before transplant. Amphoteri...

journal_title：Blood

authors： Bjerke JW,Meyers JD,Bowden RA

更新日期：1994-10-15 00:00:00