Abstract:
:The CBP/p300 family of proteins comprises related acetyltransferases that coactivate signal-responsive transcription. Recent evidence suggests that p300/CBP may also interact directly with complexes that mediate different aspects of DNA metabolism such as replication and repair. In this report, we show that loss of dCBP in Drosophila cells and eye discs results in a defect in the cell cycle arrest induced by stalled DNA replication. We show that dCBP and the checkpoint kinase Mei-41 can be found together in a complex and, furthermore, that dCBP has a genetic interaction with mei-41 in the response to stalled DNA replication. These observations suggest a broader role for the p300/CBP acetyltransferases in the modulation of chromatin structure and function during DNA metabolic events as well as for transcription.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Smolik S,Jones Kdoi
10.1128/MCB.01283-06subject
Has Abstractpub_date
2007-01-01 00:00:00pages
135-46issue
1eissn
0270-7306issn
1098-5549pii
MCB.01283-06journal_volume
27pub_type
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