Abstract:
OBJECTIVE:To present a decision support system for optimising mechanical ventilation in patients residing in the intensive care unit. METHODS:Mathematical models of oxygen transport, carbon dioxide transport and lung mechanics are combined with penalty functions describing clinical preference toward the goals and side-effects of mechanical ventilation in a decision theoretic approach. Penalties are quantified for risk of lung barotrauma, acidosis or alkalosis, oxygen toxicity or absorption atelectasis, and hypoxaemia. RESULTS:The system is presented with an example of its use in a post-surgical patient. The mathematical models describe the patient's data, and the system suggests an optimal ventilator strategy in line with clinical practice. CONCLUSIONS:The system illustrates how mathematical models combined with decision theory can aid in the difficult compromises necessary when deciding on ventilator settings.
journal_name
J Clin Monit Computjournal_title
Journal of clinical monitoring and computingauthors
Rees SE,Allerød C,Murley D,Zhao Y,Smith BW,Kjaergaard S,Thorgaard P,Andreassen Sdoi
10.1007/s10877-006-9049-5subject
Has Abstractpub_date
2006-12-01 00:00:00pages
421-9issue
6eissn
1387-1307issn
1573-2614journal_volume
20pub_type
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章
doi:10.1007/s10877-015-9727-2
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pub_type: 杂志文章,评审
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journal_title:Journal of clinical monitoring and computing
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pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-12-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章
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更新日期:2017-10-01 00:00:00
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章
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更新日期:1999-02-01 00:00:00
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章,多中心研究
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更新日期:2008-04-01 00:00:00
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00