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Epithelial cells from normal human endometrium express a tumor-associated glycoprotein (TAG-72) epitope in vitro.

Abstract：

:Monoclonal antibody B72.3 identifies a tumor-associated glycoprotein (TAG-72) epitope derived from a human breast carcinoma metastasis. Recently, expression of this epitope was noted in normal endometrium during the secretory, but not proliferative, menstrual interval. In light of known hormonal control of normal endometrial growth and differentiation, we investigated in vitro expression of TAG-72 epitope in purified endometrial epithelium cultured under serum-free conditions on Matrigel biomatrix. Cells from secretory endometrium exhibited homogeneous tumor-associated glycoprotein 72 epitope expression. Unexpectedly, epithelium from the proliferative interval developed expression after 5 to 6 days of culture. Epithelial cells from both intervals maintained expression over 12 days of culture without exogenous estradiol and progesterone. Spontaneous, uniform expression of tumor-associated glycoprotein 72 epitope by normal endometrial epithelial cells in vitro is in marked contrast to the cyclic, heterogeneous expression observed in vivo. Such expression also differs from published in vitro observations of cancer cell lines that express this epitope.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Osteen KG,Anderson TL,Hargrove JT,Hill GA,Gorstein F

doi

10.1016/0002-9378(90)91179-g

subject

Has Abstract

pub_date

1990-08-01 00:00:00

pages

479-84

issue

2

eissn

0002-9378

issn

1097-6868

pii

0002-9378(90)91179-G

journal_volume

163

pub_type

杂志文章

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