Pulmonary adenocarcinoma: the expanding spectrum of histologic variants.

Abstract:

:Pulmonary adenocarcinoma is one of the most common types of lung cancer. Traditionally, adenocarcinomas have been divided based on their degree of resemblance to their parent tissues into 3 histopathologic types: well, moderately, and poorly differentiated. In the majority of cases, this schema is sufficient to categorize these lung tumors. However, there is a considerable group of tumors in which the histology is not that of the classic gland-forming neoplasm. Thus, although the terminology of adenocarcinoma is applied in such cases, the histopathologic features are different from those of the more conventional variants. The current review addresses these unusual variants and the importance of recognizing and properly categorizing them to avoid unnecessary additional workup or possible misdiagnosis.

journal_name

Arch Pathol Lab Med

authors

Moran CA

doi

10.1043/1543-2165(2006)130[958:PATESO]2.0.CO;2

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

958-62

issue

7

eissn

0003-9985

issn

1543-2165

pii

RA-6-0062

journal_volume

130

pub_type

杂志文章,评审
  • Primary angiitis of the central nervous system associated with Hodgkin's disease.

    abstract::An unusual case of primary angiitis of the central nervous system associated with Hodgkin's disease in a 55-year-old-man is reported. After a 10-month history of acute transverse myelitis, the patient was diagnosed as having nodular sclerosing-type Hodgkin's disease involving the retroperitoneal lymph nodes. The patie...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Yuen RW,Johnson PC

    更新日期:1996-06-01 00:00:00

  • Mixed tumors of the salivary glands. Growth pattern and recurrence.

    abstract::In 112 patients with mixed tumors of the salivary glands, 94 tumors were located in parotid glands, 11 in submandibular salivary glands, and 7 in monor palatal salivary glands. Capsular ingrowth, a characteristic growth pattern, may explain the frequency of multilobulation and capsular defects in these tumors, particu...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Naeim F,Forsberg MI,Waisman J,Coulson WF

    更新日期:1976-05-01 00:00:00

  • A unique, complex variant philadelphia chromosome translocation in a patient with typical chronic myelogenous leukemia.

    abstract::The Philadelphia (Ph) chromosome [der(22) t(9;22)(q34;q11)] is the characteristic chromosomal abnormality found in chronic myelogenous leukemia (CML). This chromosome has been reported in patients with other chromosomal abnormalities. In this study, we describe a patient with hematologically typical chronic-phase CML ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2001)125<0437:AUCVPC>2.0.CO;2

    authors: Oudat R,Khan Z,Glassman AB

    更新日期:2001-03-01 00:00:00

  • Hyperchromatic crowded groups in cervical cytology--differing appearances and interpretations in conventional and ThinPrep preparations: a study from the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology.

    abstract:CONTEXT:The practice of gynecologic cytology requires that high-grade squamous intraepithelial lesion (HSIL) be precisely recognized. In this regard, hyperchromatic crowded groups are known to be difficult to classify in conventional gynecologic cytology, but whether this is true in ThinPrep specimens is uncertain. OB...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2006)130[332:HCGICC]2.0.CO;2

    authors: Renshaw AA,Mody DR,Wang E,Haja J,Colgan TJ,Cytopathology Resource Committee, College of American Pathologists.

    更新日期:2006-03-01 00:00:00

  • Gastric toxoplasmosis in a patient with acquired immunodeficiency syndrome. A case report and review of the literature.

    abstract::Toxoplasmosis is a common opportunistic pathogen in patients with acquired immunodeficiency syndrome (AIDS). It usually presents with ocular, central nervous system, or pulmonary disease. Gastric toxoplasmosis is uncommon in AIDS patients, especially in the absence of central nervous system manifestations. In the few ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165(2003)127<732:GTIAPW>2.0.CO;2

    authors: Ganji M,Tan A,Maitar MI,Weldon-Linne CM,Weisenberg E,Rhone DP

    更新日期:2003-06-01 00:00:00

  • ras Gene mutations and expression of Ras signal transduction mediators in gastric adenocarcinomas.

    abstract:OBJECTIVE:To investigate ras gene alteration in human gastric adenocarcinomas and its potential relationship to ras signal transduction mediators. DESIGN:Genomic DNA from 104 gastric tumors were analyzed by sequencing of polymerase chain reaction-amplified products for the presence of ras mutations. All the samples we...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2002)126<1096:RGMAEO>2.0.CO;2

    authors: Yoo J,Park SY,Robinson RA,Kang SJ,Ahn WS,Kang CS

    更新日期:2002-09-01 00:00:00

  • Pathophysiology of heparin-induced thrombocytopenia. Clinical and diagnostic implications--a review.

    abstract:OBJECTIVE:This review of heparin-induced thrombocytopenia (HIT), the most frequent and dangerous side effect of heparin exposure, covers the epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment of this disease syndrome. DATA SOURCES AND STUDY SELECTION:Current consensus of opinion is given ba...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/0003-9985(2000)124<1657:POHIT>2.0.CO;2

    authors: Fabris F,Ahmad S,Cella G,Jeske WP,Walenga JM,Fareed J

    更新日期:2000-11-01 00:00:00

  • Osteosarcoma of the testis.

    abstract::We studied a unique case of osteosarcoma of the testis. The tumor either originated from indifferent mesenchymal cells, or it represents a one-sided monomorphic development of a teratoma. ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Mathew T,Prabhakaran K

    更新日期:1981-01-01 00:00:00

  • Interpretation and Utility of Drug of Abuse Screening Immunoassays: Insights From Laboratory Drug Testing Proficiency Surveys.

    abstract:CONTEXT.—:Urine drug testing is frequently ordered by health care providers. Immunoassays are widely used for drug testing, yet have potential limitations, including variable cross-reactivity. The last decade has seen worsening of a prescription drug abuse epidemic. OBJECTIVE.—:To use data from a College of American P...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2018-0562-CP

    authors: Krasowski MD,McMillin GA,Melanson SEF,Dizon A,Magnani B,Snozek CLH

    更新日期:2020-02-01 00:00:00

  • Light microscopy techniques for the demonstration of silicone gel.

    abstract::Because of the difficulty in identifying silicone gel in histologic and cytologic specimens by means of conventional light microscopy, we investigated alternative light microscopy techniques, as well as specimen staining and preparation. Specimens from six periprosthetic capsules, one silicone granuloma specimen, and ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Raso DS,Greene WB,Vesely JJ,Willingham MC

    更新日期:1994-10-01 00:00:00

  • MUC1 gene-derived glycoprotein assays for monitoring breast cancer (CA 15-3, CA 27.29, BR): are they measuring the same antigen?

    abstract:CONTEXT:There are 2 general types of assays measuring MUC1 gene-derived glycoprotein: assays for cancer antigen (CA) 15-3, which are sandwich assays, and assays for CA 27.29, which are competitive assays. These 2 types of assays measure slightly different parts of this tandem-repeat molecule. Across-method assay differ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2004)128<1131:MGGAFM>2.0.CO;2

    authors: Klee GG,Schreiber WE

    更新日期:2004-10-01 00:00:00

  • Structure and function of small airways in health and disease.

    abstract::During the last two decades, great strides have been made in our understanding of the functional aspects of airflow in the periphery of the lung. It seems that the small airways are the important site of obstruction in a variety of chronic respiratory disorders associated with airflow obstruction. This review deals wi...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Ranga V,Kleinerman J

    更新日期:1978-12-01 00:00:00

  • Perineural and intraneural inflammatory infiltrates in the intestines of patients with systemic connective-tissue disease.

    abstract::Intestinal biopsy specimens were examined from patients with connective-tissue diseases who had symptoms that were thought to represent early gastrointestinal involvement by the disease. Specimens from the small and large intestines contained eosinophils and mast cells, in close association with Meissner's and Auerbac...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: DeSchryver-Kecskemeti K,Clouse RE

    更新日期:1989-04-01 00:00:00

  • Large histiocytes in the choroid of leukemic patients.

    abstract::We identified large histiocytes as a prominent feature in the choroid of eyes obtained at autopsy in seven of nine patients who died of leukemia. The eyes of four of the seven patients affected had leukemic choroidal infiltrates, and a majority had similar-appearing histiocytes identified in spleen or bone marrow. The...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Campbell RA,Bouldin TW,Peiffer RL

    更新日期:1990-02-01 00:00:00

  • Xanthomatous bronchiolitis obliterans with cholesterol pneumonia.

    abstract::Reported is an instance of bronchiolitis obliterans due to the accumulation of lipid-laden cells within bronchiolar walls and lumina. The bronchiolar lining had extensive squamous and goblet cell metaplasia with focal ulceration. Scattered foci of cholesterol pneumonia, composed of acicular crystals with an associated...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Heffelfinger SC,Weilbaecher DG,Lawrence EC,Johnson EH,Greenberg SD

    更新日期:1988-06-01 00:00:00

  • CDX2 is a useful marker of intestinal-type differentiation: a tissue microarray-based study of 629 tumors from various sites.

    abstract:CONTEXT:CDX2, a critical nuclear transcription factor for intestinal development, is expressed in intestinal epithelium and adenocarcinomas. OBJECTIVES:To determine if CDX2 is a useful marker for intestinal-type differentiation and to correlate tumor histology with CDX2 staining in colorectal adenocarcinomas. DESIGN:...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2005)129[1100:CIAUMO]2.0.CO;2

    authors: De Lott LB,Morrison C,Suster S,Cohn DE,Frankel WL

    更新日期:2005-09-01 00:00:00

  • Abstract/Case Study Review Committee for the College of American Pathologists 2016 Annual Meeting (CAP16).

    abstract::The Archives of Pathology & Laboratory Medicine acknowledges the following individuals for volunteering to review abstract and case study submissions for the CAP16 meeting. ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2016-0240-AB

    authors:

    更新日期:2016-09-01 00:00:00

  • Kikuchi-Fujimoto Disease: A Review.

    abstract::Kikuchi-Fujimoto disease (KFD) is a rare entity characterized by subacute necrotizing lymphadenopathy and frequently associated with fever. Young adults of Asian ancestry are most commonly affected, but it has been reported worldwide. Despite many studies in the literature, the cause of KFD remains uncertain. Histolog...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2018-0219-RA

    authors: Perry AM,Choi SM

    更新日期:2018-11-01 00:00:00

  • Low-grade myofibroblastic proliferations of the urinary bladder.

    abstract:CONTEXT:Myofibroblastic proliferations of the urinary bladder, which share some similarities with nodular fasciitis, were first reported in 1980. Since then, they have had several designations, the most frequently used being inflammatory myofibroblastic tumor. Based on both histopathologic and prognostic grounds, some ...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2012-0326-RA

    authors: Alquati S,Gira FA,Bartoli V,Contini S,Corradi D

    更新日期:2013-08-01 00:00:00

  • Primary hepatic marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type in a patient with primary biliary cirrhosis.

    abstract::Primary lymphoma of the liver is rare. Recently, marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type have been described in the liver. Most of these cases occurred without known underlying liver disease, while others were seen in patients with chronic hepatitis. A case of primary hepatic MA...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2000)124<0604:PHMZBC>2.0.CO;2

    authors: Ye MQ,Suriawinata A,Black C,Min AD,Strauchen J,Thung SN

    更新日期:2000-04-01 00:00:00

  • Achieving quality reproducible results and maintaining compliance in molecular diagnostic testing of human papillomavirus.

    abstract::Laboratories contemplating either the addition of new molecular tests or modifying methods approved by the Food and Drug Administration for human papillomavirus testing should be aware of a variety of procedural, performance, and regulatory issues surrounding such activity. Diagnostic medical laboratory testing in the...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165(2003)127<978:AQRRAM>2.0.CO;2

    authors: Seabrook JM,Hubbard RA

    更新日期:2003-08-01 00:00:00

  • An in-depth look at Leydig cell tumor of the testis.

    abstract::Leydig cell tumor (LCT) is a rare tumor of the male testicular interstitium. This article provides an overview of the major pathologic manifestations of LCT of the testis; patient characteristics; clinical, radiologic, and laboratory features; prognosis; and management. LCTs of the testis are frequently hormonally act...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1043/1543-2165(2007)131[311:AILALC]2.0.CO;2

    authors: Al-Agha OM,Axiotis CA

    更新日期:2007-02-01 00:00:00

  • Endocrine manifestations of von Hippel-Lindau disease.

    abstract::von Hippel-Lindau (VHL) disease is an autosomal dominant disorder caused by heterozygous mutations in the VHL tumor suppressor gene that is characterized by the occurrence of multiple endocrine and nonendocrine lesions. This review focuses on the endocrine manifestations of VHL disease. Pancreatic neuroendocrine proli...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.5858/arpa.2013-0520-RS

    authors: Cassol C,Mete O

    更新日期:2015-02-01 00:00:00

  • Performance in Measurement of Serum Cystatin C by Laboratories Participating in the College of American Pathologists 2014 CYS Survey.

    abstract:CONTEXT:Cystatin C is becoming an increasingly popular biomarker for estimating glomerular filtration rate, and accurate measurements of cystatin C concentrations are necessary for accurate estimates of glomerular filtration rate. OBJECTIVE:To assess the accuracy of cystatin C concentration measurements in laboratorie...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.5858/arpa.2014-0427-CP

    authors: Eckfeldt JH,Karger AB,Miller WG,Rynders GP,Inker LA

    更新日期:2015-07-01 00:00:00

  • Experimental Staphylococcus epidermidis endocarditis in rabbit model.

    abstract::To study the natural course of catheter-induced endocarditis secondarily infected with Staphylococcus epidermidis, 29 rabbits had catheters introduced surgically through the carotid artery to the aortic valve. Forty-eight hours later the catheters were removed from five rabbits. The rabbits were inoculated intravenous...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Shamsuddin D,Tuazon CU,Miller H,Shamsuddin AK,Friedman D

    更新日期:1983-03-01 00:00:00

  • The value of CD64 expression in distinguishing acute myeloid leukemia with monocytic differentiation from other subtypes of acute myeloid leukemia: a flow cytometric analysis of 64 cases.

    abstract:CONTEXT:Flow cytometric immunophenotyping is a useful ancillary tool in the diagnosis and subclassification of acute myeloid leukemias (AMLs). A recent study concluded that CD64 is sensitive and specific for distinguishing AMLs with a monocytic component (ie, AML M4 and AML M5) from other AML subtypes. However, in that...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/1543-2165(2007)131[748:TVOCEI]2.0.CO;2

    authors: Dunphy CH,Tang W

    更新日期:2007-05-01 00:00:00

  • Survey of serum enzyme analyses. Human tissues as a source of enzymes.

    abstract::The College of American Pathologists' enzyme survey permits the evaluation of the quality of enzyme analyses in clinical laboratories. Animal source enzymes for lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, and creatine kinase are satisfactory as supplements for enzyme survey serum, sinc...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Lott JA,Tholen DW,Massion CG

    更新日期:1984-12-01 00:00:00

  • Primitive neuroectodermal tumor of the lung.

    abstract::Primitive neuroectodermal tumors occur most frequently in bone and soft tissue but have been reported in other locations. Primary lung primitive neuroectodermal tumors without pleural or chest wall involvement are extremely rare. We present a case with immunohistochemical and ultrastructural studies and follow-up of t...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(2001)125<0397:PNTOTL>2.0.CO;2

    authors: Kahn AG,Avagnina A,Nazar J,Elsner B

    更新日期:2001-03-01 00:00:00

  • Metanephric adenoma-like tumors of the kidney: report of 3 malignancies with emphasis on discriminating features.

    abstract:BACKGROUND:Metanephric adenoma is a very rare benign renal tumor; only 80 well-documented cases have been reported to date. We have seen several renal tumors that were originally incorrectly diagnosed as metanephric adenoma. DESIGN:We present 3 unusual renal tumors (2 primary and 1 metastatic), each of which illustrat...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:10.1043/0003-9985(1999)123<0415:MALTOT>2.0.CO;2

    authors: Pins MR,Jones EC,Martul EV,Kamat BR,Umlas J,Renshaw AA

    更新日期:1999-05-01 00:00:00

  • Receiver operating characteristic curves for analysis of the results of cervicovaginal smears. A useful quality improvement tool.

    abstract:OBJECTIVES:To assess the value of receiver operating characteristic curves (ROCs) as a tool for improvement in the evaluation of cervicovaginal smear results. DESIGN:We reviewed the results of cervicovaginal smear interpretation for 1 year by 10 different cytopathologists working in the same laboratory (total number o...

    journal_title:Archives of pathology & laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Renshaw AA,Dean BR,Cibas ES

    更新日期:1997-09-01 00:00:00