Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats.

abstract：OBJECTIVE:This was the first proof of principle clinical trial assessing the efficacy and safety of rufinamide as adjunctive therapy in epileptic patients. The pharmacokinetic (PK) profile of rufinamide was also determined. METHODS:Fifty patients with diagnoses of partial or primary generalized tonic-clonic seizures w...

journal_title：Epilepsy research

authors： Pålhagen S,Canger R,Henriksen O,van Parys JA,Rivière ME,Karolchyk MA

更新日期：2001-02-01 00:00:00

abstract：:This study was planned so as to evaluate whether magnetic field exposure has any significant effect on the pentylenetetrazol (PTZ)-induced seizures. Mice were exposed to 50 Hz, 2 G (0.2 mT) magnetic field in glass cages for 1 h. Sham exposure was produced by turning off the current while the animals were in the same e...

journal_title：Epilepsy research

authors： Keskil IS,Keskil ZA,Canseven AG,Seyhan N

更新日期：2001-04-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to determine the histological effects of valproic acid (VPA) on the penis in prepubertal rats. METHODS:Twelve male Wistar rats (21-24 days old) were divided equally into 2 experimental groups, and given tap water (control group) or 300mg/kg/day VPA via gavage for 30 days. After t...

journal_title：Epilepsy research

authors： Kutlu O,Cansu A,Karagüzel E,Gürgen SG,Koç O,Gür M,Ozgür GK

更新日期：2012-05-01 00:00:00

abstract：:The ketogenic diet (KD) increased the expression of calbindin-D(28k) (CB) in the interneurons of the hippocampus compared with the normal diet (ND)-fed mice. Also, 2 days after kainic acid (KA) administration, numerous CB-expressing astrocytes were found in the KD-fed mice compared with those of the ND-fed mice. These...

journal_title：Epilepsy research

authors： Noh HS,Kang SS,Kim DW,Kim YH,Park CH,Han JY,Cho GJ,Choi WS

更新日期：2005-07-01 00:00:00

abstract：:Biochemical studies have indicated that norepinephrine is present in lower levels in certain brain regions of genetically epilepsy-prone rats (GEPR-9s) as compared to non-epileptic Sprague-Dawley (SD) rats. In this study, the immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthesizing enzyme f...

journal_title：Epilepsy research

authors： Lauterborn JC,Ribak CE

更新日期：1989-11-01 00:00:00

abstract：:Understanding the relationship between seizure frequency, seizure type and scores obtained from quality of life (QOL) measures is important if the incorporation of QOL measures into epilepsy clinical trials is to become standard practice. There is also a need to consider cross-cultural differences obtained from QOL me...

journal_title：Epilepsy research

authors： Baker GA,Gagnon D,McNulty P

更新日期：1998-05-01 00:00:00

abstract：:The present study used Nissl stains and glutamate decarboxylase immunoreactivity (GAD-IR) to quantify the acute and chronic toxicity of kainic acid (KA) on focal and remote hippocampal principal neurons (i.e., pyramidal and granule cells) and on putative inhibitory neurons (GAD-IR or GABAergic) following intrahippocam...

journal_title：Epilepsy research

authors： Davenport CJ,Brown WJ,Babb TL

更新日期：1990-01-01 00:00:00

abstract：:Levetiracetam is a novel antiepileptic drug with an unknown mechanism of action. To-date levetiracetam is not known to be associated with any clinically significant pharmacokinetic interaction. Similarly, levetiracetam has not been associated with any pharmacodynamic interactions. We present four patients with severe ...

journal_title：Epilepsy research

authors： Sisodiya SM,Sander JW,Patsalos PN

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:The present study aims to determine the initialization and propagation of typical absence seizures using magnetoencephalography (MEG). METHOD:Fourteen drug-naïve children with childhood absence epilepsy (CAE) were studied using a 275-Channel MEG system. The spectral signatures of epileptic activity were assess...

journal_title：Epilepsy research

authors： Miao A,Tang L,Xiang J,Guan Q,Ge H,Liu H,Wu T,Chen Q,Yang L,Lu X,Hu Z,Wang X

更新日期：2014-03-01 00:00:00

abstract：:Daily treatment of mice with diazepam leads to the development of tolerance to the anxiolytic and anticonvulsant effect of the benzodiazepine, while daily treatment with the proconvulsant benzodiazepine receptor inverse agonist FG 7142 produces sensitization to its effects in that seizures develop (chemical kindling)....

journal_title：Epilepsy research

authors： Löscher W,Stephens DN

更新日期：1988-07-01 00:00:00

abstract：:The effect and safety of loreclezole were evaluated during a long-term follow-up trial targeting higher plasma concentrations than those of the preceding controlled trial. The result is better than in the double-blind trial, in which loreclezole doses were administered to reach plasma concentrations of 1-2 mg/l and 6/...

journal_title：Epilepsy research

authors： Rentmeester T,Janssen A,Hulsman J,Scholtes F,van der Kleij B,Overweg J,Meijer J,de Beukelaar F

更新日期：1991-05-01 00:00:00

abstract：:The monoamine content in cerebral structures has been related to neuronal excitability and several approaches have been used to study this phenomenon during seizure vulnerability. In the present work, we have described the effects of serotonin (5-HT) depletion after the administration of 5,7-dihydroxytryptamine (5,7-D...

journal_title：Epilepsy research

authors： Trindade-Filho EM,de Castro-Neto EF,de A Carvalho R,Lima E,Scorza FA,Amado D,Naffah-Mazzacoratti Mda G,Cavalheiro EA

更新日期：2008-12-01 00:00:00

abstract：:Clinical practitioners have often observed in the course of their daily work that the pain thresholds of epileptic patients seem to differ from those of healthy subjects. These patients can suffer from quite severe traumatic lesions without apparently experiencing any pain. Since they are usually under treatment for e...

journal_title：Epilepsy research

authors： Guieu R,Mesdjian E,Roger J,Dano P,Pouget J,Serratrice G

更新日期：1992-06-01 00:00:00

abstract：:To investigate involvement of extrafocal regions in mesial temporal lobe epilepsy (MTLE), we retrospectively explored abnormalities in distribution of iomazenil (IMZ) activity by identifying interhemispheric asymmetry on IMZ-SPECT images of patients with MTLE. Fourteen MTLE patients in whom a good surgical outcome was...

journal_title：Epilepsy research

authors： Hosomi K,Kishima H,Oshino S,Hirata M,Tani N,Maruo T,Khoo HM,Shimosegawa E,Hatazawa J,Kato A,Yoshimine T

更新日期：2013-02-01 00:00:00

abstract：:Nonconvulsive status epilepticus (NCSE) is difficult to diagnose but is an important cause of cognitive impairment. Electroencephalogram (EEG) monitoring is required for diagnosis and treatment. Little is known regarding the stability of subclinical epileptiform discharges (SEDs) preceding NCSE nor what strategies may...

journal_title：Epilepsy research

authors： Licht EA,Fujikawa DG

更新日期：2002-09-01 00:00:00

abstract：:Mutations in GABRG2, which encodes the γ2 subunit of GABAA receptors, can cause both genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome. Most GABRG2 truncating mutations associated with Dravet syndrome result in premature termination codons (PTCs) and are stably translated into mutant proteins wit...

journal_title：Epilepsy research

authors： Ishii A,Kanaumi T,Sohda M,Misumi Y,Zhang B,Kakinuma N,Haga Y,Watanabe K,Takeda S,Okada M,Ueno S,Kaneko S,Takashima S,Hirose S

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:To evaluate if the duration of epilepsy influences MRI volumes of the hippocampus, amygdala, parahippocampal gyrus, entorhinal cortex and temporal pole of both hemispheres and epileptogenic hippocampus neuronal cell density and dentate gyrus granular cells distribution in patients with refractory mesial tempora...

journal_title：Epilepsy research

authors： Duarte JTC,Jardim AP,Comper SM,De Marchi LR,Gaça LB,Garcia MTFC,Sandim GB,Assunção-Leme IB,Carrete H Jr,Centeno RS,Lancellotti CLP,Jackowski AP,Cavalheiro EA,Guaranha MSB,Yacubian EMT

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Aphasic status epilepticus (ASE), although rare, may often remain underdiagnosed. We aimed to report the patients diagnosed with ASE and describe their clinical presentation, etiology, electrophysiological findings, neuroimaging, treatment options, and outcome. METHODS:We retrospectively analyzed a series of...

journal_title：Epilepsy research

authors： Azman F,Tezer FI,Saygi S

更新日期：2020-11-01 00:00:00

abstract：:We analyzed preoperative ictal SPECT results from 18 frontal lobe epilepsy patients who underwent epilepsy surgery (mean age 22.9 years). Seizure onset at implanted subdural electrodes was defined as the epileptic focus in 16 of 18 patients. In two additional patients, the resected area on postoperative magnetic reson...

journal_title：Epilepsy research

authors： Fukuda M,Masuda H,Honma J,Kameyama S,Tanaka R

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate whether there may be a correlation between the anatomical variants of Circle of Willis (CoW) and presence/laterality of mesial temporal sclerosis (MTS). METHODS:We retrospectively identified the CoW variants on Wada angiograms in 71 patients with pathologically proven...

journal_title：Epilepsy research

authors： Kuyumcu G,Byrne RW,Dawe RJ,Kocak M

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:To describe the use of a population pharmacokinetic (PopPK) model incorporating weight and ontogeny to identify effective clobazam (CLB) dosing for use in a clinical trial in pediatric patients with Dravet syndrome. METHODS:Pharmacokinetic data were combined from 3 CLB trials (OV-1012, OV-1017, and study 301...

journal_title：Epilepsy research

authors： Tolbert D,Chu HM,Ette EI

更新日期：2019-11-01 00:00:00

abstract：:Valproate (VPA) and vigabatrin (gamma-vinyl GABA, GVG) are two novel antiepileptic drugs with a presumed GABAergic mechanism of action. However, for VPA, this aspect has been extensively debated. The aim of the present study was to investigate whether treatment of cultured neurons with clinically relevant concentratio...

journal_title：Epilepsy research

authors： Gram L,Larsson OM,Johnsen AH,Schousboe A

更新日期：1988-03-01 00:00:00

abstract：:Single photon emission computed tomography (SPECT) is increasingly being used as an adjunctive technique in the localisation of epileptogenic foci prior to surgery. As yet, few studies have been undertaken to establish the clinical associations of areas of reduced cerebral perfusion. Sixty-three consecutive patients (...

journal_title：Epilepsy research

authors： Duncan S,Gillen G,Adams FG,Duncan R,Brodie MJ

更新日期：1992-10-01 00:00:00

abstract：:Although accumulating evidence indicates that the immunomodulatory medication thalidomide exerts anticonvulsant properties, the mechanisms underlying such effects of thalidomide are still unknown. Our previous preclinical study suggested that nitric oxide (NO) signaling may be involved in the anticonvulsant effects of...

journal_title：Epilepsy research

authors： Pourshadi N,Rahimi N,Ghasemi M,Faghir-Ghanesefat H,Sharifzadeh M,Dehpour AR

更新日期：2020-08-01 00:00:00

abstract：:In rats, the concurrent alternate elicitation of epileptiform activity in two forebrain structures can result in both the rapid production of severe seizures and the development of fully generalized seizures in one (dominant) site, while arresting the progress of seizure activity at intermediate stages in the other (s...

journal_title：Epilepsy research

authors： Teskey GC,Thiessen EJ,Gilbert TH

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:To study the extent and characteristics of dietary and herbal supplements use in a large cohort of adult patients with epilepsy. METHODS:This prospective study included 490 patients receiving care at a university epilepsy clinic. A number of variables, including demographics, characteristics of epilepsy and it...

journal_title：Epilepsy research

authors： Bosak M,Mołek P,Słowik A

更新日期：2019-10-01 00:00:00

abstract：:Multiple subpial transection (MST) is an effective surgical therapy for patients with intractable seizures whose epileptogenic lesions lie in the cortex and are unresectable. Morrell developed this procedure and reported clinical results obtained using it. However, only the disappearance of epileptiform discharges aft...

journal_title：Epilepsy research

authors： Sugiyama S,Fujii M,Ito H

更新日期：1995-05-01 00:00:00

abstract：:Uncomplicated childhood-onset epilepsy is associated with increased brain amyloid load at late middle age, but its possible association with Alzheimer-type neurodegenerative processes is unclear. After 50-year follow-up, 42 childhood onset epilepsy subjects and 45 matched controls were investigated with [18F]fluorodeo...

journal_title：Epilepsy research

authors： Joutsa J,Rinne JO,Karrasch M,Hermann B,Johansson J,Anttinen A,Eskola O,Helin S,Shinnar S,Sillanpää M,TACOE study group.

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:To clarify the clinical and neurophysiological profiles of fronto-parietal opercular epilepsy in which epileptic spikes are detected with magnetoencephalography (MEG) but not with scalp electroencephalography (EEG). METHODS:Four patients presented with epileptic spikes localized to the fronto-parietal opercu...

journal_title：Epilepsy research

authors： Kakisaka Y,Iwasaki M,Alexopoulos AV,Enatsu R,Jin K,Wang ZI,Mosher JC,Dubarry AS,Nair DR,Burgess RC

更新日期：2012-11-01 00:00:00

abstract：:Treating a patient with antiepileptic drugs (AEDs) may give rise to unexpected life-threatening adverse events. Despite extensive experimental and clinical testing to ensure safety, most AEDs on the market have been associated with cases of severe cutaneous reactions, serious hematological disorders, or hepatic failur...

journal_title：Epilepsy research

authors： Arroyo S,de la Morena A

更新日期：2001-11-01 00:00:00