Abstract:
:A number of frequently prescribed gastrointestinal drugs can cause movement disorders in children, as well as in adults. In our centre for paediatric neurology, we saw a 3-year-old girl with abnormal movements mostly of the legs with an inner restlessness (akathisia) while using cisapride. Another patient, a 17-year-old male, developed a hemiballism (a fierce movement of one arm and shoulder with a hurling appearance) while using ranitidine for gastric distress. In both children, the movement disorder disappeared after discontinuing the drug. The pathophysiological mechanisms of these drug-induced movement disorders might be related to the central function of histamine in the developing brain. These cases illustrate the importance of being alert for possible drug-induced events early in the process of diagnosing abnormal movement disorders.
journal_name
Neuropediatricsjournal_title
Neuropediatricsauthors
Elzinga-Huttenga J,Hekster Y,Bijl A,Rotteveel Jdoi
10.1055/s-2006-923981subject
Has Abstractpub_date
2006-04-01 00:00:00pages
102-6issue
2eissn
0174-304Xissn
1439-1899journal_volume
37pub_type
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