Type III effector proteins: doppelgangers of bacterial virulence.

Abstract:

:Bacterial pathogens have co-evolved with their hosts in their ongoing quest for advantage in the resulting interaction. These intimate associations have resulted in remarkable adaptations of prokaryotic virulence proteins and their eukaryotic molecular targets. An important strategy used by microbial pathogens of animals to manipulate host cellular functions is structural mimicry of eukaryotic proteins. Recent evidence demonstrates that plant pathogens also use structural mimicry of host factors as a virulence strategy. Nearly all virulence proteins from phytopathogenic bacteria have eluded functional annotation on the basis of primary amino-acid sequence. Recent efforts to determine their three-dimensional structures are, however, revealing important clues about the mechanisms of bacterial virulence in plants.

journal_name

Curr Opin Plant Biol

authors

Desveaux D,Singer AU,Dangl JL

doi

10.1016/j.pbi.2006.05.005

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

376-82

issue

4

eissn

1369-5266

issn

1879-0356

pii

S1369-5266(06)00078-1

journal_volume

9

pub_type

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