Abstract：
:In vivo exposure has become the gold standard treatment for specific phobia. The endogenous opioid system is one mechanism proposed to explain why exposure provides such quick and effective treatment for specific phobia. The effect of naltrexone on fear and avoidance behavior was investigated among 15 specific phobia participants who received exposure treatment. Participants were randomly assigned to receive naltrexone, placebo, or no drug prior to attending one-session exposure treatment. Mixed effects regression results revealed that across time, the naltrexone group tolerated significantly less time in the room with the feared animal (Behavioral Avoidance Index) as compared to the placebo and no drug groups. Phobic individuals assigned to the naltrexone group had significantly higher fear ratings across time in comparison to the placebo group. Results provide support for the endogenous opioid system as a potential underlying biological mechanism associated with behavioral changes during in vivo exposure.
journal_name
J Anxiety Disordjournal_title
Journal of anxiety disordersauthors
Kozak AT,Spates CR,McChargue DE,Bailey KC,Schneider KL,Liepman MRdoi
10.1016/j.janxdis.2006.03.011subject
Has Abstractpub_date
2007-01-01 00:00:00pages
142-52issue
1eissn
0887-6185issn
1873-7897pii
S0887-6185(06)00048-Xjournal_volume
21pub_type
杂志文章,随机对照试验abstract：:We compared post-traumatic stress disorder (PTSD) symptom severity and symptom cluster profiles in hospital emergency department (ED) medical staff (N=100) who experienced an emotionally distressing work event that presented either a direct threat to themselves or a witnessed threat to patients. The two groups display...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2008.01.013
更新日期：2008-12-01 00:00:00
abstract：:This paper presents a meta-analysis of studies examining prevalence of psychopathology among offspring of anxiety-disordered parents, with the purpose of determining overall risk among these offspring for developing anxiety and depressive disorders. Pooled odds ratios for these disorders among high-risk offspring, com...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章,meta分析
doi：10.1016/j.janxdis.2009.07.021
更新日期：2009-12-01 00:00:00
abstract：:Consistent with a risk reduction model of targeted prevention, the present investigation piloted and empirically evaluated the feasibility and short-term efficacy of a first-generation panic prevention program that targeted two malleable risk factors for panic development-anxiety sensitivity and daily cigarette smokin...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.janxdis.2008.01.005
更新日期：2008-10-01 00:00:00
abstract：:There is increasing evidence that adult attachment plays a role in the development and perseverance of symptoms of posttraumatic stress disorder (PTSD). This meta-analysis aims to synthesise this evidence and investigate the relationship between adult attachment styles and PTSD symptoms. A random-effects model was use...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.janxdis.2015.07.002
更新日期：2015-10-01 00:00:00
abstract：:Twenty patients with dental anxiety were investigated while seated in a dental chair in a dental clinic. Heart rate (HR), heart rate variability (HRV), and skin conductance level (SCL) were recorded while the patients were exposed to scenes of dental treatment as well as a Stroop attentional task. Results showed an at...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/s0887-6185(02)00178-0
更新日期：2003-01-01 00:00:00
abstract：:Social anxiety has been associated with biases in cognitive processing and deficits in social performances. Yet, it remains unclear if these variations may be partly attributable to deficits in fundamental social abilities: for example, social intelligence (SI). Using the Magdeburg Test of Social Intelligence (MTSI) a...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2011.01.001
更新日期：2011-05-01 00:00:00
abstract：:The aim of the study was to explore differential attention profiles, according to attention types, in sub-clinical obsessive-compulsive checkers compared to controls. To examine attention biases in obsessive-compulsive phenomena, we compared sub-clinical checkers to non-checkers on their recall and recognition perform...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2009.01.007
更新日期：2009-04-01 00:00:00
abstract：:This study examined the relative efficacy of intensive versus weekly cognitive-behavioral therapy (CBT) for adults with obsessive-compulsive disorder (OCD). Sixty-two adults with OCD received either 14 sessions of weekly (n=30) or intensive CBT (n=32; daily psychotherapy sessions) in a non-randomized format. Assessmen...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2007.12.001
更新日期：2008-10-01 00:00:00
abstract：:We examined posttraumatic stress symptom clusters associations with psychopathology and functional impairment in 899 Norwegian survivors of the 2004 South-East Asia tsunami six months post-disaster. Posttraumatic stress symptoms were assessed with the Impact of Event Scale-Revised (IES-R) with intrusion, avoidance, an...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2010.06.020
更新日期：2010-12-01 00:00:00
abstract：:Three experiments measured differences in responding between participants scoring either higher or lower on obsessive-compulsive trait measures. A Sidman avoidance procedure was employed in Experiment 1, in which participants were required to identify an avoidance response that postponed an aversive event, and noted t...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.janxdis.2013.05.002
更新日期：2014-03-01 00:00:00
abstract：:To better understand the development and exacerbation of late-life anxiety, we tested a risk model positing that trait negative affect (NA) characteristics would interact with cognitive functioning, thereby increasing some older adults' risk for increased anxiety symptoms. The moderator-mediator model consisted of mea...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2013.03.008
更新日期：2013-08-01 00:00:00
abstract：:Although the traditional conceptualization of psychopathy suggests that this construct is negatively associated with anxiety the literature has produced mixed findings. The present study examined the relationship between self-report measures of anxiety/fear and psychopathy assessed using the Psychopathy Checklist: You...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2006.11.008
更新日期：2007-01-01 00:00:00
abstract：:This study investigated associations between anxious and depressive symptoms in 7- and 9-year-olds and their judgements of intention. It asked children to judge how a protagonist (other judgement) and they themselves (self-judgement) would interpret the intention of a second character, where this intention was ambiguo...
journal_title：Journal of anxiety disorders
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0887-6185(03)00030-6
更新日期：2004-01-01 00:00:00
abstract：:The present experiment examines the effect of fear on efficiency of three attention networks: executive attention, orienting and alerting, in a healthy female sample. International Affective Picture System (IAPS) images were used to elicit both a fear response and a non-emotional response in 100 participants. During t...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2009.08.005
更新日期：2010-01-01 00:00:00
abstract：:The Veteran's Health Administration (VHA) has launched a large-scale initiative to promote prolonged exposure (PE) therapy, an evidence-based treatment for PTSD. While existing randomized controlled trials (RCTs) unambiguously support the efficacy of PE in civilian and some military populations, there is a need to bet...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2010.11.002
更新日期：2011-04-01 00:00:00
abstract：:The present study examined (a) whether sleep related problems (SRPs) improved following cognitive-behavioral therapy (CBT) for youth with anxiety disorders, (b) whether variables that may link anxiety and SRPs (e.g., pre-sleep arousal, family accommodation, sleep hygiene) changed during treatment, and (c) whether such...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2015.11.006
更新日期：2016-01-01 00:00:00
abstract：:Empirical research has demonstrated that the Anxiety Sensitivity Index (ASI) contains three separable factors and that ASI total scores are useful in predicting response to physiological challenge procedures. Little is known, however, of the predictive capability of the ASI factors. This study investigated the utility...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/s0887-6185(01)00061-5
更新日期：2001-05-01 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) is a highly prevalent, often chronic and disabling psychiatric disorder that is associated with significant adverse health and life consequences. Although several evidence-based treatments (EBTs), including Prolonged Exposure therapy (PE), have been found effective and efficacious ...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章,评审
doi：10.1016/j.janxdis.2013.03.004
更新日期：2013-12-01 00:00:00
abstract：:The aim of this paper is to report findings on the epidemiology of generalized anxiety disorder (GAD) using data from the Singapore Mental Health Study (SMHS) 2016, and draw comparisons with results from the first SMHS in 2010. Singapore residents aged 18 years and above participated in the household survey where the ...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2019.102106
更新日期：2019-08-01 00:00:00
abstract：:The purpose of this study was to determine the validity of the State-Trait Anxiety Inventory (STAI) in predicting DSM-III-R anxiety disorders based on the Diagnostic Interview Schedule for Children (DISC, Version 2.3) and using Asian/Pacific Islander adolescents. An overall prevalence rate of 9.19% for generalized anx...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/s0887-6185(01)00079-2
更新日期：2001-11-01 00:00:00
abstract：:In this study, the cost-effectiveness of three indicated anxiety prevention strategies was examined from a societal perspective. Children (aged 8-12) were recruited via primary schools, selecting children scoring as high-anxious on an anxiety screening questionnaire. Participating children and their parents were rando...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.janxdis.2011.12.008
更新日期：2012-03-01 00:00:00
abstract：:A considerable body of research has identified various child and parent factors that contribute to and maintain anxiety symptoms in children. Yet relatively few studies have examined child factors (including threat-based cognitive bias, neuroticism, gender, puberty and age) as well as parent factors (including materna...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2012.06.002
更新日期：2012-10-01 00:00:00
abstract：:Inhibitory control over thoughts, emotions, and actions is challenging for people with Post-Traumatic Stress Disorder (PTSD). Whether specific aspects of inhibitory control are differentially affected in PTSD remains an open question. Here we examined performance on two popular response inhibition tasks in 28 combat V...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2020.102278
更新日期：2020-10-01 00:00:00
abstract：:This comparative, cross-sectional community-based study examines sex differences in associations between various types of impairment and high level of social phobia/anxiety symptoms (SPAS) in adults aged 30, 40, and 45 years and their controls. Men with high SPAS had higher rates of non-paired relationships, alcohol p...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2010.03.005
更新日期：2010-06-01 00:00:00
abstract：:Tonic immobility (TI) is an involuntary component of the fear response that is characterized by freezing or immobility in situations involving extreme fear coupled with physical restraint. The present investigation evaluated the factor structure of the Tonic Immobility Scale (TIS; Forsyth, J. P., Marx, B., Fusé, T. M....
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2006.05.004
更新日期：2007-01-01 00:00:00
abstract：:Research demonstrates substantial comorbidity between PTSD and alcohol use disorders. Evidence for functional relationships between PTSD and problematic alcohol use has not always been consistent, and there have been few investigations with adolescent samples. Further, research has not consistently controlled for cumu...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2011.06.006
更新日期：2011-10-01 00:00:00
abstract：:Climate change will affect psychological wellbeing. Substantial research has documented harmful impacts on physical health, mental health, and social relations from exposure to extreme weather events that are associated with climate change. Recently, attention has turned to the possible effects of climate change on me...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2020.102263
更新日期：2020-08-01 00:00:00
abstract：:Worry, the anticipation of future threat, is a common feature of anxiety and mood psychopathology. Considerable research has examined the latent structure of worry to determine whether this construct reflects a dimensional or taxonic structure. Recent taxometric investigations have provided support for a unidimensiona...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2015.11.001
更新日期：2016-01-01 00:00:00
abstract：:Evidence suggests that anxiety sensitivity (AS) contributes to individual differences in fearfulness and to the risk of developing anxiety disorders. To investigate the origins of AS we administered the Anxiety Sensitivity Index to 245 monozygotic and 193 dizygotic twin pairs, comprising 658 women and 218 men. Scores ...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/j.janxdis.2007.09.005
更新日期：2008-06-01 00:00:00
abstract：:Benzodiazepines (BZs) are commonly used in conjunction with cognitive behavioral therapy (CBT) in the treatment of panic disorder with agoraphobia (PDA). However, empirical evidence provides little support for the utility of this combined treatment approach over CBT alone. Westra and Stewart [Clin. Psychol. Rev. 18 (1...
journal_title：Journal of anxiety disorders
pub_type： 杂志文章
doi：10.1016/s0887-6185(02)00091-9
更新日期：2002-01-01 00:00:00
