No association between the -399 C > T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population.

Abstract:

OBJECTIVE:A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population. METHOD:We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716). RESULTS:We detected the polymorphism -399 C > T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups. CONCLUSION:The lack of association between the -399 C > T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.

journal_name

Acta Psychiatr Scand

authors

Lindberg C,Koefoed P,Hansen ES,Bolwig TG,Rehfeld JF,Mellerup E,Jørgensen OS,Kessing LV,Werge T,Haugbøl S,Wang AG,Woldbye DP

doi

10.1111/j.1600-0447.2005.00648.x

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

54-8

issue

1

eissn

0001-690X

issn

1600-0447

pii

ACP648

journal_volume

113

pub_type

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