Involvement of Bcl-X(L) deamidation in E1A-mediated cisplatin sensitization of ovarian cancer cells.

abstract：:Fos-related antigen-1 (Fra-1) is a member of the Activator Protein-1 (AP-1) transcription factor superfamily that is overexpressed in a variety of cancers, including colon, breast, lung, bladder and brain. High Fra-1 levels are associated with enhanced cell proliferation, survival, migration and invasion. Despite its ...

journal_title：Oncogene

authors： Pakay JL,Diesch J,Gilan O,Yip YY,Sayan E,Kolch W,Mariadason JM,Hannan RD,Tulchinsky E,Dhillon AS

更新日期：2012-04-05 00:00:00

abstract：:The hepatitis B virus (HBV) X protein (pX) stimulates transcription regulated by cis-acting elements that control many viral and cellular genes, including the c-myc and the c-fos proto-oncogenes. Using several c-fos promoter deletion mutants, we found the serum-responsive element (SRE) located at -315, the modified TP...

journal_title：Oncogene

authors： Avantaggiati ML,Natoli G,Balsano C,Chirillo P,Artini M,De Marzio E,Collepardo D,Levrero M

更新日期：1993-06-01 00:00:00

abstract：:Ferritin is the major intracellular iron storage protein that sequesters excess free iron to minimize generation of iron-catalysed reactive oxygen species. We previously demonstrated that expression of ferritin heavy chain (ferritin H) was induced by pro-oxidants, which is a part of cellular antioxidant response to pr...

journal_title：Oncogene

authors： Tsuji Y

更新日期：2005-11-17 00:00:00

abstract：:To elucidate the mechanisms behind the high sensitivity of myxoid/round cell liposarcoma (MRCL) to trabectedin and the suggested selectivity for specific subtypes, we have developed and characterized three MRCL xenografts, namely ML017, ML015 and ML004 differing for the break point of the fusion gene FUS-CHOP, respect...

journal_title：Oncogene

authors： Di Giandomenico S,Frapolli R,Bello E,Uboldi S,Licandro SA,Marchini S,Beltrame L,Brich S,Mauro V,Tamborini E,Pilotti S,Casali PG,Grosso F,Sanfilippo R,Gronchi A,Mantovani R,Gatta R,Galmarini CM,Sousa-Faro JM,D'Incalc

更新日期：2014-10-30 00:00:00

abstract：:The precise genetic mechanism of malignant transformation in DNA mismatch repair deficient, microsatellite-unstable colorectal cancer (CRC) has yet to be elucidated. We employed cDNA microarray to identify patterns of gene expression among CRC cell lines and to compare directly lines with and without microsatellite in...

journal_title：Oncogene

authors： Yuan Z,Sotsky Kent T,Weber TK

更新日期：2003-09-18 00:00:00

abstract：:In breast cancer (BC) patients, local recurrences often arise in proximity of the surgical scar, suggesting that response to surgery may have a causative role. Radiotherapy (RT) after lumpectomy significantly reduces the risk of recurrence. We investigated the direct effects of surgery and of RT delivered intraoperati...

journal_title：Oncogene

authors： Fabris L,Berton S,Citron F,D'Andrea S,Segatto I,Nicoloso MS,Massarut S,Armenia J,Zafarana G,Rossi S,Ivan C,Perin T,Vaidya JS,Avanzo M,Roncadin M,Schiappacassi M,Bristow RG,Calin G,Baldassarre G,Belletti B

更新日期：2016-09-15 00:00:00

abstract：:Pdcd4 is a novel transformation suppressor that is highly expressed in promotion-resistant (P-) mouse epidermal JB6 cells but not in susceptible (P+) cells. Overexpression of pdcd4 cDNA in stably transfected P+ cells rendered cells resistant to tumor promoter-induced transformation, indicating that elevated expression...

journal_title：Oncogene

authors： Yang HS,Jansen AP,Nair R,Shibahara K,Verma AK,Cmarik JL,Colburn NH

更新日期：2001-02-08 00:00:00

abstract：:Recent genetic investigations have established that RhoB gain-of-function is sufficient to mediate the antitransforming effects of farnesyltransferase inhibitors (FTIs) in H-Ras-transformed fibroblast systems. In this study, we addressed the breadth and mechanism of RhoB action in epithelial cells transformed by oncop...

journal_title：Oncogene

authors： Zeng PY,Rane N,Du W,Chintapalli J,Prendergast GC

更新日期：2003-02-27 00:00:00

abstract：:Recently Gadd45, a p53-regulated stress protein, has been implicated in the activation of a G2/M checkpoint after damage by UV radiation and alkylating agents. While inhibitory phosphorylation of Cdc2 and suppression of cyclin B1 levels are known to be involved in G2 delays after genotoxic stress, Gadd45 has now been ...

journal_title：Oncogene

authors： Zhan Q,Antinore MJ,Wang XW,Carrier F,Smith ML,Harris CC,Fornace AJ Jr

更新日期：1999-05-06 00:00:00

abstract：:Inactivation of the tumor suppressor NF2/merlin underlies neurofibromatosis type 2 (NF2) and some sporadic tumors. Previous studies have established that merlin mediates contact inhibition of proliferation; however, the exact mechanisms remain obscure and multiple pathways have been implicated. We have previously repo...

journal_title：Oncogene

authors： Cui Y,Groth S,Troutman S,Carlstedt A,Sperka T,Riecken LB,Kissil JL,Jin H,Morrison H

更新日期：2019-09-01 00:00:00

abstract：:The Cbl family proteins Cbl, Cbl-b, and Cbl-c/Cbl-3 are thought to regulate signaling through protein-tyrosine kinases, positively as scaffold proteins and negatively as ubiquitin ligases. However, the precise signaling pathways and target proteins for each Cbl family member are not well understood. Here we show that ...

journal_title：Oncogene

authors： Kim M,Tezuka T,Tanaka K,Yamamoto T

更新日期：2004-03-04 00:00:00

abstract：:Provirus modifications which can occur in tumors may lead to tumor antigenic variants. To investigate this possibility we compared the restriction fragment length patterns of mouse mammary tumor virus (MMTV), murine leukemia virus and xenotropic and mink cell-focus inducing (MCF)-related sequences, using Southern blot...

journal_title：Oncogene

authors： Colombo MP,Ferrari G,Parmiani G,Wettstein PJ

更新日期：1988-04-01 00:00:00

abstract：:We determined whether proteins encoded by the nm23/nucleoside diphosphate (NDP) kinase gene, a potential metastasis-suppressor gene, are expressed on the cell surface. Monoclonal antibodies (mAb) specific for nm23-H1 or H2 proteins were prepared using the corresponding fusion proteins with glutathione S-transferase (G...

journal_title：Oncogene

authors： Urano T,Furukawa K,Shiku H

更新日期：1993-05-01 00:00:00

abstract：:A single heat shock factor (HSF), mediating the heat shock response, exists from yeast to Drosophila, whereas several related HSFs have been found in mammals. This raises the question of the specific or redundant functions of the different members of the HSF family and in particular of HSF1 and HSF2, which are both ub...

journal_title：Oncogene

authors： Lecomte S,Desmots F,Le Masson F,Le Goff P,Michel D,Christians ES,Le Dréan Y

更新日期：2010-07-22 00:00:00

abstract：:The REL gene is amplified in many human B-cell lymphomas and we have previously shown that expression of REL from a retroviral vector can malignantly transform chicken spleen cells in vitro. To identify REL protein functions necessary for malignant transformation, we have performed deletion analysis on REL sequences e...

journal_title：Oncogene

authors： Starczynowski DT,Reynolds JG,Gilmore TD

更新日期：2003-10-09 00:00:00

abstract：:Cellular senescence functions as a tumor suppressor that protects against cancer progression. α-Catulin, an α-catenin-related protein, is reported to have tumorigenic potential because it regulates the nuclear factor-κB (NF-κB) pathway, but little is known about its clinical relevance and the mechanism through which i...

journal_title：Oncogene

authors： Fan LC,Chiang WF,Liang CH,Tsai YT,Wong TY,Chen KC,Hong TM,Chen YL

更新日期：2011-06-09 00:00:00

abstract：:Eukaryotic translation can be initiated either by a cap-dependent mechanism or by internal ribosome entry, a process by which ribosomes are directly recruited to structured regions of mRNA upstream of the initiation codon. Here we report the finding of an internal ribosome entry site (IRES) in the untranslated region ...

journal_title：Oncogene

authors： Isaksson A,Berggren M,Ricksten A

更新日期：2003-01-30 00:00:00

abstract：:G2A is a heptahelical cell surface protein that has recently been described as a potential tumor suppressor, based on its ability to counteract transformation of pre-B cells and fibroblasts by Bcr-Abl, an oncogenic tyrosine kinase. We have isolated cDNAs encoding G2A in the course of screening libraries for clones tha...

journal_title：Oncogene

authors： Zohn IE,Klinger M,Karp X,Kirk H,Symons M,Chrzanowska-Wodnicka M,Der CJ,Kay RJ

更新日期：2000-08-10 00:00:00

abstract：:Proliferating cell nuclear antigen (PCNA) has no intrinsic enzymatic function, but functions as a sliding platform to mediate protein interactions with the DNA strand. Many proteins interact with PCNA through a small conserved motif with consensus QxxLxxFF. This work uses Schizosaccharomyces pombe and human cells to a...

journal_title：Oncogene

authors： Warbrick E

更新日期：2006-05-11 00:00:00

abstract：:The Abelson (Abl) family of non-receptor tyrosine kinases has an important role in cell morphogenesis, motility, and proliferation. Although the function of Abl has been extensively studied in leukemia, its role in epithelial cell invasion remains obscure. Using the Drosophila wing epithelium as an in vivo model syste...

journal_title：Oncogene

authors： Singh J,Aaronson SA,Mlodzik M

更新日期：2010-07-15 00:00:00

abstract：:Upstream stimulating factor (USF2) is a basic helix-loop-helix leucine zipper transcription factor, which is found in most tissues. A critical role for USF2 in cellular proliferation has been proposed based on its importance in the regulation of various cyclins and P53 and its capability to antagonize c-myc. In this p...

journal_title：Oncogene

authors： Zhang ZC,Nechushtan H,Jacob-Hirsch J,Avni D,Meyuhas O,Razin E

更新日期：1998-02-12 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD) is a nuclear encoded and mitochondrial matrix-localized redox enzyme that is known to regulate the cellular redox environment. Cellular redox environment changes during transitions between quiescent and proliferative cycles. Human MnSOD has two poly(A) sites resulting in two tran...

journal_title：Oncogene

authors： Chaudhuri L,Nicholson AM,Kalen AL,Goswami PC

更新日期：2012-03-08 00:00:00

abstract：:Low dose treatment with the DNA methylation inhibitor decitabine has been shown to be applicable for the management of certain types of cancer. However, its antitumor effect and mechanisms are context dependent and its activity has never been systematically studied in bladder cancer treatment. We used mouse models, cu...

journal_title：Oncogene

authors： Wu M,Sheng L,Cheng M,Zhang H,Jiang Y,Lin S,Liang Y,Zhu F,Liu Z,Zhang Y,Zhang X,Gao Q,Chen D,Li J,Li Y

更新日期：2019-07-01 00:00:00

abstract：:Apoptotic cell death is an active process which regulates the maintenance of the hematopoietic homeostasis. It has been reported that wild-type p53 (wt-p53) protein induces apoptosis in leukemia cells. To assess whether p53 is involved in the apoptotic process of normal hematopoietic cells, we introduced the temperatu...

journal_title：Oncogene

authors： Blandino G,Scardigli R,Rizzo MG,Crescenzi M,Soddu S,Sacchi A

更新日期：1995-02-16 00:00:00

abstract：:Loss of p53 function is associated with the acquisition of cisplatin resistance in the human ovarian adenocarcinoma A2780 cell line. Selection for cisplatin resistance of A2780 cells was used to isolate genetic suppressor elements (GSEs) from a retroviral library expressing random fragments of human or murine TP53 cDN...

journal_title：Oncogene

authors： Gallagher WM,Cairney M,Schott B,Roninson IB,Brown R

更新日期：1997-01-16 00:00:00

abstract：:As tumors grow and invade beyond their homeostatic limits, the tumor cells are subjected to insufficient nutrient and oxygen supplies because of excessive demand for nutrition and oxygen, and insufficient vascularization. We therefore hypothesized that tolerance to nutrient deprivation as well as angiogenesis may be c...

journal_title：Oncogene

authors： Kato K,Ogura T,Kishimoto A,Minegishi Y,Nakajima N,Miyazaki M,Esumi H

更新日期：2002-09-05 00:00:00

abstract：:The crizotinib-resistant ALK(F1174L) mutation arises de novo in neuroblastoma (NB) and is acquired in ALK translocation-driven cancers, lending impetus to the development of novel anaplastic lymphoma kinase (ALK) inhibitors with different modes of action. The diaminopyrimidine TAE684 and its derivative ceritinib (LDK3...

journal_title：Oncogene

authors： Debruyne DN,Bhatnagar N,Sharma B,Luther W,Moore NF,Cheung NK,Gray NS,George RE

更新日期：2016-07-14 00:00:00

abstract：:Growth arrest after u.v. damage was investigated in C3H mouse primary cultured hepatocytes, spontaneously immortalized liver epithelial cells and their H-ras-transformed derivatives. All cells except for one of the transformed lines had the wild type p53 gene considered necessary for the G1-S checkpoint. Growth arrest...

journal_title：Oncogene

authors： Kadohama T,Tsuji K,Ogawa K

更新日期：1994-10-01 00:00:00

abstract：:In order to obtain insight into the parameters determining the subcellular localization of mutant and wild-type forms of p53, we analysed the subcellular distribution of p53 in four Balb/c mouse-derived cell lines ranging in their cellular phenotypes from normal (3T3), via minimal transformant (T3T3), to maximally tra...

journal_title：Oncogene

authors： Zerrahn J,Deppert W,Weidemann D,Patschinsky T,Richards F,Milner J

更新日期：1992-07-01 00:00:00

abstract：:Transcription factors of the Maf proto-oncogene family have been shown to participate in the regulation of several differentiation specific genes. We previously reported that a member(s) of this family is involved in the regulation of the neuroretina specific gene, QR1, through a promoter region, designated the A box,...

journal_title：Oncogene

authors： Benkhelifa S,Provot S,Lecoq O,Pouponnot C,Calothy G,Felder-Schmittbuhl MP

更新日期：1998-07-16 00:00:00