Abstract：
BACKGROUND AND OBJECTIVES:Prolongation of the QT interval may result in grave cardiac arrhythmias, polymorphic ventricular tachycardia ("torsades de pointes"), and ventricular fibrillation. We assessed the influence of spinal anesthesia on the QTc interval and the potential arrhythmogenicity of this method of anesthesia. METHODS:Assessment was performed in 20 male unpremedicated patients, I or II American Society of Anesthesiologists physical status, who underwent spinal anesthesia for elective surgical procedures. Values of the QTc interval, heart rate, and arterial pressure were measured before spinal anesthesia as well as after 1, 3, 5, and 15 minutes of adequate blockade. RESULTS:Statistically significant lengthening of the QTc interval (compared with initial values) was observed in the first minute after blockade and in subsequent measurements. No differences were observed between mean values of the QTc interval after the onset of blockade. No significant changes in heart rate were noted. From the third minute on, significant decreases of the systolic, diastolic, and mean arterial blood pressure were observed as compared with baseline. These decreases in systolic, diastolic, and mean arterial blood pressure persisted for the entire study duration. No one patient developed clinically important cardiac arrhythmias. CONCLUSIONS:Spinal anesthesia provokes significant QTc interval prolongation in patients without cardiovascular disorders.
journal_name
Reg Anesth Pain Medjournal_title
Regional anesthesia and pain medicineauthors
Owczuk R,Sawicka W,Wujtewicz MA,Kawecka A,Lasek J,Wujtewicz Mdoi
10.1016/j.rapm.2005.06.005subject
Has Abstractpub_date
2005-11-01 00:00:00pages
548-52issue
6eissn
1098-7339issn
1532-8651pii
S1098-7339(05)00232-4journal_volume
30pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVES:Certain factors, such as intervertebral disc herniation, previous spinal surgery, and osteoarthritis may cause problems during the midline epidural procedure. The purpose of this study was to investigate the placement of the needle tip in an alternative paramedian approach in a cadaver, and ra...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1053/rapm.2003.50129
更新日期：2003-05-01 00:00:00
abstract：:Continuous peripheral nerve blockade has become a popular method of achieving postoperative analgesia for many surgical procedures. The safety and reliability of infusion pumps are dependent on their flow rate accuracy and consistency. Knowledge of pump rate profiles can help physicians determine which infusion pump i...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1097/AAP.0000000000000130
更新日期：2014-09-01 00:00:00
abstract：:β-Adrenergic blockade is an important mechanism for reducing morbidity and mortality in patients with hypertension and heart failure. Esmolol has been used widely for its chronotropic and antihypertensive effects. However, there has been recent inquiry regarding perioperative esmolol use and nociceptive modulation. Co...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章,评审
doi：10.1097/AAP.0000000000000873
更新日期：2018-11-01 00:00:00
abstract：:Despite a growing awareness about the importance of gender equity and the rising number of women in medicine, women remain persistently underrepresented in pain medicine and anesthesiology. Pain medicine ranks among the bottom quartile of medical specialties in terms of female applicants, female trainees, and proporti...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章,评审
doi：10.1097/AAP.0000000000000774
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The American College of Obstetricians & Gynecologists has opposed postpartum tubal ligation (PPTL) in patients whose pregnancies have been complicated by a medical condition, including hypertension. A prospective study was conducted to assess the appropriateness of spinal anesthesia for PPTL i...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1053/rapm.2000.0250170
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Epidural anesthesia (EA) is known to reduce postoperative thromboembolic complications, but mechanisms are incompletely understood. In this study, we tested the hypothesis that local anesthetics (LA) prevent postoperative hypercoagulability without affecting physiologic aggregation and coagula...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1053/rapm.2001.23209
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND/IMPORTANCE:Ultrasound (US)-guided cervical selective nerve root injections (CSNRI) have been proposed as an alternative to fluoroscopic (FL) -guided injections. When choosing US guidance, the proceduralist should be aware of potential issues confirming vertebral level, be clear regarding terminology, and up ...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章,评审
doi：10.1136/rapm-2020-102325
更新日期：2021-01-13 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The aim of this study was to investigate the possible local neurotoxicity of a number of lipid-depot formulations of local anesthetics in relation to their duration of action in sciatic-nerve block. METHODS:Formulations that contain 2%, 4%, 8%, 16%, 32%, or 64% of a mixture of bupivacaine and...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1016/j.rapm.2006.05.008
更新日期：2006-09-01 00:00:00
abstract：:The past century has seen immense progress in the advancement of methodology to evaluate efficacy of treatment interventions for acute and chronic pain. Continuing challenges revolve around how to best select and measure primary efficacy outcomes for a given analgesic trial. Recognizing the complex, multidimensional, ...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章,评审
doi：10.1097/AAP.0b013e318217a635
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:In addition to their blockade of voltage-dependent sodium channels, the action of local anesthetics at 5-hydroxytryptamine-3 (5-HT3) receptors may be clinically relevant. Because local anesthetics have different clinical properties, we have tested the hypothesis that differences in interaction...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1016/j.rapm.2007.06.391
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:Lipid infusion reverses systemic local anesthetic toxicity. The acceptable upper limit for lipid administration is unknown and has direct bearing on clinical management. We hypothesize that high volumes of lipid could have undesirable effects and sought to identify the dose required to kill 50% of the animal...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1097/aap.0b013e3181c6f5aa
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Dorsal root ganglion stimulation is an emerging therapy in the treatment of chronic pain. Compared with traditional spinal cord stimulation, it allows a discretely targeted stimulation profile and may act via differing mechanisms of action. Despite these advantages, little is known about the c...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1136/rapm-2018-000007
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:This study reports our early experience with continuous cervical paravertebral block (CCPVB) using a stimulating catheter for the management of acute pain after shoulder surgery. METHODS:This prospective observational study presents 256 CCPVB for pain relief after 14 different shoulder operat...
journal_title：Regional anesthesia and pain medicine
pub_type： 临床试验,杂志文章
doi：10.1016/s1098-7339(03)00221-9
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:This prospective, randomized, double-blind study compared the effects of the ultrasound-guided popliteal sciatic nerve block performed by either intraneural or subparaneural approach followed by an electrophysiological evaluation. We hypothesized that intraneural injection provides a faster on...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章,随机对照试验
doi：10.1097/AAP.0000000000000413
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Despite ultrasound (US) guidance, sciatic nerve block (SNB) remains among the least performed peripheral blocks. By targeting the tissue plane between the gluteus maximus and quadratus femoris muscles, the US-guided subgluteal space technique may facilitate the performance of US-guided SNB. We...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章,随机对照试验
doi：10.1097/AAP.0000000000000016
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:In order to prolong labor analgesia, one may add intrathecal epinephrine to the combination of bupivacaine and fentanyl. In this study, we tested the hypothesis that the addition of intrathecal epinephrine would lessen the requirement for a rescue dose of epidural analgesia during labor. METH...
journal_title：Regional anesthesia and pain medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1053/rapm.2003.50026
更新日期：2003-03-01 00:00:00
abstract：OBJECTIVE:Local anesthetic-induced cardiotoxicity remains a complication of regional anesthesia, with the potential to result in cardiac arrest refractory to resuscitation. Successful resuscitation using Intralipid (Baxter Pharmaceuticals by Fresenius Kabi, Uppsala, Sweden), has been reported in 2 patients with bupivac...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1016/j.rapm.2007.09.006
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:We have investigated how the vascular components of the spine determine the resistance and capacitance of the spinal epidural space and determined the magnitude of the longitudinal pressure gradient in the space during fluid infusion. METHODS:Pigs were studied during isoflurane anesthesia. Tu...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1097/AAP.0b013e3181958fad
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Ivor-Lewis esophagectomy is associated with significant postoperative analgesic requirements and perioperative complications. A dual-epidural technique may improve perioperative outcomes compared with single thoracic epidural analgesia. METHODS:This study identified all cases of Ivor-Lewis esophagectomy ove...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1097/AAP.0b013e318276a714
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:Our objective was to describe the first reported use of an axillary brachial plexus block to treat the entrapment of a transradial artery catheter due to vasospasm. CASE REPORT:A 42-year-old man undergoing transradial arterial cardiac catheterization suffered arterial vasospasm causing the catheter to become...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1097/AAP.0000000000000595
更新日期：2017-07-01 00:00:00
abstract：:Directors for Regional Anesthesiology and Acute Pain Medicine fellowships develop and maintain guidelines for fellowship training in the subspecialty. The first edition of the guidelines was published in 2005 with a revision published in 2010. This set of guidelines updates the 2010 revision. The guidelines address 3 ...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章,实务指引
doi：10.1097/AAP.0000000000000233
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:Femoral nerve block (FNB) is increasingly used as an analgesic modality in patients with femoral fracture both in the emergency department and preoperatively. We describe an occurrence of unexpected dislocation of the fracture after FNB. CASE REPORT:An FNB was administered to treat pain in a 48-year-old pati...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1097/AAP.0000000000000049
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Use of nonsteroidal anti-inflammatory drug (NSAIDs) analgesics is controversial because of cardiovascular risk, but perioperative use may be advantageous for total joint replacement. Thus, we performed this single-center observational cohort study to determine any association between NSAID use...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1097/AAP.0b013e31823354f5
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:This study examined whether perioperative multimodal analgesia (MMA) improves the effectiveness of intravenous nutrition (IVN) as a means of preventing protein wasting following major upper abdominal surgery (UAS). The MMA regimen utilized combined epidural opioid/local anesthetic and the syst...
journal_title：Regional anesthesia and pain medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1053/rapm.2002.27850
更新日期：2002-01-01 00:00:00
abstract：:This article provides a brief overview of earlier work of our group on the peripheral signaling of pain, summarizes more recent studies on the role of opioids in chronic neuropathic pain, and speculates on the future of gene-based therapies as novel strategies to enhance the peripheral modulation of pain. Neurophysiol...
journal_title：Regional anesthesia and pain medicine
pub_type：
doi：10.1097/AAP.0b013e31823b145f
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:Postdural puncture headache (PDPH) is an uncommon sequel of lumbar puncture in children. When conservative treatment with bed rest, hydration, and caffeine are ineffective, epidural blood patches are recommended and are generally effective. The purpose of this report was to highlight that when lumbar epidural...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1097/AAP.0000000000000562
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:This report describes the effects of ganglionic local opioid application (GLOA) in patients with chronic headache and persistent idiopathic facial pain. CASE REPORT:We present 2 patients with chronic headaches and 1 patient with persistent idiopathic facial pain who were refractory to medical treatment. Thes...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1016/j.rapm.2006.03.011
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Peripheral nerve and spinal cord stimulation techniques have been used for many years. However, electrical stimulation methods rarely have been used to confirm epidural catheter placement. This study examines the practicality of this technique to confirm epidural catheter placement in obstetri...
journal_title：Regional anesthesia and pain medicine
pub_type： 临床试验,杂志文章
doi：10.1016/s1098-7339(99)90160-8
更新日期：1999-01-01 00:00:00
abstract：:The American Society of Regional Anesthesia and Pain Medicine (ASRA) periodically updates its practice advisories and associated cognitive aids. The 2020 version of the ASRA Local Anesthetic Systemic Toxicity checklist was created in response to user feedback, simulation studies and advances in medical knowledge. This...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1136/rapm-2020-101986
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Peripheral nerve stimulation (PNS) is analgesic for some lower extremity neuropathic pain syndromes. PNS currently involves open surgical placement of electrode(s). Increasingly, ultrasound guidance is used for perioperative neural block. Minimally invasive placement of PNS electrodes for lowe...
journal_title：Regional anesthesia and pain medicine
pub_type： 杂志文章
doi：10.1016/j.rapm.2008.04.007
更新日期：2008-11-01 00:00:00
