Diameter of non-small cell lung cancer correlates with long-term survival: implications for T stage.

Abstract:

STUDY OBJECTIVES:To determine the effect of tumor diameter on the long-term survival of patients with stage I non-small cell lung cancer (NSCLC) within a large multi-institutional database, and to assess the accuracy of the T-descriptor threshold of 3 cm. DESIGN AND PATIENTS:A total of 9,191 patients > or = 20 years old with surgically treated stage I NSCLC < or = 6 cm registered in the Surveillance, Epidemiology, and End Results database from 1992 to 1997 were included. The size of the nodule was grouped into six categories: < 1 cm (n = 191, 2%), 1 to 1.9 cm (n = 2,130, 23%), 2 to 2.9 cm (n = 2,851, 31%), 3 to 3.9 cm (n = 1,984, 22%), 4 to 4.9 cm (n = 1,161, 13%), and 5 to 6 cm (n = 874, 9%). Due to its limited sample size, subcentimeter nodules were not included in the survival analysis. Survival analyses were performed with Kaplan-Meier estimates, log-rank tests, and Cox proportional hazards models. MEASUREMENTS AND RESULTS:A total of 4,904 (53%) men and 4,287 women (mean +/- SD age, 66.6 +/- 9.4 years) with stage I NSCLC were analyzed. The use of lobectomies and pneumonectomies as surgical treatment instead of limited resections increased with the size of the tumor, from 62% in subcentimeter nodules to 96% in 5- to 6-cm tumors (p < 0.0001). Survival decreased with increasing size of the tumor (p < 0.0001). There was a significant survival difference when size groups were compared to tumors 1.0 to 1.9 cm: 2.0 to 2.9 cm (hazard ratio [HR], 1.3; 95% confidence interval [CI], 1.16 to 1.47), 3.0 to 3.9 cm (HR, 1.49; 95% CI, 1.32 to 1.69), 4.0 to 4.9 cm (HR, 1.82; 95% CI, 1.59 to 2.08), and 5.0 to 6.0 cm (HR, 2.04; 95% CI, 1.77 to 2.36). Survival was similar in tumors between 2.0 to 2.9 cm and 3.0 to 3.9 cm, and in tumors between 4.0 to 4.9 cm and 5.0 to 6.0 cm. CONCLUSIONS:The T descriptor should be changed so that T1 is reserved for tumors < 2 cm. Further refinement of larger tumors into T2a (2 to 3.9 cm) and T2b (> or = 4 cm) should be considered.

journal_name

Chest

journal_title

Chest

authors

Mery CM,Pappas AN,Burt BM,Bueno R,Linden PA,Sugarbaker DJ,Jaklitsch MT

doi

10.1378/chest.128.5.3255

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

3255-60

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)52886-9

journal_volume

128

pub_type

杂志文章

相关文献

CHEST文献大全
  • Contribution of the Mitochondria to Locomotor Muscle Dysfunction in Patients With COPD.

    abstract::COPD is a significant public health challenge, notably set to become the third leading cause of death and fifth leading cause of chronic disability worldwide by the next decade. Skeletal muscle impairment is now recognized as a disabling, extrapulmonary consequence of COPD that is associated with reduced quality of li...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2015.11.021

    authors: Taivassalo T,Hussain SN

    更新日期:2016-05-01 00:00:00

  • Physiologic evaluation of pressure support ventilation by nasal mask in patients with stable COPD.

    abstract::We evaluated the physiologic effects of pressure support ventilation by nasal route (NPSV) in eight patients with severe stable COPD and chronic hypercapnia who were randomly submitted to 2-h sessions of NPSV both with a portable ventilator (Respironics BIPAP device) and with a standard ventilator (Bird 6400ST device)...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.101.2.385

    authors: Ambrosino N,Nava S,Bertone P,Fracchia C,Rampulla C

    更新日期:1992-02-01 00:00:00

  • Thrombocytopenia in cardiovascular patients: diagnosis and management.

    abstract::Thrombocytopenia is a common problem in cardiovascular patients, but the etiology and management of this condition may be different than those in other populations. Around the time that percutaneous coronary interventions are performed, the drugs most commonly associated with thrombocytopenia are the glycoprotein (GP)...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.127.2_suppl.46S

    authors: Matthai WH Jr

    更新日期:2005-02-01 00:00:00

  • Decision-Making on Withholding or Withdrawing Life Support in the ICU: A Worldwide Perspective.

    abstract:BACKGROUND:Many critically ill patients who die will do so after a decision has been made to withhold/withdraw life-sustaining therapy. The objective of this study was to document the characteristics of ICU patients with a decision to withhold/withdraw life-sustaining treatment, including the types of supportive treatm...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.chest.2017.04.176

    authors: Lobo SM,De Simoni FHB,Jakob SM,Estella A,Vadi S,Bluethgen A,Martin-Loeches I,Sakr Y,Vincent JL,ICON investigators.

    更新日期:2017-08-01 00:00:00

  • A comparison of the standard 12-lead electrocardiogram to exercise electrode placements.

    abstract::In order to determine the effect of electrode placement and standing on the 12-lead electrocardiogram required prior to exercise testing, 104 male patients with stable coronary heart disease were studied. Electrocardiograms were recorded with two different placements of the arm electrodes commonly used for exercise te...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.85.5.616

    authors: Gamble P,McManus H,Jensen D,Froelicher V

    更新日期:1984-05-01 00:00:00

  • Extracorporeal life support for status asthmaticus.

    abstract::Status asthmaticus is a life-threatening form of reactive airway disease, refractory to initial control with ordinary medical measures, sometimes requiring mechanical ventilatory assistance. In this report, we describe a patient whose bronchospasm could not be controlled with conventional measures, with severe respira...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.6.1651

    authors: Shapiro MB,Kleaveland AC,Bartlett RH

    更新日期:1993-06-01 00:00:00

  • Recent Dieulafoy's lesion bleeding and massive pulmonary emboli. Successful use of thrombolytic therapy.

    abstract::A massive GI bleed secondary to a Dieulafoy's lesion developed in a 77-year-old woman. Fifteen days later, massive pulmonary emboli developed. We describe successful thrombolytic treatment of her pulmonary emboli without complicating GI hemorrhage. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.110.2.567

    authors: Levin MS,Vernovsky I,Beer DJ

    更新日期:1996-08-01 00:00:00

  • Pulmonary complications of hormone treatment in prostate carcinoma.

    abstract::Fever, dyspnea, dry cough and interstitial fibrosis occurred in a man with prostate carcinoma treated with nilutamide and buserelin for two and one-half months. The diagnosis of drug-induced fibrosis was established on the basis of chronologic and semiologic events. This is the first such case reported. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.5.1106

    authors: Seigneur J,Trechot PF,Hubert J,Lamy P

    更新日期:1988-05-01 00:00:00

  • Low and High Blood Eosinophil Counts as Biomarkers in Hospitalized Acute Exacerbations of COPD.

    abstract:BACKGROUND:Characterizing acute exacerbations of COPD (AECOPD) and individualizing therapy is challenging. Key exacerbation therapies include antibiotics and systemic corticosteroids. Blood eosinophils, when either low or high, may offer a simple, inexpensive distinction to predict beneficial responses to these therapi...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.chest.2019.02.406

    authors: MacDonald MI,Osadnik CR,Bulfin L,Hamza K,Leong P,Wong A,King PT,Bardin PG

    更新日期:2019-07-01 00:00:00

  • Sex differences in awake ventilatory drive and abnormal breathing during sleep in eucapnic obesity.

    abstract::We studied hypoxic and hypercapnic ventilatory drives in 22 eucapnic obese subjects (14 female and eight male subjects) referred for weight reduction therapy and 23 normal subjects (eight female and 15 male subjects). In the female subjects, both occlusion pressure, currently used as an indicator of ventilatory drive,...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.5.968

    authors: Kunitomo F,Kimura H,Tatsumi K,Kuriyama T,Watanabe S,Honda Y

    更新日期:1988-05-01 00:00:00

  • The "lung shift" in treated schistosomiasis. Bronchoalveolar lavage evidence of eosinophilic pneumonia.

    abstract::There is conflicting and incomplete information in the literature on the pulmonary reaction which can occur following treatment of schistosomiasis. We examined the pulmonary function, bronchoalveolar lavage profile, and lung histopathology of a patient with pneumonia and peripheral eosinophilia following oxaminquine c...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.89.3.455

    authors: Davidson BL,el-Kassimi F,Uz-Zaman A,Pillai DK

    更新日期:1986-03-01 00:00:00

  • Elevated levels of soluble interleukin-2 receptors in tuberculous pleural effusions.

    abstract::The levels of soluble IL-2R were measured in pleural fluid from patients with tuberculosis pleurisy. There were significantly elevated soluble IL-2R values in tuberculous pleural fluid as compared with pleural fluid of nontuberculous etiology including malignant, bacterial and transudative pleural effusions. In patien...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.5.1141

    authors: Ito M,Kojiro N,Shirasaka T,Moriwaki Y,Tachibana I,Kokubu T

    更新日期:1990-05-01 00:00:00

  • Decrease in mortality in severe community-acquired pneumococcal pneumonia: impact of improving antibiotic strategies (2000-2013).

    abstract:OBJECTIVE:The objective of the present study was to compare antibiotic prescribing practices and survival in the ICU for patients with pneumococcal severe community-acquired pneumonia (SCAP) between 2000 and 2013. METHODS:This was a matched case-control study of two prospectively recorded cohorts in Europe. Eighty pat...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.13-1531

    authors: Gattarello S,Borgatta B,Solé-Violán J,Vallés J,Vidaur L,Zaragoza R,Torres A,Rello J,Community-Acquired Pneumonia en la Unidad de Cuidados Intensivos II Study Investigators*.

    更新日期:2014-07-01 00:00:00

  • Seeking a home for a PET, part 3: Emerging applications of positron emission tomography imaging in the management of patients with lung cancer.

    abstract::Positron emission tomography (PET) imaging is an important tool to refine the diagnosis and staging approach in patients with a possible lung cancer. In addition, other applications of PET imaging are being explored. Data consistently show that the intensity of uptake on a PET scan correlates with the biological aggre...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.126.5.1656

    authors: Detterbeck FC,Vansteenkiste JF,Morris DE,Dooms CA,Khandani AH,Socinski MA

    更新日期:2004-11-01 00:00:00

  • Detection of unstable angina by 99m technetium pyrophosphate myocardial scintigraphy.

    abstract::99mTechnetium stannous pyrophosphate has been shown to accumulate in acutely infarcted myocardium. To determine if the isotope is also taken up by severely ischemic, but not necrotic myocardium, we performed myocardial scintigraphic studies in 17 patients with chest pains. Seven of the patients satisfied conventional ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.69.2.168

    authors: Abdulla AM,Canedo MI,Cortez BC,McGinnis KD,Wilhelm SK

    更新日期:1976-02-01 00:00:00

  • Diagnosis of superior vena caval obstruction by transesophageal echocardiography.

    abstract::Superior vena caval (SVC) syndrome may be caused by extravascular compression or intravascular obstruction. Knowing the mechanism of SVC syndrome enables the physician to choose appropriate treatment. Transesophageal echocardiography (TEE) is a safe bedside procedure that is excellent for evaluating the SVC and its su...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.3.874

    authors: Ayala K,Chandrasekaran K,Karalis DG,Parris TM,Ross JJ Jr

    更新日期:1992-03-01 00:00:00

  • Graphs.

    abstract::Two rules of good graphs are presented and explicated. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.130.2.620

    authors: Green J

    更新日期:2006-08-01 00:00:00

  • Effect of inhaled corticosteroid therapy on CT scan-estimated airway dimensions in a patient with chronic bronchitis related to ulcerative colitis.

    abstract::CT scanning allows assessment of airway-wall thickness and is useful for diagnosing and assessing various lung diseases, including asthma and COPD. Several studies have reported that CT scan-estimated dimensions are positively correlated with pulmonary function test results and a positive response to treatment. Howeve...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-1105

    authors: Hamada S,Ito Y,Imai S,Oguma T,Niimi A,Mishima M

    更新日期:2011-04-01 00:00:00

  • Pulmonary embolism among patients with a nearly normal ventilation/perfusion lung scan.

    abstract:BACKGROUND:Among patients with nearly normal ventilation/perfusion (V/Q) lung scans in the Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED), pulmonary embolism (PE) was diagnosed more frequently in those who underwent pulmonary angiography than in those in whom PE was diagnosed on the basis of an adve...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.110.2.395

    authors: Henry JW,Stein PD,Gottschalk A,Raskob GE

    更新日期:1996-08-01 00:00:00

  • Mine is bigger than yours: measures of effect size in research.

    abstract::Results of studies that use laboratory tests are often easy to interpret, because we are familiar with the units and how to interpret them. However, this is not the case when the results are presented as ORs, relative risks, correlation, or scores on an unfamiliar scale. This article explains these various indices of ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.11-2473

    authors: Streiner DL,Norman GR

    更新日期:2012-03-01 00:00:00

  • Sleep medicine practices, training, and attitudes: a wake-up call for pulmonologists.

    abstract:STUDY OBJECTIVES:To determine attitudes and knowledge about sleep medicine among chest physicians. DESIGN:: Interactive survey of self-selected respondents. SETTING:Interactive session at the 1998 American College of Chest Physicians (ACCP) annual meeting. PARTICIPANTS:Approximately 60 chest physicians. INTERVENTIO...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.117.6.1603

    authors: Phillips B,Collop N,Goldberg R

    更新日期:2000-06-01 00:00:00

  • Pocket hematoma after pacemaker or implantable cardioverter defibrillator surgery: influence of patient morbidity, operation strategy, and perioperative antiplatelet/anticoagulation therapy.

    abstract:STUDY OBJECTIVES:Pocket hematoma is a common complication after pacemaker or implantable cardioverter defibrillator (ICD) implantation. Thus, we investigated the influence of patient comorbidity, implantation strategy, operator experience, antiplatelet therapy, and anticoagulation therapy on hematoma rate. DESIGN:Betw...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.126.4.1177

    authors: Wiegand UK,LeJeune D,Boguschewski F,Bonnemeier H,Eberhardt F,Schunkert H,Bode F

    更新日期:2004-10-01 00:00:00

  • Incidence and natural history of phrenic neuropathy occurring during open heart surgery.

    abstract:OBJECTIVE:To study the incidence of phrenic neuropathy following coronary artery bypass grafting and determine long-term outcome. DESIGN:Prospective observational. SETTING:Surgical ICU in a university hospital, out-patient follow-up. PATIENTS:Ninety-two consecutive patients undergoing open heart surgery. INTERVENTI...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.3.850

    authors: DeVita MA,Robinson LR,Rehder J,Hattler B,Cohen C

    更新日期:1993-03-01 00:00:00

  • Diastolic rumbles in normally functioning porcine mitral valves.

    abstract::Fourteen of 22 patients (64%) with normally functioning porcine prosthetic valves in the mitral position had apical diastolic rumbles on phonocardiogram and by auscultation. Six (27%) had opening snaps. Factors necessary for the production of a diastolic rumble appear to include central flow, a flexible stent, and the...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.73.2.189

    authors: Mirro MJ,Phyhel HJ,Wann LS,Weyman AE,Tavel ME,Stewart J

    更新日期:1978-02-01 00:00:00

  • Peripheral arterial embolism due to a left ventricular diverticulum in a young adult.

    abstract::A 32-year-old man was admitted to the emergency department of our hospital after experiencing a peripheral arterial embolism. Investigation of the possible embolic sources in an otherwise asymptomatic patient revealed the existence of a left ventricular diverticulum. The left ventricular diverticulum is a rare congeni...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.127.4.1452

    authors: Parthenakis FI,Kochiadakis GE,Patrianakos AP,Hamilos MI,Mitrouska I,Katsamouris AN,Vardas PE

    更新日期:2005-04-01 00:00:00

  • Comparison of lung expansion techniques on thoracoabdominal mechanics and incidence of pulmonary complications after upper abdominal surgery: a randomized and controlled trial.

    abstract:OBJECTIVE:Lung expansion techniques (LETs) are widely used to prevent postoperative pulmonary complications (PPCs). However, the effects of each of these techniques on thoracoabdominal mechanics and PPC incidence after abdominal surgery remain unclear. The objective of this study was to compare the effects of LET on pu...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1378/chest.14-2696

    authors: Lunardi AC,Paisani DM,Silva CCBMD,Cano DP,Tanaka C,Carvalho CRF

    更新日期:2015-10-01 00:00:00

  • Bosentan decreases pulmonary vascular resistance and improves exercise capacity in acute hypoxia.

    abstract:BACKGROUND:Altitude exposure is associated with mild pulmonary hypertension and decreased exercise capacity. We tested the hypothesis that pulmonary vascular resistance (PVR) contributes to decreased exercise capacity in hypoxic healthy subjects. METHODS:An incremental cycle ergometer cardiopulmonary exercise test and...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1378/chest.08-2222

    authors: Faoro V,Boldingh S,Moreels M,Martinez S,Lamotte M,Unger P,Brimioulle S,Huez S,Naeije R

    更新日期:2009-05-01 00:00:00

  • Variable severity of pulmonary disease in adults with identical cystic fibrosis mutations.

    abstract::Adults with CF followed in a university center were assessed for the presence of the most common CF gene mutation, delta-F508. Excluding one member of a sibling pair, 29 of 55 subjects had two copies of delta-F508 (homozygotes), 23 had one copy of delta-F508 with the other CF mutation not identified (complex heterozyg...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.2.506

    authors: Burke W,Aitken ML,Chen SH,Scott CR

    更新日期:1992-08-01 00:00:00

  • Improvement in pulmonary function in mitral stenosis after percutaneous transvenous mitral commissurotomy.

    abstract::Before and after percutaneous transvenous mitral commissurotomy (PTMC), pulmonary function studies were performed in 25 patients with mitral stenosis, in order to determine the effects of pulmonary hemodynamics on pulmonary function in patients with mitral stenosis. After PTMC, dramatic improvements in pulmonary hemod...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.98.2.290

    authors: Yoshioka T,Nakanishi N,Okubo S,Kunieda T,Ishikura F,Nagata S

    更新日期:1990-08-01 00:00:00

  • The utility of sonographic features during endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with lung cancer: a standard endobronchial ultrasound image classification system.

    abstract:BACKGROUND:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure with a high yield for lymph node staging of lung cancer. The aim of this study was to assess the utility of sonographic features of lymph nodes during EBUS-TBNA for the prediction of metastasis in p...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.09-2006

    authors: Fujiwara T,Yasufuku K,Nakajima T,Chiyo M,Yoshida S,Suzuki M,Shibuya K,Hiroshima K,Nakatani Y,Yoshino I

    更新日期:2010-09-01 00:00:00