Clonidine treatment for agitation in children after sevoflurane anesthesia.

Abstract:

:Clonidine is effective in treating sevoflurane-induced postanesthesia agitation in children. We conducted a study on 169 children to quantify the risk reduction of clonidine agitation in patients admitted to our day-surgery pediatric clinic. Children were randomly allocated to receive clonidine 2 mug/kg or placebo before general anesthesia with sevoflurane that was also supplemented with a regional or central block. An observer blinded to the anesthetic technique assessed recovery variables and the presence of agitation. Pain and discomfort scores were significantly decreased in the clonidine group; the incidence of agitation was reduced by 57% (P = 0.029) and the incidence of severe agitation by 67% (P = 0.064). Relative risks for developing agitation and severe agitation were 0.43 (95% confidence interval, 0.24-0.78) and 0.32 (0.09-1.17), respectively. Clonidine produces a substantial reduction in the risk of postsevoflurane agitation in children.

journal_name

Anesth Analg

journal_title

Anesthesia and analgesia

authors

Tesoro S,Mezzetti D,Marchesini L,Peduto VA

doi

10.1213/01.ANE.0000184204.81877.53

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1619-22

issue

6

eissn

0003-2999

issn

1526-7598

pii

101/6/1619

journal_volume

101

pub_type

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