Assessing recovery in middle cerebral artery stroke using functional MRI.

Abstract:

PRIMARY OBJECTIVE:To understand the temporal evolution of brain reorganization during recovery from stroke. RESEARCH DESIGN:A patient who suffered left middle cerebral artery stroke 9 months earlier was studied on three occasions, approximately 1 month apart. METHODS AND PROCEDURES:Brain activation was studied using functional Magnetic Resonance Imaging (fMRI). During each session, the patient performed a finger-to-thumb opposition task, which involved one bimanual and two unimanual conditions. Each condition consisted of overt movement of fingers and imagery of the same task. RESULTS:With recovery, greater recruitment was observed of the affected primary motor cortex (M1) and a decrease in activation of the unaffected M1 and supplementary motor area. In addition, the widespread activation of brain areas seen during the initial session changed to a more focused pattern of activation as the patient recovered. Imagery tasks resulted in similar brain activity as overt execution pointing to imagery as a potential tool for rehabilitation.

journal_name

Brain Inj

journal_title

Brain injury

authors

Nair DG,Fuchs A,Burkart S,Steinberg FL,Kelso JA

doi

10.1080/02699050500149858

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1165-76

issue

13

eissn

0269-9052

issn

1362-301X

pii

G43LQ37122170R08

journal_volume

19

pub_type

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