The shape of things to come: an emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton.

abstract：:Dysfunctional regulation of signaling pathways downstream of the insulin receptor plays a pivotal role in the pathogenesis of insulin resistance and type 2 diabetes. In this study we report both in vitro and in vivo experimental evidence for a role of Cullin-RING E3 ubiquitin ligase 7 (CRL7) in the regulation of insul...

journal_title：Cellular signalling

authors： Scheufele F,Wolf B,Kruse M,Hartmann T,Lempart J,Mühlich S,Pfeiffer AFH,Field LJ,Charron MJ,Pan ZQ,Engelhardt S,Sarikas A

更新日期：2014-02-01 00:00:00

abstract：:JNK signaling functions to induce defense mechanisms that protect organisms against a variety of different situations. The sestrin 2 gene, a p53-regulated member of the sestrins family, which lead to AMPK-dependent inhibition of TOR signaling, emerges as a novel player in autophagy induction. However, the relationship...

journal_title：Cellular signalling

authors： Zhang XY,Wu XQ,Deng R,Sun T,Feng GK,Zhu XF

更新日期：2013-01-01 00:00:00

abstract：:The interactions between kidney and thyroid functions have been known for many years, but how the thyroid affects the kidney function is largely unknown. Here we analyzed the role of T3 on the tubular epithelial-to-mesenchymal transition (EMT), which is recognized to play pivotal roles in the process of renal fibrosis...

journal_title：Cellular signalling

authors： Lu X,Chen Z,Liang H,Li Z,Zou X,Luo H,Guo W,Xu L

更新日期：2013-10-01 00:00:00

abstract：:Macrophages are projected as one of the key players responsible for the progression of cancer. Classically activated (M1) macrophages are pro-inflammatory and have a central role in host defense, while alternatively activated (M2) macrophages are associated with immunosuppression. Macrophages residing at the site of n...

journal_title：Cellular signalling

authors： Ghosh S,Mukherjee S,Choudhury S,Gupta P,Adhikary A,Baral R,Chattopadhyay S

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are key regulators of many cellular pathways. However, the picture for components or regulators involved in the process of miRNA biogenesis and function remains to be further elucidated. Early growth response gene 1 (Egr1) has long been considered as tumor suppressor and transcriptional fa...

journal_title：Cellular signalling

authors： Wei J,Ouyang Y,Li X,Zhu B,Yang J,Cui Y,Chen X,Lin F,Long M,Yang A,Dong K,Zhang H

更新日期：2015-06-01 00:00:00

abstract：:Nuclear receptors (NRs) orchestrate the transcription of specific gene networks in response to binding of their cognate ligand. They also act as mediators in a variety of signalling pathways through integrating diverse phosphorylation events. NR phosphorylation concerns all three major domains, the N-terminal activati...

journal_title：Cellular signalling

authors： Rochette-Egly C

更新日期：2003-04-01 00:00:00

abstract：:Therapeutic benefits and clinical application of paclitaxel for treating non-small cell lung cancers (NSCLCs) are extremely hampered due to the chemoresistance. A recent study found that fibronectin type III domain-containing protein 5 (FNDC5) was downregulated in NSCLCs cells and negatively correlated with the clinic...

journal_title：Cellular signalling

authors： Fan GH,Zhu TY,Huang J

更新日期：2020-08-01 00:00:00

abstract：:Single disseminated tumor cells (DTC) can be detected in the bone marrow (BM) from 20% to 60% of patients with various tumors including non-small cell lung cancer (NSCLC). Detection of DTC in the BM of NSCLC patients is associated with poor prognosis and may be responsible for metastatic relapse. However, the function...

journal_title：Cellular signalling

authors： Grabinski N,Bartkowiak K,Grupp K,Brandt B,Pantel K,Jücker M

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Some microRNAs (miRNAs) are involved in osteogenic differentiation. In recent years, increasing evidences have revealed that exosomes contain specific miRNAs. However, the effect and mechanism of miR-23a-5p-containing exosomes in osteoblast remain largely unclear. METHODS:We extracted exosomes from RANKL-in...

journal_title：Cellular signalling

authors： Yang JX,Xie P,Li YS,Wen T,Yang XC

更新日期：2020-06-01 00:00:00

abstract：:MAPK signalling is a complex process not only requiring the core components Raf, MEK and Erk, but also many proteins like the scaffold protein KSR and several kinases to specifically localize, modulate and fine-tune the outcome of the pathway in a cell context specific manner. In mammals, protein kinase CK2 was shown ...

journal_title：Cellular signalling

authors： Stark F,Pfannstiel J,Klaiber I,Raabe T

更新日期：2011-05-01 00:00:00

abstract：:Induction of apoptosis in Hep3B hepatoma cells by transforming growth factor beta 1 (TGF-beta 1) was accompanied by the activation of interleukin-1-beta-converting-enzyme-like proteases, which have recently been renamed as caspases. The caspase inhibitor ZVAD-FMK, which has a broader specificity for caspase family pro...

journal_title：Cellular signalling

authors： Hung WC,Chang HC,Chuang LY

更新日期：1998-07-01 00:00:00

abstract：:CD40 is critically involved in Fas-mediated cholangiocyte apoptosis during liver inflammation, but the underlying signalling events are poorly understood. Our recent work implicated AP-1 in CD40-induced cholangiocyte apoptosis, but suggested involvement of other signalling pathways. Because STAT3 has been implicated i...

journal_title：Cellular signalling

authors： Ahmed-Choudhury J,Williams KT,Young LS,Adams DH,Afford SC

更新日期：2006-04-01 00:00:00

abstract：:Cd(2+) exposure increases the risk of cancer in humans and animals. In this report, we have studied the effect of Cd(2+) on signal transduction and Ca(2+) mobilization in murine macrophages. At micromolar concentrations, Cd(2+) significantly increased cell division as judged by [3H]thymidine uptake and cell counts. Cd...

journal_title：Cellular signalling

authors： Misra UK,Gawdi G,Akabani G,Pizzo SV

更新日期：2002-04-01 00:00:00

abstract：:S6K1, a critical downstream substrate of mTORC1, has been implicated in regulating protein synthesis and a variety of processes that impinge upon cell growth and proliferation. While the role of the cytoplasmic p70(S6K1) isoform in the regulation of translation has been intensively studied, the targets and function of...

journal_title：Cellular signalling

authors： Jastrzebski K,Hannan KM,House CM,Hung SS,Pearson RB,Hannan RD

更新日期：2011-08-01 00:00:00

abstract：:The role of microtubules (MTs) in steroid hormone-dependent human glucocorticoid receptor (hGR) activation/translocation is controversial. It was demonstrated recently that colchicine (COL) down-regulates hGR-driven genes in primary human hepatocytes by a mechanism involving inhibition of hGR translocation to the nucl...

journal_title：Cellular signalling

authors： Dvorák Z,Modrianský M,Ulrichová J,Maurel P,Vilarem MJ,Pascussi JM

更新日期：2005-02-01 00:00:00

abstract：:In PC-Cl3 rat thyroid cell line, ATP and UTP provoked a transient increase in [Ca(2+)](i), followed by a lower sustained phase. Removal of extracellular Ca(2+) reduced the initial transient response and completely abolished the plateau phase. Thapsigargin (TG) caused a rapid rise in [Ca(2+)](i) and subsequent addition...

journal_title：Cellular signalling

authors： Marsigliante S,Elia MG,Di Jeso B,Greco S,Muscella A,Storelli C

更新日期：2002-01-01 00:00:00

abstract：:The activation of corticotrophin-releasing hormone receptor (CRHR) 1 is implicated in neuronal injury in experimental stroke. However, little is known about the relationship between CRHR1 activation and brain endothelial barrier impairment after ischemia and reperfusion (I/R). Recently we have demonstrated that the ac...

journal_title：Cellular signalling

authors： Cao C,Zhou J,Wu X,Qian Y,Hong Y,Mu J,Jin L,Zhu C,Li S

更新日期：2020-02-01 00:00:00

abstract：:The stimulatory effect of Mn2+ (1.5-fold), forskolin (1.6-fold) and low (1 microM) concentrations of GTP (1.9-fold) on the adenylyl cyclase of adipocyte membranes from obese, diabetic CBA/Ca mice was markedly enhanced compared to that seen using membranes prepared from their lean littermates. In contrast, receptor-med...

journal_title：Cellular signalling

authors： Palmer TM,Taberner PV,Houslay MD

更新日期：1992-07-01 00:00:00

abstract：:We found that CKD712, an S enantiomer of YS49, strongly inhibited inducible nitric oxide synthase (iNOS) and NO induction but showed a weak inhibitory effect on cyclooxygenase-2 (COX-2) and PGE(2) induction in LPS-stimulated RAW 264.7 cells. We, therefore, investigated the molecular mechanism(s) responsible for this b...

journal_title：Cellular signalling

authors： Tsoyi K,Kim HJ,Shin JS,Kim DH,Cho HJ,Lee SS,Ahn SK,Yun-Choi HS,Lee JH,Seo HG,Chang KC

更新日期：2008-10-01 00:00:00

abstract：:Cellular growth and glucose uptake are regulated by multiple signals generated by the insulin receptor. The mechanisms of individual modulation of these signals remain somewhat elusive. We investigated the role of CaMKII in insulin signalling in a rat skeletal muscle cell line, demonstrating that CaMKII modulates the ...

journal_title：Cellular signalling

authors： Illario M,Monaco S,Cavallo AL,Esposito I,Formisano P,D'Andrea L,Cipolletta E,Trimarco B,Fenzi G,Rossi G,Vitale M

更新日期：2009-05-01 00:00:00

abstract：:Antiviral responses can be triggered by the cytoplasmic RNA helicase RIG-I that binds to viral RNA. RIG-I-mediated signaling stimulates the transcription factors IRF3 and NF-κB and their activation mechanisms have been intensively studied. Here we examined Sendai virus (SV)-mediated activation of the transcription fac...

journal_title：Cellular signalling

authors： Johnsen IB,Bergstroem B,Stiberg KA,Thommesen L,Anthonsen MW

更新日期：2013-09-01 00:00:00

abstract：:The p75 neurotrophin receptor (p75(NTR)) plays a critical role in various neuronal and non-neuronal cell types by regulating cell survival, differentiation and proliferation. To evaluate the influence of p75(NTR) in breast cancer development, we have established and characterized breast cancer cells which stably overe...

journal_title：Cellular signalling

authors： Verbeke S,Meignan S,Lagadec C,Germain E,Hondermarck H,Adriaenssens E,Le Bourhis X

更新日期：2010-12-01 00:00:00

abstract：:The interferon regulated transcription factor IRF-1 is a tumour suppressor protein that is activated in response to viral infection and cell signalling activated by double stranded DNA lesions. IRF-1 has a short half-life (t(0.5) 20-40 min) allowing rapid changes in steady state levels by modulating its rate of degrad...

journal_title：Cellular signalling

authors： Pion E,Narayan V,Eckert M,Ball KL

更新日期：2009-10-01 00:00:00

abstract：:We investigated the effects of retinoic acid (RA) on the signalling pathways by prostaglandin E2 (PGE2) in osteoblast-like MC3T3-E1 cells. The pretreatment with RA significantly inhibited the formation of inositol phosphates induced by 10 microM PGE2 in a dose-dependent manner in the range between 0.1 nM and 0.1 micro...

journal_title：Cellular signalling

authors： Kotoyori J,Tokuda H,Oiso Y,Kozawa O

更新日期：1993-07-01 00:00:00

abstract：:CyrA is a novel cysteine-rich protein with four EGFL repeats that was isolated using the calmodulin (CaM) binding overlay technique (CaMBOT), suggesting it is a CaM-binding protein (CaMBP). The full-length 63kDa cyrA is cleaved into two major C-terminal fragments, cyrA-C45 and cyrA-C40. A putative CaM-binding domain w...

journal_title：Cellular signalling

authors： Suarez A,Huber RJ,Myre MA,O'Day DH

更新日期：2011-07-01 00:00:00

abstract：:Chemotaxis plays an important role in metastasis of cancer cells. In the current study, we investigated the role of PTEN, a tumor suppressor, in chemotaxis of human breast cancer cells. Over-expression of PTEN inhibited EGF-induced chemotaxis, probably due to an overall reduction of PIP(3) levels. Disruption of PTEN b...

journal_title：Cellular signalling

authors： Wan W,Zou H,Sun R,Liu Y,Wang J,Ma D,Zhang N

更新日期：2007-11-01 00:00:00

abstract：:The type III transmembrane adaptor protein linker for activation of T cells (LAT) is essential for membrane recruitment of signalling molecules following TCR activation. Here we show that although LAT deleted in the transmembrane domain is completely soluble, it can be tyrosine phosphorylated after anti-CD3 stimulatio...

journal_title：Cellular signalling

authors： Torgersen KM,Vaage JT,Rolstad B,Taskén K

更新日期：2001-03-01 00:00:00

abstract：:The CCN family is composed of six cysteine-rich, modular, and conserved proteins whose functions span a variety of tissues and include cell proliferation, adhesion, angiogenesis, and wound healing. Roles for the CCN proteins throughout the entire body including the skin, kidney, brain, blood vessels, hematopoietic com...

journal_title：Cellular signalling

authors： Piszczatowski RT,Lents NH

更新日期：2016-10-01 00:00:00

abstract：:Lovastatin was used to study the role of isoprenylated proteins on stimulus-induced increase of cytosolic Ca2+ in retinoic acid-differentiated U937 and HL-60 cells. Preincubation of the cells with lovastatin for 11-24 h reduced the Ca(2+)-influx induced by PAF of FMLP. The maximal decrease was 60% in U937 cells and 40...

journal_title：Cellular signalling

authors： Haag H,Grünberg B,Weber C,Vauti F,Aepfelbacher M,Siess W

更新日期：1994-09-01 00:00:00

abstract：:Epac1 is a cAMP-stimulated guanine exchange factor that activates Rap1. The protein product of the T cell leukemia 1 (TCL1) proto-oncogene binds to Akt enhancing its kinase activity. TCL1 and Epac promote cellular proliferation because of their activating effects on Akt. Employing macrophages, we have studied the mech...

journal_title：Cellular signalling

authors： Misra UK,Kaczowka SJ,Pizzo SV

更新日期：2008-01-01 00:00:00