Review article: the long-term use of proton-pump inhibitors.

abstract：BACKGROUND:Globally, the incidence rates of inflammatory bowel disease (IBD) are increasing; however, data from high-incidence areas are conflicting. Previous studies in Denmark have assessed incidence rates of Crohn's disease (CD) and ulcerative colitis (UC) using short observation periods. AIM:To investigate trends ...

journal_title：Alimentary pharmacology & therapeutics

authors： Lophaven SN,Lynge E,Burisch J

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor (TNF)-antagonists have an established role in the treatment of inflammatory bowel diseases (IBDs), however, subtherapeutic drug levels and the formation of anti-drug antibodies (ADAs) may decrease their efficacy. AIM:The evidence supporting the use of therapeutic drug monitoring (TDM)...

journal_title：Alimentary pharmacology & therapeutics

authors： Khanna R,Sattin BD,Afif W,Benchimol EI,Bernard EJ,Bitton A,Bressler B,Fedorak RN,Ghosh S,Greenberg GR,Marshall JK,Panaccione R,Seidman EG,Silverberg MS,Steinhart AH,Sy R,Van Assche G,Walters TD,Sandborn WJ,Feagan BG

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Anti-TNFα agents have revolutionised management of chronic inflammatory diseases. Paradoxically, these agents might provoke development of de novo autoimmune diseases. AIM:To examine whether there is an increased risk of developing Crohn's disease (CD) and ulcerative colitis (UC) while under treatment with ...

journal_title：Alimentary pharmacology & therapeutics

authors： Korzenik J,Larsen MD,Nielsen J,Kjeldsen J,Nørgård BM

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Some patients requiring acid suppression may be unable to take oral medications. AIM:To compare the gastric acid inhibition effects of lansoprazole 30 mg administered either intravenous or orally in erosive oesophagitis patients. METHODS:The study included 87 Helicobacter pylori-negative patients with eros...

journal_title：Alimentary pharmacology & therapeutics

authors： Kovacs TO,Lee CQ,Chiu YL,Pilmer BL,Metz DC

更新日期：2004-10-15 00:00:00

abstract：BACKGROUND:Different authors have postulated both toxic and protective effects for nitric oxide (NO) in the pathophysiology of active inflammation. AIM:To examine the role of NO, especially that produced by the inducible form of nitric oxide synthase (iNOS), by investigating the effects of NOS inhibitors and NO donors...

journal_title：Alimentary pharmacology & therapeutics

authors： Yoshida Y,Iwai A,Itoh K,Tanaka M,Kato S,Hokari R,Miyahara T,Koyama H,Miura S,Kobayashi M

更新日期：2000-04-01 00:00:00

abstract：:The decision regarding prophylactic treatment after surgery in Crohn's disease (CD) requires a good estimation of the risk of recurrence. It is also important to consider the consequences of recurrence for the patient, and the risks and benefits of treatment, bearing in mind that it will be given over a long period. S...

journal_title：Alimentary pharmacology & therapeutics

authors： Lémann M

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:There are few published data concerning the economic impact of antibiotic prophylaxis prior to endoscopic retrograde cholangiopancreatography in the setting of biliary obstruction. AIM:To perform decision analysis to determine the costs of prophylaxis in patients undergoing endoscopic retrograde cholangiopa...

journal_title：Alimentary pharmacology & therapeutics

authors： Thompson BF,Arguedas MR,Wilcox CM

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Although lactulose and polyethylene glycol are osmotic laxatives widely used in the treatment of chronic constipation, no study has been conducted to compare their actions on the colonic bacterial ecosystem, which has an important influence on host health. AIM:To assess the effects of lactulose and polyethy...

journal_title：Alimentary pharmacology & therapeutics

authors： Bouhnik Y,Neut C,Raskine L,Michel C,Riottot M,Andrieux C,Guillemot F,Dyard F,Flourié B

更新日期：2004-04-15 00:00:00

abstract：BACKGROUND:The seroclearance of hepatitis B surface antigen (HBsAg) in patients with chronic hepatitis B (CHB) is considered to be associated with favourable clinical outcomes. AIMS:This meta-analysis was performed to establish the proportion of HBsAg loss rates among CHB patients who received combination treatment ba...

journal_title：Alimentary pharmacology & therapeutics

authors： Qiu K,Liu B,Li SY,Li H,Chen ZW,Luo AR,Peng ML,Ren H,Hu P

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Surveillance colonoscopy is recommended for inflammatory bowel disease (IBD) patients with longstanding extensive colitis (LEC). AIMS:To assess modalities and results of colonoscopic surveillance in a subset of CESAME cohort patients at high risk of colorectal cancer (CRC) and followed in university French ...

journal_title：Alimentary pharmacology & therapeutics

authors： Vienne A,Simon T,Cosnes J,Baudry C,Bouhnik Y,Soulé JC,Chaussade S,Marteau P,Jian R,Delchier JC,Coffin B,Admane H,Carrat F,Drouet E,Beaugerie L

更新日期：2011-07-01 00:00:00

abstract：:The efforts of clinical researchers, lay organizations and pharmaceutical companies have increased the public profile of irritable bowel syndrome and made it a respectable diagnosis. Diagnostic symptom criteria encourage a firm clinical diagnosis, which is the foundation of a logical management strategy. This begins w...

journal_title：Alimentary pharmacology & therapeutics

authors： Thompson WG

更新日期：2002-08-01 00:00:00

abstract：:The effect of mefenamic acid on bowel transit time was investigated. Seven healthy adult male subjects of age 39 +/- 2.4 years (mean +/- S.E.M.) received placebo or mefenamic acid (500 mg t.d.s) orally in randomized order for five days, with a 7-day washout between studies. On the third morning after starting the drug...

journal_title：Alimentary pharmacology & therapeutics

authors： Rashid MU,Bateman DN

更新日期：1990-08-01 00:00:00

abstract：:Gastroesophagel reflux disease (GERD) is a common condition encountered in clinical practice. Over the years there has been a continuous interaction between the understanding of the disease, the diagnostic tools and treatments of GERD. The use of proton pump inhibitor (PPI) trials by primary care physicians as diagnos...

journal_title：Alimentary pharmacology & therapeutics

authors： Tutuian R,Castell DO

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The epidemiology and pathophysiology of non-erosive gastro-oesophageal reflux disease differs from erosive gastro-oesophageal reflux disease. There is a possibility that non-erosive gastro-oesophageal reflux disease treatment requires a different regimen/approach but it is not yet acknowledged. AIM:To inves...

journal_title：Alimentary pharmacology & therapeutics

authors： Wada T,Sasaki M,Kataoka H,Tanida S,Itoh K,Ogasawara N,Oshima T,Togawa S,Kubota E,Yamada T,Mori Y,Fujita F,Ohara H,Nakao H,Sobue S,Joh T,Itoh M

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Dexlansoprazole MR is a Dual Delayed Release formulation of dexlansoprazole, an enantiomer of lansoprazole, designed to extend the duration of acid suppression. AIM:To assess the 12-month safety of dexlansoprazole MR in patients with symptomatic gastro-oesophageal reflux disease (GERD). METHODS:In this ran...

journal_title：Alimentary pharmacology & therapeutics

authors： Dabholkar AH,Han C,Paris MM,Perez MC,Atkinson SN,Peura DA

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Application of electrical stimulation to the gut, primarily the stomach, has rapidly advanced in the last two decades, from mostly animal studies to the clinical arena. Most studies focused on the use of electrical stimulation for gastroparesis, the only approved indication for such intervention. AIM:To rev...

journal_title：Alimentary pharmacology & therapeutics

authors： Soffer E,Abell T,Lin Z,Lorincz A,McCallum R,Parkman H,Policker S,Ordog T

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:The role of 5-hydroxytryptamine in the control of gastric fundus tone in humans is still unknown. Selective 5-hydroxytryptamine re-uptake inhibitors act both centrally and peripherally to enhance the availability of physiologically released 5-hydroxytryptamine. AIM:To study the influence of a selective 5-hy...

journal_title：Alimentary pharmacology & therapeutics

authors： Tack J,Broekaert D,Coulie B,Fischler B,Janssens J

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:Treatment with interferon-alpha has been shown to be effective in one-third of hepatitis B e antigen-positive chronic hepatitis B patients, but is clinically associated with relevant adverse events. AIM:To investigate the safety of pegylated interferon alpha-2b in 300 hepatitis B e antigen-positive patients...

journal_title：Alimentary pharmacology & therapeutics

authors： van Zonneveld M,Flink HJ,Verhey E,Senturk H,Zeuzem S,Akarca US,Cakaloglu Y,Simon C,So TM,Gerken G,de Man RA,Hansen BE,Schalm SW,Janssen HL,HBV 99-01 Study Group.

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Radiotherapy is an established treatment modality for prostate cancer; however, up to a third of patients develops a radiation-induced proctopathy. AIM:To assess the effect of topical beclomethasone dipropionate (BDP) in the prevention of radiation-induced proctopathy in patients undergoing radiotherapy for...

journal_title：Alimentary pharmacology & therapeutics

authors： Fuccio L,Guido A,Laterza L,Eusebi LH,Busutti L,Bunkheila F,Barbieri E,Bazzoli F

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Delta virus (HDV)-related chronic hepatitis is difficult to treat. AIMS:To evaluate the efficacy of lamivudine 100 mg daily on serum HDV-RNA, hepatitis D virus antibodies and alanine aminotransferase levels, liver histology, and on hepatitis B surface antigen seroconversion. METHODS:Thirty-one hepatitis B ...

journal_title：Alimentary pharmacology & therapeutics

authors： Niro GA,Ciancio A,Tillman HL,Lagget M,Olivero A,Perri F,Fontana R,Little N,Campbell F,Smedile A,Manns MP,Andriulli A,Rizzetto M

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Retrospective accounts suggest that therapeutic doses of paracetamol can produce severe hepatic injury in patients with putative high-risk conditions, including alcoholism and infectious hepatitis. Metabolism of paracetamol to its hepatotoxic metabolite is enhanced in patients who abuse alcohol, who also hav...

journal_title：Alimentary pharmacology & therapeutics

authors： Dart RC,Green JL,Kuffner EK,Heard K,Sproule B,Brands B

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:The long-term time trends of multiple gastrointestinal diseases are characterised by a striking rise and fall. These temporal changes provide important clues about disease aetiology. AIM:To highlight the importance of Helicobacter pylori infection in shaping the temporal trends of many common gastrointestin...

journal_title：Alimentary pharmacology & therapeutics

authors： Sonnenberg A

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Carcinoma of the gall-bladder is the fifth commonest gastrointestinal tract cancer and is endemic in several countries. An association of chronic typhoid carriage and carcinoma of the gall-bladder has been reported. AIM:To clarify whether chronic Salmonella typhi carrier state is associated with carcinoma o...

journal_title：Alimentary pharmacology & therapeutics

authors： Nagaraja V,Eslick GD

更新日期：2014-04-01 00:00:00

abstract：:Colorectal cancer is a common cancer and common cause of death. The mortality rate from colorectal cancer can be reduced by identification and removal of cancer precursors, adenomas, or by detection of cancer at an earlier stage. Pilot screening programmes have demonstrated decreased colorectal cancer mortality; as a ...

journal_title：Alimentary pharmacology & therapeutics

authors： Nicholson FB,Barro JL,Atkin W,Lilford R,Patnick J,Williams CB,Pignone M,Steele R,Kamm MA

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors (PPIs) are the preferred agents for the prevention of aspirin-associated upper gastrointestinal bleeding (UGIB). Data are limited to determine whether PPIs are being used to reduce UGIB risk. AIM:To evaluate the implementation of PPI treatment to reduce the GI risk in two cardiology c...

journal_title：Alimentary pharmacology & therapeutics

authors： Casado-Arroyo R,Scheiman JM,Polo-Tomas M,Saini SD,Del Rio A,Guastello E,Lanas A

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Incidence and mortality of gastric cancer (GC) are high in Mongolia despite Helicobacter pylori in the Mongolian population being less virulent. AIM:To evaluate gastric bacterial microbiota profiles in patients with GC and its precursor histological conditions. METHODS:We conducted a case-control study amo...

journal_title：Alimentary pharmacology & therapeutics

authors： Gantuya B,El Serag HB,Matsumoto T,Ajami NJ,Uchida T,Oyuntsetseg K,Bolor D,Yamaoka Y

更新日期：2020-04-01 00:00:00

abstract：:There is some evidence from clinical, experimental and multiprobe ambulatory pH studies that gastro-oesophageal reflux is more common in patients with laryngeal symptoms and could potentially play a role in the causation of these symptoms. The proportion of unselected patients with laryngeal symptoms who have gastro-o...

journal_title：Alimentary pharmacology & therapeutics

authors： Fraser AG

更新日期：1994-06-01 00:00:00

abstract：AIM:To define the characteristics of patients consulting with active dyspeptic symptoms in urban general practice, and to consider the implications of applying the British Society of Gastroenterology Dyspepsia management guidelines. DESIGN:Prospective observational study over a period of 12 months. SETTING:Two multip...

journal_title：Alimentary pharmacology & therapeutics

authors： Bodger K,Eastwood PG,Manning SI,Daly MJ,Heatley RV

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Prebiotics have been shown to reduce abdominal symptoms in patients with functional gut disorders, despite that they are fermented by colonic bacteria and may induce gas-related symptoms. AIM:To investigate changes in the metabolic activity of gut microbiota induced by a recognised prebiotic. METHODS:Healt...

journal_title：Alimentary pharmacology & therapeutics

authors： Mego M,Manichanh C,Accarino A,Campos D,Pozuelo M,Varela E,Vulevic J,Tzortzis G,Gibson G,Guarner F,Azpiroz F

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is characterised by intense mucosal recruitment of activated leukocytes. Chemokines determine inflammatory leukocyte recruitment and retention. AIM:To compare expression of the entire chemokine family within colonic mucosa from IBD patients and uninflamed controls. METHODS:...

journal_title：Alimentary pharmacology & therapeutics

authors： Puleston J,Cooper M,Murch S,Bid K,Makh S,Ashwood P,Bingham AH,Green H,Moss P,Dhillon A,Morris R,Strobel S,Gelinas R,Pounder RE,Platt A

更新日期：2005-01-15 00:00:00