Abstract：
:The molecular mechanisms involved in the aging of collagen and consequent increase in mechanical strength and stiffness occur in a series of enzymic and non-enzymic intermolecular cross-links. The enzymic mechanism involves divalent aldimine intermolecular cross-links derived from the reaction of aldehydes which then mature to trivalent cross-links and further stabilize the collagen fiber and is now well known. Recent studies have demonstrated that the rate of turnover and level of telopeptide lysyl hydroxylation modifies the nature of the cross-link and hence the mechanical strength of the fiber. The slow turnover of mature collagen subsequently allows accumulation of the products of the adventitious non-enzymic reaction of glucose with the lysines in the triple helix to form glucosyl lysine and its Amadori product, that is, the Maillard reaction. These products are subsequently oxidized to a complex series of advanced glycation end-products, some of which are intermolecular cross-links between the triple helices rendering the fiber too stiff for optimal functioning of the collagen fibers, and consequently of the particular tissue involved. The glycation reactions following maturation are true aging processes, and attempts at their specific inhibition involve competitive inhibition of the Maillard reaction and chemical cleavage of the glycation cross-links. It is clear that the nature of the age-related cross-links and hence tissue strength depends on the rate of turnover of the collagen. An examination of the particular effect of strenuous exercise on the rate of turnover of collagen and hence cross-linking in different tissues could lead to a better understanding of optimal sports training regimes.
journal_name
Scand J Med Sci Sportsjournal_title
Scandinavian journal of medicine & science in sportsauthors
Avery NC,Bailey AJdoi
10.1111/j.1600-0838.2005.00464.xsubject
Has Abstractpub_date
2005-08-01 00:00:00pages
231-40issue
4eissn
0905-7188issn
1600-0838pii
SMS464journal_volume
15pub_type
杂志文章abstract：:This study investigated the relationship between delayed-onset muscle soreness and other indicators of muscle damage following eccentric exercise. Male students (n = 110) performed 12 (12ECC), 24 (24ECC), or 60 maximal eccentric actions of the elbow flexors (60ECC). Maximal isometric force, relaxed and flexed elbow jo...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1034/j.1600-0838.2002.10178.x
更新日期：2002-12-01 00:00:00
abstract：:In military operations, declined physical capacity can endanger the life of soldiers. During special support and reconnaissance (SSR) missions, Special Forces soldiers sustain 1-2 weeks full-body horizontal immobilization, which impairs muscle strength and performance. Adequate muscle mass and strength are necessary i...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12170
更新日期：2015-04-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13842
更新日期：2021-02-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13918
更新日期：2021-01-17 00:00:00
abstract：:Internet websites offering androgenic anabolic steroids (AAS) were identified and available products were examined. Keywords for the website search were: "anabolic steroids," "anabolic steroids buy," "anabolic steroid purchase." The first 10 websites offering AAS in the first 10 pages of results were considered. At le...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2010.01263.x
更新日期：2011-12-01 00:00:00
abstract：:Our aim was to investigate the presence of mechanical hypersensitivity and active trigger points (TrPs) in the neck-shoulder muscles in elite swimmers with/without unilateral shoulder pain. Seventeen elite swimmers with shoulder pain; 18 swimmers without shoulder pain; and 15 elite athletes matched controls were recru...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-0838.2011.01331.x
更新日期：2013-02-01 00:00:00
abstract：:Examinations of stress in coaches have mainly been qualitative and focused on chronic stressors. This exploratory study examined stress responses in coaches during competition, including psychological and physiological indices. Using reversal theory, we examined metamotivational state profiles during competition. Ten ...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12075
更新日期：2013-10-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13503
更新日期：2019-11-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-0838.2011.01338.x
更新日期：2011-08-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13273
更新日期：2018-12-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12262
更新日期：2015-10-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章,随机对照试验
doi：10.1111/sms.12852
更新日期：2017-12-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2010.01118.x
更新日期：2011-12-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1034/j.1600-0838.2001.011002115.x
更新日期：2001-04-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13629
更新日期：2020-05-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12554
更新日期：2016-10-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12394
更新日期：2015-12-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-0838.2010.01154.x
更新日期：2012-02-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 临床试验,杂志文章
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更新日期：2003-10-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2006.00597.x
更新日期：2007-10-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13247
更新日期：2018-11-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章,随机对照试验
doi：10.1111/sms.12364
更新日期：2015-06-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章,评审
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更新日期：2018-03-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12078
更新日期：2013-10-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12224
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Acute Achilles tendon rupture (ATR) is a frequently disabling injury, which exhibits unclear variability in long-term functional and patient-reported outcomes. Biomarkers from early healing, which have been shown to be prognostic of long-term outcome would facilitate the development of improved treatment met...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.13469
更新日期：2019-10-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.1997.tb00125.x
更新日期：1997-04-01 00:00:00
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journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/sms.12805
更新日期：2017-12-01 00:00:00
abstract：:The aim of this study was to examine the stability of objectively measured physical activity in Swedish children and to study variables that predicted physical activity and body mass index standard deviation score (BMI SDS) at follow-up. A total of 97 children provided valid repeated measurements of physical activity ...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章
doi：10.1111/j.1600-0838.2007.00756.x
更新日期：2009-02-01 00:00:00
abstract：:This study aimed to determine simultaneously the effects of plyometric training on the passive stiffness of the ankle joint musculo-articular complex, the gastrocnemii muscle-tendon complex (MTC) and the Achilles tendon in order to assess possible local adaptations of elastic properties. Seventeen subjects were divide...
journal_title：Scandinavian journal of medicine & science in sports
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-0838.2008.00853.x
更新日期：2009-12-01 00:00:00
