Metabolic characteristics in individuals with impaired glucose homeostasis.

Abstract:

:We sought to clarify whether impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or both (IFG/IGT) represent the most severe impairment in insulin resistance (IR) and insulin secretion. Among the 159 Chinese subjects, 21 were diagnosed as having IFG, 103 as having IGT and 35 as having both. IR and beta-cell function were assessed using homeostatic model assessment (HOMA) and an insulin-suppression test (IST). No differences were evident between the groups in blood pressure, body mass index, plasma insulin fasting levels and lipid profiles. However, plasma 2-h insulin levels were higher in the IGT and IFG/IGT groups. Beta-cell functions were not different between these groups. But, the result of glucose tolerance was different, in which the IFG/IGT and IFG groups displayed higher insulin sensitivity than IGT via HOMA instead of no difference via IST in the three patient groups.

journal_name

Int J Clin Pract

authors

Hsieh CH,Kuo SW,Hung YJ,Shen DC,Ho CT,Lian WC,Lee CH,Fan SC,Pei D

doi

10.1111/j.1742-1241.2005.00494.x

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

639-44

issue

6

eissn

1368-5031

issn

1742-1241

pii

IJCP494

journal_volume

59

pub_type

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