[Retinal nerve fiber layer alteration in chronic users of chloroquine].

Abstract:

PURPOSES:To evaluate the retina nerve fiber layer by laser polarimetry in patients in chronic use of chloroquine. METHODS:Forty-four eyes of twenty-two patients were studied. These were in use of chloroquine due to rheumatic diseases during at least one year. As a control group, twenty patients without use of chloroquine with similar characteristics (age, gender and race) were included. Patients who had a family history of ocular hypertension or glaucoma were not included in this group. Both eyes were submitted to analysis of the retina nerve fiber layer with a GDx Nerve Fiber Analyzer. RESULTS:In 28 eyes (63.6%) of chronic chloroquine users, alterations in more than two parameters by GDx were found. There was alteration in the Deviation from the normal graph with a loss of nerve fibers in 11 eyes (25%). When these results were compared with the control group, there was a significant statistical difference between the following parameters: Superior Ratio, Inferior Ratio, Superior Nasal, Elipse Modulation, The Number, Superior Average and Superior Integral. There was also a significant statistical association between the time of chloroquine use and loss of nerve fiber layer. CONCLUSIONS:From the results the following conclusion can be drawn: the chronic use of chloroquine was associated with alteration of the nerve fiber layer. Thus these results may contribute to early diagnosis of nerve fiber layer loss in chloroquine retinopathy.

journal_name

Arq Bras Oftalmol

authors

Antunes Dde A,Cavalcanti HD,Leal D,Santana HV,Santos RA,Santos LP

doi

10.1590/s0004-27492005000200008

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

195-7

issue

2

eissn

0004-2749

issn

1678-2925

pii

S0004-27492005000200008

journal_volume

68

pub_type

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