Two-pore domain potassium channels: new sites of local anesthetic action and toxicity.

abstract：BACKGROUND AND OBJECTIVES:Bupivacaine is a racemic mixture of S(-)- and R(+)-enantiomers. Both isomers have similar potency as local anesthetics, but the S(-)-enantiomer produces less central nervous system and cardiovascular toxicity. Local anesthetic-induced convulsion is likely to be associated with not only sodium ...

journal_title：Regional anesthesia and pain medicine

authors： Ueta K,Sugimoto M,Suzuki T,Uchida I,Mashimo T

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Several studies have evaluated the impact of preoperative depression on outcomes following total joint arthroplasty (TJA), however few have studied new-onset depression or anxiety after TJA. We aimed to identify the incidence of and risk factors for new-onset depression/anxiety after TJA, specifically focusi...

journal_title：Regional anesthesia and pain medicine

authors： Wilson L,Bekeris J,Fiasconaro M,Liu J,Poeran J,Kim DH,Gonzalez Della Valle A,Memtsoudis SG

更新日期：2019-09-16 00:00:00

abstract：BACKGROUND:This prospective, randomized, observer-blinded study compared ultrasound guidance and the conventional landmark-based technique for superficial cervical plexus blockade. METHODS:Forty patients were randomly allocated to receive a block of the superficial cervical plexus using ultrasound guidance (n = 20) or...

journal_title：Regional anesthesia and pain medicine

authors： Tran DQ,Dugani S,Finlayson RJ

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Stellate ganglion block (SGB) is one treatment option for human trigeminal nerve injury. The aim of this study was to evaluate the effectiveness of cervical sympathetic ganglia blocks (SB) by comparing the recovery of severed nerves in 2 rat models, treated or not treated by SB. METHODS:The i...

journal_title：Regional anesthesia and pain medicine

authors： Hanamatsu N,Yamashiro M,Sumitomo M,Furuya H

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:Sacroiliac joint injections are frequently performed procedures in the management of acute and chronic low-back pain, including patients with various immunocompromised states. Infectious complications following these procedures along with other spinal injections are rarely reported, but the true incidence is ...

journal_title：Regional anesthesia and pain medicine

authors： Nagpal G,Flaherty JP,Benzon HT

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:To describe a late neurologic complication of intrathecal pump implantation and show the methods used for the diagnosis and successful treatment of transverse myelitis in this setting. CASE REPORT:A 32-year-old man with a chronic abdominal pain syndrome presented with right lower-extremity numbness 2 months ...

journal_title：Regional anesthesia and pain medicine

authors： Ubogu EE,Lindenberg JR,Werz MA

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The transarterial axillary block and the ultrasound-guided infraclavicular block are both effective methods of anesthetizing the upper extremity. This study compares these methods with respect to subjective postoperative dysesthesias, block adequacy, patient comfort, and patient satisfaction. ...

journal_title：Regional anesthesia and pain medicine

authors： Tedore TR,YaDeau JT,Maalouf DB,Weiland AJ,Tong-Ngork S,Wukovits B,Paroli L,Urban MK,Zayas VM,Wu A,Gordon MA

更新日期：2009-07-01 00:00:00

abstract：:This article qualitatively assesses and summarizes randomized, controlled studies regarding benefits of ultrasound (US) for brachial plexus block and also examines those studies that have compared different brachial plexus block techniques using US.Studies were identified by a search of PUBMED and EMBASE databases usi...

journal_title：Regional anesthesia and pain medicine

authors： McCartney CJ,Lin L,Shastri U

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:There is increasing interest in local infiltration analgesia (LIA) to reduce postoperative pain with knee surgery. Despite widespread use of LIA, wide variations in drug combinations, infiltration techniques, and the concomitant use of systemic analgesics have made it difficult to determine th...

journal_title：Regional anesthesia and pain medicine

authors： Buvanendran A,Kroin JS,Della Valle CJ,Moric M,Tuman KJ

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The ideal spread of local anesthetic for effective, rapid, and safe sciatic nerve block is debated. We hypothesized that subparaneural ultrasound-guided injection results in faster onset and has a better success rate than extraneural circumferential spread. METHODS:Patients undergoing elective tibial, foot,...

journal_title：Regional anesthesia and pain medicine

authors： Choquet O,Noble GB,Abbal B,Morau D,Bringuier S,Capdevila X

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Accurate needle control during ultrasound (US)-guided nerve blocks may be an elusive goal for the anesthesiologist. Despite modifications to increase echogenicity, needle visibility still requires precise alignment within the transducer beam. In this study, we evaluated a magnetically guided u...

journal_title：Regional anesthesia and pain medicine

authors： Swenson JD,Klingler KR,Pace NL,Davis JJ,Loose EC

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The effect of intravenous dexamethasone on the duration of axillary plexus block performed using ropivacaine is not described. The aim of this study is to assess the effect of intravenous dexamethasone on the duration of axillary plexus block analgesia after distal upper arm surgery. METHODS:...

journal_title：Regional anesthesia and pain medicine

authors： Clement JC,Besch G,Puyraveau M,Grelet T,Ferreira D,Vettoretti L,Pili-Floury S,Samain E,Berthier F

更新日期：2019-03-01 00:00:00

abstract：:The COVID-19 outbreak is on the world. While many countries have imposed general lockdown, emergency services are continuing. Healthcare professionals have been infected with the virulent severe acute respiratory syndrome coronavirus-2 (SARS), which spreads by close contact and aerosols. The anesthesiologist is partic...

journal_title：Regional anesthesia and pain medicine

authors： Ashokka B,Chakraborty A,Subramanian BJ,Karmakar MK,Chan V

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Amputations of the lower extremity remain a common procedure in a high-risk population. Perioperative morbidity and mortality reach as high as 14.1% in below-knee amputations. We aimed to determine whether regional, or neuraxial, anesthesia, when compared with general anesthesia (GA), would be...

journal_title：Regional anesthesia and pain medicine

authors： Malik O,Brovman EY,Urman RD

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Third occipital nerve block (TONB) is commonly used in the diagnosis and treatment of upper neck pain and cervicogenic headaches. Although fluoroscopy is the current imaging standard for TONB, ultrasound (US) guidance offers a promising, radiation-free alternative. In this randomized, observer-blinded trial,...

journal_title：Regional anesthesia and pain medicine

authors： Finlayson RJ,Etheridge JP,Vieira L,Gupta G,Tran DQ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND/IMPORTANCE:Ultrasound (US)-guided cervical selective nerve root injections (CSNRI) have been proposed as an alternative to fluoroscopic (FL) -guided injections. When choosing US guidance, the proceduralist should be aware of potential issues confirming vertebral level, be clear regarding terminology, and up ...

journal_title：Regional anesthesia and pain medicine

authors： Ehsanian R,Schneider BJ,Kennedy DJ,Koshkin E

更新日期：2021-01-13 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Ultrasound-guided infiltration of the interspace between the popliteal artery and capsule of the knee (iPACK) block, a new regional analgesic technique, is believed to relieve posterior knee pain, after total knee arthroplasty, by targeting the articular branches innervating posterior aspect o...

journal_title：Regional anesthesia and pain medicine

authors： Tran J,Giron Arango L,Peng P,Sinha SK,Agur A,Chan V

更新日期：2019-05-06 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Anesthesia and analgesia with paravertebral block are reportedly variable. Existence of an endothoracic fascia has been proposed as one of the possible mechanisms leading to variability. We undertook an electron-microscopy imaging study to investigate the endothoracic fascia in the thoracic pa...

journal_title：Regional anesthesia and pain medicine

authors： Stopar Pintaric T,Veranic P,Hadzic A,Karmakar M,Cvetko E

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Lipid infusion reverses systemic local anesthetic toxicity. The acceptable upper limit for lipid administration is unknown and has direct bearing on clinical management. We hypothesize that high volumes of lipid could have undesirable effects and sought to identify the dose required to kill 50% of the animal...

journal_title：Regional anesthesia and pain medicine

authors： Hiller DB,Di Gregorio G,Kelly K,Ripper R,Edelman L,Boumendjel R,Drasner K,Weinberg GL

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:Local anesthetic-induced cardiotoxicity remains a complication of regional anesthesia, with the potential to result in cardiac arrest refractory to resuscitation. Successful resuscitation using Intralipid (Baxter Pharmaceuticals by Fresenius Kabi, Uppsala, Sweden), has been reported in 2 patients with bupivac...

journal_title：Regional anesthesia and pain medicine

authors： McCutchen T,Gerancher JC

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Despite ultrasound (US) guidance, sciatic nerve block (SNB) remains among the least performed peripheral blocks. By targeting the tissue plane between the gluteus maximus and quadratus femoris muscles, the US-guided subgluteal space technique may facilitate the performance of US-guided SNB. We...

journal_title：Regional anesthesia and pain medicine

authors： Abdallah FW,Chan VW,Koshkin A,Abbas S,Brull R

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:This study examined whether perioperative multimodal analgesia (MMA) improves the effectiveness of intravenous nutrition (IVN) as a means of preventing protein wasting following major upper abdominal surgery (UAS). The MMA regimen utilized combined epidural opioid/local anesthetic and the syst...

journal_title：Regional anesthesia and pain medicine

authors： Barratt SM,Smith RC,Kee AJ,Mather LE,Cousins MJ

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The posterior approach to performing a continuous brachial plexus block at the level of the nerve roots has been described using traditional superficial landmarks. We describe an ultrasound-guided approach for the placement of a continuous interscalene brachial plexus catheter at the level of ...

journal_title：Regional anesthesia and pain medicine

authors： Antonakakis JG,Sites BD,Shiffrin J

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:This prospective randomized trial compared ultrasound-guided single-injection (SI) and triple-injection (TI) subparaneural popliteal sciatic nerve block. We hypothesized that multiple injections are not required when local anesthetic (LA) is deposited under the paraneurium because the latter e...

journal_title：Regional anesthesia and pain medicine

authors： Tiyaprasertkul W,Bernucci F,González AP,Leurcharusmee P,Yazer MS,Techasuk W,Arnuntasupakul V,de la Garza DC,Finlayson RJ,Tran DQ

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Stimulation of the radial nerve at the axilla may cause either a proximal movement (forearm extension) or distal movements (supination, wrist or finger extension). In the most recent studies on axillary block, only a distal twitch was accepted as valid. However, this approach was based only on...

journal_title：Regional anesthesia and pain medicine

authors： Sia S,Lepri A,Magherini M,Doni L,Di Marco P,Gritti G

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:The underlying mechanisms of neuropathic pain remain unclear. This work aimed to investigate the role of Sirtuin3 (SIRT3), an nicotinamide adenosine dinucleotide+-dependent histone deacetylase, in the development of neuropathic pain induced by type 2 diabetes mellitus (T2DM) and to explore the associated mec...

journal_title：Regional anesthesia and pain medicine

authors： Zhou C,Zhang Y,Jiao X,Wang G,Wang R,Wu Y

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Perioperative systemic lidocaine provides postoperative analgesia, decreases opioid consumption, and facilitates rehabilitation in abdominal surgery. We hypothesized that systemic lidocaine has analgesic effects in women undergoing day-case laparoscopic sterilization. METHODS:Eighty women wer...

journal_title：Regional anesthesia and pain medicine

authors： Dewinter GB,Teunkens A,Vermeulen K,Al Tmimi L,Van de Velde M,Rex S

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:This study reports our early experience with continuous cervical paravertebral block (CCPVB) using a stimulating catheter for the management of acute pain after shoulder surgery. METHODS:This prospective observational study presents 256 CCPVB for pain relief after 14 different shoulder operat...

journal_title：Regional anesthesia and pain medicine

authors： Boezaart AP,De Beer JF,Nell ML

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:This prospective, randomized, and multicentered study was undertaken to evaluate the success rate of coracoid infraclavicular nerve block performed with a nerve stimulator when either 1 or 3 motor responses were sought. METHODS:Eighty patients who presented for elbow, forearm, or wrist surger...

journal_title：Regional anesthesia and pain medicine

authors： Gaertner E,Estebe JP,Zamfir A,Cuby C,Macaire P

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Although complications of the epidural technique are known to affect the fetus adversely, there are no data indicating that regional analgesia directly causes harmful effects to the fetus. Our purpose was to determine the effect of epidural labor analgesia on the Doppler velocimetric indices of the uterine an...

journal_title：Regional anesthesia and pain medicine

authors： Chen LK,Yang YM,Yang YH,Lee CN,Chen SS,Sun WZ

更新日期：2011-05-01 00:00:00