Abstract：
:Risk management of food-animal antibiotics has reached a crucial juncture for public health officials worldwide. While withdrawals of animal antibiotics previously used to control animal bacterial illnesses are being encouraged in many countries, the human health impacts of such withdrawals are only starting to be understood. Increases in animal and human bacterial illness rates and antibiotic resistance levels in humans in Europe despite bans on animal antibiotics there have raised questions about how animal antibiotic use affects human health. This paper presents a quantitative human health risk and benefits assessment for virginiamycin (VM), a streptogramin antibiotic recommended for withdrawal from use in food animals in several countries. It applies a new quantitative Rapid Risk Rating Technique (RRRT) that estimates and multiplies data-driven exposure, dose-response, and consequence factors, as suggested by WHO (2003) to estimate human health impacts from withdrawing virginiamycin. Increased human health risks from more pathogens reaching consumers if VM use is terminated (6660 estimated excess campylobacteriosis cases per year in the base case) are predicted to far outweigh benefits from reduced streptogramin-resistant vancomycin-resistant Enterococcus faecium (VREF) infections in human patients (0.27 estimated excess cases per year in the base case). While lack of information about impacts of VM withdrawal on average human illnesses-per-serving of food animal meat precludes a deterministic conclusion, it appears very probable that such a withdrawal would cause many times more human illnesses than it would prevent. This qualitative conclusion appears to be robust to several scientific and modeling uncertainties.
journal_name
Environ Intjournal_title
Environment internationalauthors
Cox LA Jrdoi
10.1016/j.envint.2004.10.012subject
Has Abstractpub_date
2005-05-01 00:00:00pages
549-63issue
4eissn
0160-4120issn
1873-6750pii
S0160-4120(04)00187-4journal_volume
31pub_type
杂志文章abstract：:Soil can be a storage place and source of pollutants for interfacial environments. This study looked at a site contaminated with wood preservatives as a source of mutagens, defined routes and extent of the dispersion of these contaminants by particle remobilization and atmospheric deposition, considering an evaluation...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2012.01.008
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:There is increasing policy interest in the potential for vegetation in urban areas to mitigate harmful effects of air pollution on respiratory health. We aimed to quantify relationships between tree and green space density and asthma-related hospitalisations, and explore how these varied with exposure to bac...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2017.08.009
更新日期：2017-12-01 00:00:00
abstract：:Few population studies have measured urinary levels of pesticides in individuals with vegan, vegetarian, or organic diets. The objectives of this study were to evaluate whether a vegan/vegetarian diet was associated with increased exposure to organophosphate and carbamate pesticides, and to evaluate the impact of orga...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2016.08.027
更新日期：2016-11-01 00:00:00
abstract：:Tamoxifen (TAM) is a first generation-SERM administered for hormone receptor-positive (HER+) breast cancer in both pre- and post-menopausal patients and may undergo metabolic activation in organisms that share similar receptors and thus face comparable mechanisms of response. The present study aimed to assess whether ...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2019.05.014
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:The evidence for an association between particulate air pollution and type 2 diabetes mellitus (T2DM) in developing countries was very scarce. OBJECTIVE:To investigate the associations of long-term exposure to fine particulate matter (PM2.5) with T2DM prevalence and with fasting glucose and glycosylated hem...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2016.03.028
更新日期：2016-07-01 00:00:00
abstract：:Domoic acid (DA) is a neurotoxin that is naturally produced by phytoplankton and accumulates in seafood during harmful algal blooms. As the prevalence of DA increases in the marine environment, there is a critical need to identify seafood consumers at risk of DA poisoning. DA exposure was estimated in recreational raz...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2017.01.006
更新日期：2017-04-01 00:00:00
abstract：:Data regarding which microenvironments drive exposure to air pollution in low and middle income countries are scarce. Our objective was to identify sources of time-resolved personal PM2.5 exposure in peri-urban India using wearable camera-derived microenvironmental information. We conducted a panel study with up to 6 ...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2018.05.021
更新日期：2018-08-01 00:00:00
abstract：:Deoxynivalenol (DON), one of the most widespread mycotoxins in Europe, and cadmium (Cd), a widespread environmental pollutant, are common food contaminants. They exert adverse effects on different organs including kidney, liver, and intestine. The intestine is a common target of DON and Cd when they are ingested. Most...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2019.105082
更新日期：2019-11-01 00:00:00
abstract：:Although atmospheric microplastics have been found to be ubiquitous even on untraversed mountains and have potential impacts on human health, little information concerning their sampling methodology and transport is currently available. Until a realistic quantification of suspended atmospheric microplastics (SAMPs) is...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2019.105127
更新日期：2019-11-01 00:00:00
abstract：:Exposure to dioxins and polychlorinated biphenyls (PCBs) during pregnancy and breastfeeding may result in adverse health effects in children. Prenatal exposure is determined by the concentrations of dioxins and PCBs in maternal blood, which reflect the body burden obtained by long term dietary exposure. The aims of th...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2013.07.001
更新日期：2013-09-01 00:00:00
abstract：:There is a wide concern that emerging organic pollutants (EOPs) in surface water could adversely affect human health and wildlife. However, the geographic distribution, exposure pattern and ecological risk of emerging organic pollutants are poorly understood at a global scale. This paper provides a comprehensive surve...
journal_title：Environment international
pub_type： 杂志文章,评审
doi：10.1016/j.envint.2019.104994
更新日期：2019-10-01 00:00:00
abstract：:In recent years there has been an increased interest from the European Union (EU) in the development of large Human Bio-monitoring (HBM) studies across Europe, especially biomonitoring toxic metals. In Spain, most studies using hair as a biomarker have been conducted to determine occupational or industrial exposures, ...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2014.03.010
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Exposure to noise poses auditory and non-auditory effects on health. The gastrointestinal tract is considered as the site of adverse reactions to noise-induced stress; little attention has been paid to a potential link between noise and peptic ulcers. OBJECTIVES:The aim of this study was to investigate whet...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2018.10.035
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Blood lead levels (BLLs) were measured in the adult Inuit population of Nunavut, Northern Canada, during the Inuit Health Survey (IHS) in 2007-2008. Approximately 10% of the adult participants had BLL over the Health Canada's guidance of 100μg/L. OBJECTIVES:1) To repeat the measurement of BLL among the IHS ...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2014.06.004
更新日期：2014-10-01 00:00:00
abstract：:Elevated blood pressure in childhood is an important risk factor for hypertension in adulthood. Environmental exposures have been associated with elevated blood pressure over the life course and exposure to mercury (Hg) has been linked to cardiovascular effects in adults. As subclinical vascular changes begin early in...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2020.106201
更新日期：2021-01-01 00:00:00
abstract：:Dietary exposure to persistent organochlorine pesticides (OCPs) was assessed for Chinese populations, using the total diet study (TDS) approach in 2007. Multistage random cluster sampling method was used in this study. 108 composite samples, representative of foods "as consumed" by the Chinese were analyzed for residu...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2011.05.018
更新日期：2012-07-01 00:00:00
abstract：:A 2-year field experiment was conducted in an Ochric Aquic Cambosols on a 1-ha field with rotation of winter wheat-summer corn located in Fengqiu County in North China Plain from 1 October 1998 to 30 September 2000 to quantify water balance and evaluate soil water loss by deep drainage and nitrate loss by leaching out...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2005.05.038
更新日期：2005-08-01 00:00:00
abstract：:Brominated flame retardants (BFRs) are ubiquitous industrial chemicals, and many of them are produced in large volumes. Due to this fact, several BFRs are found in quantifiable levels in wildlife, as well as in humans. However, we are still lacking information on the effects of BFR in wildlife and, especially, in man....
journal_title：Environment international
pub_type： 杂志文章,评审
doi：10.1016/S0160-4120(03)00107-7
更新日期：2003-09-01 00:00:00
abstract：:Long-term air quality data with high temporal and spatial resolutions are needed to understand some important processes affecting the air quality and corresponding environmental and health effects. The annual and diurnal variations of each criteria pollutant including PM2.5 and PM10 (particulate matter with aerodynami...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2015.11.003
更新日期：2016-01-01 00:00:00
abstract：:The occurrence of nineteen mixed halogenated (bromo-chloro) dibenzo-p-dioxins, dibenzofurans (PXDD/Fs) and biphenyls (PXBs) in a range of foods (n>100) was investigated. The analytical methodology used dual activated carbon column fractionation with high resolution mass spectrometric measurement (13,500-15,000 res). O...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2014.07.007
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Thyroid antibodies (TAs) are the most common cause of hypothyroidism during gestation. Although previous studies found that prenatal exposure to perfluoroalkyl substances (PFASs) disrupts thyroid hormones (THs) in humans, their effects on TAs during the perinatal period have not been investigated. OBJECTIVE...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2019.105139
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Major food contaminants such as polychlorinated biphenyls (PCBs) are proposed to play a role in the etiology of cardiovascular disease (CVD), but to date the impact of PCBs on cardiovascular health need to be explored. METHODS AND RESULTS:We assessed the association between validated food frequency question...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2015.11.020
更新日期：2016-03-01 00:00:00
abstract：:Respirometric tests on a soil contaminated by crude oil were performed. Continuous measurements of oxygen and carbon dioxide concentrations and temperature in the soil atmosphere resulted in a large volume of data. Time series and system identification theories were used to analyze data as a biological signal, allowin...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2004.09.013
更新日期：2005-02-01 00:00:00
abstract：:Transfer and toxic effects of two cadmium (Cd) forms, inorganic (CdCl2 dosed rat food) or organic (contaminated snail-based rat food) were studied in Wistar rat. Cd concentrations in rat food were 0 and 2.5 microg Cd g(-1) for both inorganic and organic forms and a high concentration of 100 microg Cd g(-1) was also te...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2007.09.003
更新日期：2008-04-01 00:00:00
abstract：:Hormone steroids are a group of endocrine disruptors, which are excreted by humans and animals. In this paper, we briefly review the current knowledge on the fate of these steroids in the environment. Natural estrogenic steroids estrone (E1), 17beta-estradiol (E2) and estriol (E3) all have a solubility of approximatel...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/s0160-4120(02)00075-2
更新日期：2002-12-01 00:00:00
abstract：:From 1975 to 2004, a municipal solid waste incinerator (MSWI) was operating in Montcada (Barcelona, Catalonia, Spain). Because of the potential health risks derived from emission of pollutants by the facility, especially polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), a long-term monitoring progra...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2005.09.002
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVES:We applied three statistical approaches for evaluating associations between prenatal urinary concentrations of a mixture of phthalate metabolites and birth weight. METHODS:We included 300 women who provided 732 urine samples during pregnancy and delivered a singleton infant. We measured urinary concentratio...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2018.02.005
更新日期：2018-04-01 00:00:00
abstract：:Seaweed has a long-associated history of use as a supplemented livestock feed, providing nutrients and vitamins essential to maintaining animal health. Some species of seaweed, particularly the fucoids, are well-known accumulators of the metalloid arsenic (As). Arsenic toxicity to humans is well established even at lo...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2018.05.032
更新日期：2018-09-01 00:00:00
abstract：:The EU Water Framework Directive (WFD) is novel because it integrates water quality, water resources, physical habitat and, to some extent, flooding for all surface and groundwaters and takes forward river basin management. However, the WFD does not explicitly mention risks posed by climate change to the achievement o...
journal_title：Environment international
pub_type： 杂志文章,评审
doi：10.1016/j.envint.2006.06.017
更新日期：2006-12-01 00:00:00
abstract：:Dioxin-like compounds (DLCs) are monitored in the U.S. population using data collected with the National Health and Nutrition Examination Survey (NHANES). Until recently, participants' serum samples have been analyzed individually, and summary statistics defining reference ranges by age, gender, and race/ethnicity hav...
journal_title：Environment international
pub_type： 杂志文章
doi：10.1016/j.envint.2017.05.003
更新日期：2017-08-01 00:00:00
